Continuous spike-waves during slow–wave sleep: Experience during 20 years

Fernández, Laura Escobar; Góngora, Alejandra Coccolo; López, María Vázquez; Arrondo, Ana Paloma Polo; Herrero, M.C. Miranda; Valderrama, Estíbaliz Barredo; Castro, P. Castro de

doi:10.1016/j.anpede.2018.12.004

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…After the initial description by Patry et al, 1 electrical status epilepticus in sleep (ESES) was studied in many patients with idiopathic and symptomatic epilepsies. [2][3][4][5][6][7][8][9][10] Although the prognosis in the idiopathic cases, concerning the seizures and electroencephalogram (EEG), is favorable, a significant proportion of the children remain with cognitive impairment and/or behavioral problems. 5,[10][11][12] Taking into account the negative effect on cognition, the efforts of the clinicians are focused on determining the predictors for ESES manifestation 5,8,[13][14][15][16][17] and the factors that have an influence upon the degree of cognitive impact.…”

Section: Introductionmentioning

confidence: 99%

Electrical Status Epilepticus during Sleep: Risk Factors, Clinical Course, and Treatment Approaches

Aleksandrova

Asenova

Dimova

et al. 2023

Journal of Child Science

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Background The efforts of clinicians are focused on determining the predictors for electrical status epilepticus in sleep (ESES) manifestation, due to the negative effect of ESES on cognition. Treatment approaches remain a leading problem because of therapeutic resistance. Objective We looked for potential risk factors for ESES manifestation and summarize the clinical course and therapeutic approaches in patients with idiopathic and symptomatic ESES. Patients and Methods We retrospectively reviewed the medical data of 51 children with idiopathic ESES and 20 children with symptomatic ESES. Results We observed an earlier age of seizure onset (p = 0.0002) and a higher percentage of cases with multiple seizures (p < 0.00001) and with postictal paralysis (p < 0.00001) in idiopathic ESES compared with childhood epilepsy with centrotemporal spikes. In the idiopathic ESES, the treatment consisted of corticosteroids in patients with permanent ESES remission and transient remission, levetiracetam (LEV) children with permanent ESES remission and transient, clonazepam (CZP) children with permanent ESES remission and transient, ethosuximide (ESM), and sulthiame. The patients with symptomatic ESES had more unfavorable evolution, as 19 children had persistent or relapsing ESES course. Conclusion We consider the earlier age of seizure onset (below 5 years) and the presence of multiple seizures and postictal paresis as risk factors for ESES manifestation. ESES is characterized by a significant therapeutic resistance, especially in the group of symptomatic cases. Good results are observed with LEV, ESM, CZP, and steroids.

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