Anesthesia for lung transplantation is both a demanding and rewarding experience. Success requires teamwork, experience, knowledge of cardiorespiratory pathophysiology and its anesthetic implications, appropriate use of noninvasive and invasive monitoring, and the ability to respond quickly and effectively to lifethreatening perioperative events. Specific issues include management of a patient with end-stage lung and heart disease, lung isolation and one-lung ventilation, perioperative respiratory failure, pulmonary hypertension, and acute right ventricular failure. Recent advances include greater understanding of dynamic hyperinflation ("gas-trapping") during mechanical ventilation, perioperative use of inhaled nitric oxide and treatment of acute right ventricular failure. Successful anesthetic management leads to greater hemodynamic stability, improvement in gas exchange and a reduction in need for cardiopulmonary bypass, all of which should lead to improved patient outcome.Copyright@ 1998 by IIV. B. Saunders Company.Anesthesia for lung transplantation is one of the most complicated and demanding procedures that anesthesiologists are confronted with in their practice. Issues that arise include management of a patient with end-stage lung and heart disease, lung isolation and one-lung ventilation (OLV), perioperative respiratory failure, pulmonary hypertension and right ventricular (RV) failure, pathophysiology of cardiopulmonary bypass (CPB), coagulopathy and multiple blood product transfusion, maintenance of other vital organ function (especially brain and kidneys), and postoperative pain management.1&dquo;21 Critical incidents during the procedure are common and often life-threateningB-11 ,14,19,20; they demand rapid assessment and intervention. This can be compromised by anesthesiologist fatigue because most lung transplantation procedures take 6 to 10 hours and usually occur at night, often after a busy cardiothoracic operating scheduse.1,2,4 Successful management demands both knowledge and experience, and this is best optimized by concentrating clinical exposure to lung transplantation among a small number of dedicated anesthesiologists at any one institution. Although this increases individual work load, it does enhance expertise and consistency of practice. Work schedules the day after transplantation can be reorganized, and this is most efficiently achieved with a cohesive cardiothoracic anesthetic team. As with other types of specialized surgery, 22 outcome after lung transplantation may be affected by caseload, with larger units having more favorable results.5 Accumulating experience within an institution is also associated with improved outcome'5 ; at the author's institution, a 50% reduction from 20% to 10% in early (<90 days) postoperative mortality rate over the first 7 years of the program (G. Snell, personal communication, May 20, 1997) has been observed.Ideally, clinical practice should be evidencebased, guided by clinical trials showing superiority of one treatment over another.23,24 However, i...