Continuous subcutaneous glucose monitoring in children with type 1 diabetes mellitus: a single-blind, randomized, controlled trial

Abstract

CGMS use may improve metabolic control in children with T1DM without increasing the risk for hypoglycemia.

Continuous Glucose Monitoring System in children with type 1 diabetes mellitus: a systematic review and meta-analysis

“…We also found significant differences in the frequency of insulin changes: >11 times during 1 month (experimental group only) [17], every 3 weeks [18], every 6 weeks [16] and every 2 months [19]. Follow-up periods extended up to 3 months in three trials [15][16][17] and up to 6 months in the other two trials [18,19].…”

“…Table 1 summarises characteristics of the included trials. Five RCTs involving 131 participants met our predefined inclusion criteria [15][16][17][18][19]; the remaining 20 studies were excluded [7,[11][12][13][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. Table 2 summarises the characteristics of excluded trials, including reasons for exclusion.…”

“…All included trials were small, one-centre studies; two of them were performed in Europe [15,16], two in the USA [17,19] and one in Australia [18]. Three of the included trials [17][18][19] had parallel-group design and two others [15,16] were crossover.…”

“…Three of the included trials [17][18][19] had parallel-group design and two others [15,16] were crossover. There was considerable clinical heterogeneity among the trials with regard to the children's age, diabetes duration, frequency of CGMS use and insulin adjustments.…”

“…Depending on the trial, patients had to wear CGMS: every 5 days [17], every 2 weeks [16], every 3 weeks [18], every 2 months [19] or once during a 3 month period [15]. We also found significant differences in the frequency of insulin changes: >11 times during 1 month (experimental group only) [17], every 3 weeks [18], every 6 weeks [16] and every 2 months [19]. Follow-up periods extended up to 3 months in three trials [15][16][17] and up to 6 months in the other two trials [18,19].…”