Continuous subcutaneous glucose monitoring in diabetic patients: A multicenter evaluation

Maran, Alberto; Crepaldi, C.; Tiengo, Antonio; Grassi, Giorgio; Vitali, Ettore; Pagano, Gianfranco; Bistoni, S.; Calabrese, Giuseppe; Santeusanio, Fausto; Leonetti, Frida; Ribaudo, Mária Cristina; Mario, U. Di; Annuzzi, Giovanni; Genovese, Stefano; Riccardi, Gabriele; Previti, M.; Cucinotta, Domenico; Giorgino, Francesco; Perrini, Sebastio; Giorgino, R; Poscia, Alessandro; Varalli, M

doi:10.1016/s0168-8227(00)81135-3

Cited by 14 publications

(19 citation statements)

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“…The CGM system that we used measures interstitial fluid glucose as a surrogate measure of blood glucose but proved highly reliable, returning glucose values that tallied closely with blood glucose measurements. 29,30 The strength of our study lies in its novelty because it is the first to have been conducted using the additional glucose variability parameters now available to assess the impact of glucose excursions on fetal growth.…”

Section: Discussionmentioning

confidence: 99%

“…The analytical performance of the device is known, as reported in two major studies by Maran et al 29 and Kovatchev et al 30 For each monitoring session, the GDS microdialysis probe, comprising 2 cm of hollow fiber (regenerated cellulose with an internal diameter of 0.17 mm and a molecular mass cutoff of 18,000 Da) was inserted subcutaneously in the patient's abdominal region using an 18-gauge Teflon Ò (Dupont, Wilmington, DE) catheter as a guide. After implantation, the probe was connected to the GDS portable device, which contains a flow cell comprising a platinum electrode (0.4 mm in diameter) covered with three membranes (cellulose acetate, an enzyme membrane, and a polycarbonate membrane) housed in a Teflon tube.…”

Section: Study Protocolmentioning

confidence: 99%

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Glucose Variability in Diabetic Pregnancy

Dalfrà

Sartore²,

Cianni³

et al. 2011

Diabetes Technology & Therapeutics

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Section: Discussionmentioning

confidence: 99%

Section: Study Protocolmentioning

confidence: 99%

Glucose Variability in Diabetic Pregnancy

Dalfrà

Sartore²,

Cianni³

et al. 2011

Diabetes Technology & Therapeutics

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“…A microdialysis system that allows semi-continuous glucose monitoring under hospital conditions is available (CMA Microdialysis, Solna, Sweden). Roche Diagnostics (Mannheim, Germany) has recently developed a new microdialysis system for daily life conditions that registers continuously over 72 h. The Menarini company (Florence, Italy) had also developed a microdialysis system which recently has been certified for 24-h use [29].…”

Section: Microdialysismentioning

confidence: 99%

Sensors for glucose monitoring: technical and clinical aspects

Koschinsky

Heinemann

2001

Diabetes Metab. Res. Rev.

270

149

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The aim of this article is to critically discuss the technical and clinical aspects of glucose sensors and to briefly review current technical developments. This includes sensors for spot glucose measurements as well as those used for continuous glucose monitoring. Continuous glucose monitoring in particular should supply the diabetic patient with all the information required to optimize insulin therapy and metabolic control. Such systems should also allow hypo- and hyperglycemic episodes to be avoided. During the last 30 years numerous attempts have been made to develop glucose sensors, and new major breakthroughs have been announced repeatedly. However, up until now no glucose sensor has been available that can be used by diabetic patients in daily life conditions. Also one type of glucose sensor, a glucose electrode, recently received approval by the Food and Drug Administration (USA) and is commercially available. Other glucose sensors employing the transdermal, microdialysis or open tissue microperfusion technique are currently under clinical development and may also become available in the near future. The types of glucose sensors referred to so far are not truly non-invasive, but only minimally invasive. They measure glucose concentration in the interstitial fluid of the skin or the subcutis. Non-invasive optical glucose sensors are designed to monitor glucose changes in the skin by directing light through it. They measure the characteristics of the reflected light that are changed as the result of an interaction with glucose. However, none of the attempts with optical glucose sensors have resulted thus far in the development of a sensor that allows monitoring of glucose with sufficient accuracy and precision within the clinically relevant glucose range in daily life conditions. Nevertheless, more minimal-invasive glucose sensors systems will become available for practical use in the near future, whereas it is still uncertain if this can be said for any non-invasive glucose sensor.

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“…These features allowed the GlucoDay to enter into a multicenter European clinical trial to evaluate the accuracy in monitoring glucose levels in type 1 and type 2 diabetic patients. A total of 70 diabetic patients (43 type 1 and 27 type 2 diabetic patients, 38 women and 32 men) from seven different centers participated in this study [80].…”

Section: Glucodaymentioning

confidence: 99%

Ex Vivo Continuous Glucose Monitoring With Microdialysis Technique: The Example of GlucoDay

2008

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The use of a glucose biosensor in conjunction with a microdialysis probe used to sample the interstitial fluid of the patient has been demonstrated to be extremely useful and advantageous for obtaining a continuous glucose monitoring instrument capable of detecting glycemic level in real time for a long period. The first example of this kind of instrument which was cleared for commercialization is the GlucoDay made by Menarini. The approach used by the GlucoDay presents several advantages if compared with other instruments and its features and future prospective are thoroughly discussed.

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Continuous subcutaneous glucose monitoring in diabetic patients: A multicenter evaluation

Cited by 14 publications

References 0 publications

Glucose Variability in Diabetic Pregnancy

Glucose Variability in Diabetic Pregnancy

Sensors for glucose monitoring: technical and clinical aspects

Ex Vivo Continuous Glucose Monitoring With Microdialysis Technique: The Example of GlucoDay

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