In this paper, we focus on a batch manufacturing system with multiple industrial robots. In this system, material-handling robots (MHRs) and material-processing robots (MPRs) are operating. Since various operations are conducted at certain places, one of them might include a localized bottleneck. A localized bottleneck is a constraint that dominates the maximum amount of production in a system, that is, the productivity. In addition, the bottleneck induces congestion; as a result, the productivity declines. For these issues, there are two primary challenges: bottleneck prevention and restraint. To solve them, suitable operational techniques with respect to the MHRs and MPRs are needed in order for them to operate appropriately while relating to each other. In this paper, a constructive approach toward multi-robot coordination problems is taken. In this approach, we propose applicable operational techniques for the robots. Through simulation experiments, we examine the effectiveness of the proposed techniques and their combinations and, finally, show an integrated operational technique. Each of the operational techniques solves a localized bottleneck and the congestion, and the integrated technique successfully improves the productivity and results in the most efficient system.Note to Practitioners-The primary motivation for this study was the pursuit of answers to the problems associated with production operations for a pipeless batch plant system in chemical process industries. These solutions will also apply to other manufacturing systems for high-mix low-volume production with a number of machines or robots. In many previous studies, scientists addressed the optimization problem of production scheduling; in this study, however, we focus on a simulation study and aim to develop an applicable integration technology for the coordination of operating robots in the interest of the automation of a highly flexible production activity. In practical batch manufacturing systems, as an entire operational strategy, it is necessary to equalize the flow of products, i.e., bottlenecks, throughout the system. Furthermore, once a localized bottleneck appears, its harmful effect on the system has to be restrained. Therefore, we suggest efficient operational techniques to tackle these challenging issues. Through various simulation experiments, we show that some good combinatorial techniques enable to improve productivity. The results of this paper are feasible and sufficient for flexible batch manufacturing systems, but the application is limited to a system in which the safety of production operations and processes is guaranteed. In future research, we will address design problems regarding safety and reliability in a plant system.