Continuous-Use Ethinylestradiol/Levonorgestrel 20μg/90μg as an Oral Contraceptive

Davtyan, Camelia

doi:10.2165/00003495-200767160-00011

Cited by 2 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, 30 days after the commencement of fertility control agent treatments, no significant difference was observed in the estradiol, testosterone, or corticosterone hormone levels. However, we observed a significant decrease in follicle-stimulating hormone levels in the EP-1-treated group; this phenomenon can be attributed to mixed levonorgestrel and quinestrol interfering with the in vivo regulation of the hypothalamic-pituitary-adrenal axis (Bednarek 2007;Likis 2002). However, the specific interference mechanism of EP-1 and why levonorgestrel and quinestrol do not inhibit follicle-stimulating hormone levels when used alone still require further research.…”

Section: Effects Of Fertility Control Agents On Liver Tissuementioning

confidence: 72%

Peer Review #1 of "The reproductive inhibitory effects of levonorgestrel, quinestrol, and EP-1 in Brandt’s vole (Lasiopodomys brandtii) (v0.1)"

2020

View full text Add to dashboard Cite

Background. Rodent pests can inflict devastating impacts on agriculture and the environment, leading to significant economic damage associated with their high species diversity, reproductive rates, and adaptability. Fertility control methods can indirectly control rodent pest populations as well as limit ecological consequences and environmental concerns caused by lethal chemical poisons. Brandt's voles, which are common rodent pests that are found in the grasslands of middle-eastern Inner Mongolia, eastern regions of Mongolia, and some regions of southern Russia, were assessed in the present study. Methods. We evaluated the effects of levonorgestrel, quinestrol, and a 1:1 mixture of the two (EP-1) on reproductive behavior as well as changes in the reproductive system, reproductive hormone levels, and toxicity in Brandt's voles. Results. Our results revealed that all three fertility control agents can cause sterility at a dosage of 2 mg/kg. However, quinestrol caused a greater degree of toxicity, as determined by visible liver damage and reduced expression of the detoxifying molecule CYP1A2. Of the remaining two fertility control agents, EP-1 was superior to levonorgestrel in inhibiting the secretion of follicle-stimulating hormone and causing sterility. We believe that these findings will help promote the use of these fertility control agents and, in turn, reduce the use of chemical poisons and limit their detrimental ecological and environmental impacts.

show abstract

Section: Effects Of Fertility Control Agents On Liver Tissuementioning

confidence: 72%

Peer Review #1 of "The reproductive inhibitory effects of levonorgestrel, quinestrol, and EP-1 in Brandt’s vole (Lasiopodomys brandtii) (v0.1)"

2020

View full text Add to dashboard Cite

show abstract

“…Unscheduled bleeding is a common adverse effect with extended-cycle COC regimens 65 66. However, this has been found to decrease with each successive cycle of extended pill use 42.…”

Section: Resultsmentioning

confidence: 99%

Evolution of extended use of the combined oral contraceptive pill

Panicker

Mann

Shawe

et al. 2014

J Fam Plann Reprod Health Care

View full text Add to dashboard Cite

Background Extended use of the combined oral contraceptive pill (COC), defined as taking active pills for at least 28 days, has been used in order to avoid bleeding at important times and to treat gynaecological conditions such as endometriosis. We examined the main issues involved in extended use of the COC and how it has evolved from being one of medicine's best-kept secrets to becoming more widely accepted by women and the medical community. Study design Literature review, using Medline, Embase, Pubmed, CINHAL Plus, the Cochrane Database of Systematic Reviews and the Ovid database for all relevant clinical trials, systematic reviews, meta-analyses, literature reviews, scientific papers and individual opinions between 1950 and October 2013. Results Accumulating evidence supports various forms of extended pill use as suitable alternatives to the standard (21/7) regimen. In terms of user preference, much hinges on whether women wish to reduce the frequency or duration of scheduled bleeding on the combined pill. Available data on the safety of extended pill regimens do not give cause for concern, but longer term data should be collected. Conclusions Information for women considering extended COC regimens should keep pace with research findings to ensure that women and clinicians are better informed about the choices available.

show abstract

Continuous-Use Ethinylestradiol/Levonorgestrel 20μg/90μg as an Oral Contraceptive

Cited by 2 publications

References 1 publication

Peer Review #1 of "The reproductive inhibitory effects of levonorgestrel, quinestrol, and EP-1 in Brandt’s vole (Lasiopodomys brandtii) (v0.1)"

Peer Review #1 of "The reproductive inhibitory effects of levonorgestrel, quinestrol, and EP-1 in Brandt’s vole (Lasiopodomys brandtii) (v0.1)"

Evolution of extended use of the combined oral contraceptive pill

Contact Info

Product

Resources

About