CONTOUR Australia: Condition of Submental Fullness and Treatment Outcomes with Belkyra Registry

Abstract

Background: Submental fat (SMF) contributes to an aged or overweight appearance that may negatively impact an individual’s psychological well-being. Deoxycholic acid (ATX-101) is an injectable formulation of deoxycholic acid approved to treat SMF. The Condition of Submental Fullness and Treatment Outcomes Registry (CONTOUR) Australia study was designed to understand treatment patterns and outcomes with ATX-101 in Australia. Methods: CONTOUR Australia was a phase 4, prospective, observational, multicenter registry that enrolled adults considering treatment for SMF reduction. Results: The registry enrolled 86 patients from six sites. Significant changes from baseline through the end of treatment indicated improvement in mild to moderate fullness associated with SMF on the Clinician-Reported SMF Rating Scale and the Patient-Reported SMF Rating Scale, improvement in SMF-associated psychological impact after treatment on the Patient-Reported SMF Impact Scale, no overall worsening in skin laxity based on Submental Skin Laxity Grade, and increased patient satisfaction with the face/chin on the Subject Self-Rating Scale after receiving treatment. Adverse events were all mild and mostly related to the injection site (ie, bruising and swelling). Conclusion: CONTOUR Australia observed clinically meaningful and significant outcomes and further supports ATX-101 as a well-tolerated and effective treatment for SMF reduction.

New Protocol: EndoliftX Laser and Hyaluronic Ac+ Calcium Hydroxiapaptite as an Effective Approach for Facial Rejuvenation- Case Series of 7 Patients

“…However, they may necessitate multiple sessions, and the results can take time to become noticeable. On the other hand, non-surgical energy-based methods, such as radiofrequency devices and cryolipolysis, can provide more rapid results with a single session but may entail discomfort during treatment and potentially longer recovery times due to swelling and bruising [1][2][3][4][5][6][7][8][9].…”

“…The increasing concern regarding these issues has driven interest in non-invasive and minimally invasive treatments for submental fat and tissue laxity. Patients now have various treatment options, including injectable treatments, nonsurgical energy-based methods, and surgical procedures [1][2][3][4][5][6][7][8][9][10]. One minimally invasive option is laser lipolysis.…”