We consider the evolution of two incompressible, immiscible fluids with different densities in porous media, known as the Muskat problem [21], which in two dimensions is analogous to the Hele‐Shaw cell [24]. We establish, for a class of large and monotone initial data, the global existence of weak solutions. The proof is based on a local well‐posedness result for the initial data with certain specific asymptotics at spatial infinity and a new maximum principle for the first derivative of the graph function.© 2016 Wiley Periodicals, Inc.