Spontaneous Reporting System (SRS) has been widely established to collect adverse drug events. Thus, SRS promotes the detection and analysis of ADR (adverse drug reactions), such as the FDA Adverse Event Reporting System (FAERS). The SRS data needs to be provided to researchers. Meanwhile, the SRS data is publicly available to facilitate the study of ADR detection and analysis. In general, SRS data contains private information of some individual characteristics. Before the information is published, it is necessary to anonymize private information in the SRS data to prevent disclosure of individual privacy. There are many privacy protection methods. The most classic method for protecting SRS data is called as PPMS. However, in the real world, SRS data is growing dynamically and needs to be published regularly. In this case, PPMS has some shortcomings in the memory consumption, anonymity efficiency, data update and data security. To remove these shortcomings, we propose an Efficient Q-value Zero-leakage protection Scheme in SRS regularly publishing private data, called EQZS. EQZS can deal with almost all of potential attacks. Meanwhile, EQZS removes the shortcomings of PPMS. The experimental results show that our scheme EQZS solves the problem of privacy leakage in SRS regularly publishing private data. Meanwhile, EQZS significantly outperforms PPMS on the efficiency of memory consumption, privacy anonymity and data update.