Contra-Insular Effect of Calcitonin on Glucose Metabolism

Moisa, Svetlana Stepanovna

doi:10.1007/s10517-013-2314-y

Cited by 6 publications

(9 citation statements)

References 6 publications

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“…The enhancing level of contra-insular hormones pays the especial attention. As far as we think, that CT for its effect on glucose homeostasis can regard to contra-insular hormones [2,3], so, hypercalcitoninemia, induced by stress influence [4] or in case of CT treatment, under the unfavorable conditions can lead to the development of IR. We'll consider CT participant in the development of IR in brief.…”

Section: Calcitonin and Insulin Resistancementioning

confidence: 99%

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Calcitonin Participant in the Development of Insulin Resistance

Moisa¹

2017

JBiSE

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The review contains contemporary literature data about calcitonin role in the development of insulin resistance and its potential role in the pathogenesis of carbohydrate metabolism disturbances. Analogues disturbances revealed under diabetes mellitus and under calcitonin treatment are considered. Literature data about hormone diabetogenicity are discussed. The analysis of experimental and literature data testifies that calcitonin under unfavorable conditions (age, obesity, stress) against the background of the decreasing of functional activity of insular apparatus can lead to the development of metabolic syndrome and diabetes mellitus. It is shown that calcium channel blockers inhibit calcitonin effect leads to glucose intolerance and decreases tissue insulin sensitivity. In this connection a question about direct influence on calcium mechanisms of endocrine system as possible method of drug therapy is discussed.

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Section: Calcitonin and Insulin Resistancementioning

confidence: 99%

“…The sensitivity of ß-cells to glucose is most important quantitative parameter of their functional capacity [5]. CT inhibits insulin secretion against the background of glucose load per os and provokes glucose intolerance [3], i.e. promotes to the development of IR on the pre-receptor level.…”

Section: Calcitonin and Insulin Resistancementioning

confidence: 99%

Calcitonin Participant in the Development of Insulin Resistance

Moisa¹

2017

JBiSE

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“…In previous investigations [1][2][3][4][5][6][7][8][9][10], we established that the effect of calcitonin on glucose level reveals hyperglycemia, glucose intolerance and insulin resistance. It was interesting to study the effect of other calcium-regulating hormone-calcitonin antagonist-parathyrin on glucose homeostasis.…”

Section: Introductionmentioning

confidence: 99%

One-Time Injection of Parathyrin Increases Glucose Tolerance

Moisa¹,

Ноздрачев²

2013

OJEMD

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One-time injection of domestic preparation of bull parathyrin-parathyreoidin (1 U/100g body weight, intramuscular) leads to a significant decrease of the blood glucose level and an increase of the serum calcium level in rats. There is a close negative correlation established between glucose and calcium level (r = −0.813, P > 0.02). The calcium laktat load (9 mg) per os induces the same changes. There is a functional negative correlation established between glucose levels and total calcium content (r = −0.997, P < 0.01). It proves that the decrease of the blood glucose level under parathyrin injection is connected with hypercalcaemia. Parathyrin causes the reduction of the dynamics of hyperglycemia under the glucose load per os (30% solution, 1 ml/100g), i.e. parathyrin increases glucose tolerance. Glucose consumption by muscle (diaphragm) and adipose (epididymal) tissues in vivo and in vitro does not alter under parathyrin and it does not affect the stimulating effect of insulin on the process. The combinative effect of parathyrin and calcium channel blockers-isoptin (5 mg/kg, intraperitoneal) or nifedipin (1 mg/kg, intraperitoneal) reveals more intensive and lasting decrease of the blood glucose level in comparison with only parathyrin effect and more reduction of the dynamics of hyperglycemia under the glucose load. Thus, parathyrin decreases the blood glucose level, increases glucose tolerance and does not effect insulin resistance.

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“…These changes result in hyperglycemia, insulin resistance, and impaired glucose tolerance. Hence, CT can be considered as a contra-insular hormone [2,5]. It can be hypothesized that CT takes part in neuroendocrine regulation of glucose metabolism, especially during hypercalcitoninemia.…”

Section: Methodsmentioning

confidence: 99%

“…However, there are a lot of facts about CT hyperglycemic, contra-insular effect and it participant in the development of insulin resistance [1][2][3][4][5][6] have studied now. More less facts are known about PTH effects on glucose metabolism [7,8].…”

Section: Introductionmentioning

confidence: 99%

Calcitonin and parathyrin are antagonists concerning to the regulation of glucose metabolism

Moisa¹

2018

Integr Food Nutr Metab

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Materials about calcium-regulating hormones (calcitonin and parathyrin) effect on carbohydrate regulation are represented. It is showed calcitonin hyperglycemic effect, its contra-insulin effect to insulin. It is ascertained the impairment of glucose metabolism under calcitonin-hyperglycemia, insulin resistance and glucose intolerance. It is established the opposite to calcitonin action of parathyrin on glucose metabolism: decreasing the glucose level and increasing glucose tolerance. It is concluded that calcitonin and parathyrin are antagonists not only concerning to the regulation of calcium metabolism, but and glucose.

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Contra-Insular Effect of Calcitonin on Glucose Metabolism

Cited by 6 publications

References 6 publications

Calcitonin Participant in the Development of Insulin Resistance

Calcitonin Participant in the Development of Insulin Resistance

One-Time Injection of Parathyrin Increases Glucose Tolerance

Calcitonin and parathyrin are antagonists concerning to the regulation of glucose metabolism

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