Contracepción hormonal oral en Dermatología

Sancho, B.; Guerra‐Tapia, A.

doi:10.1016/s0001-7310(09)71590-x

Cited by 6 publications

(1 citation statement)

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“…[2] Combined oral contraceptives contain an estrogen (such as ethinylestradiol or mestranol) and a progestin (such as desogestrel, drospirenone, levonorgestrel or chlormadinone). [21] Together they reduce the effect of androgens by reducing ovarian and adrenal androgen production and by blocking the action of androgens in the PSU. The ethinylestradiol component inhibits luteinizing hormone [22] and follicle-stimulating hormone (FSH) thus reducing serum androgen levels.…”

Section: Rationale For the Use Of Oral Contraceptives For The Treatmementioning

confidence: 99%

Ethinylestradiol/Chlormadinone Acetate

Guerra‐Tapia¹,

Pérez²

2011

American Journal of Clinical Dermatology

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Acne vulgaris, hirsutism, seborrhea and female pattern hair loss (FPHL) are common disorders of the pilosebaceous unit (PSU). In some women with hyperandrogenemia, an excess of androgens at the PSU can lead to the development of these dermatological manifestations. These manifestations can cause many psychiatric and psychological implications, such as social fears and anxiety, and can adversely affect quality of life. High androgen levels at the PSU as a possible underlying cause of acne vulgaris, hirsutism, seborrhea and FPHL supports the rationale for using combined oral contraceptives for the management of these conditions in women. The purpose of this review is to describe these dermatological manifestations of the PSU and the management of these conditions through the use of the oral contraceptive ethinylestradiol/chlormadinone acetate (EE/CMA). EE/CMA 0.03/2 mg is a combined monophasic contraceptive pill with anti-androgenic properties. It is approved in Europe for contraception and has been investigated in phase III trials for the treatment of acne. EE/CMA was better than placebo and similar to another low-dose oral contraceptive (ethinylestradiol/levonorgestrel) in improving symptoms of acne in two phase III randomized controlled trials in patients with mild to moderate papulopustular acne. In addition, in trials investigating the contraceptive efficacy of EE/CMA, limited data suggest that there were also improvements in hirsutism, FPHL and seborrhea in small subgroups of patients. EE/CMA has a good safety profile. The most commonly reported adverse events are breast tenderness/pain, headache/migraine and nausea. Evidence in the literature indicates that the use of EE/CMA for the treatment of dermatological disorders under the control of androgens may be a valid treatment option. Further investigation is warranted.

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Section: Rationale For the Use Of Oral Contraceptives For The Treatmementioning

confidence: 99%