Contraception and pregnancy in cystic fibrosis

Thorpe-Beeston, J. G.

doi:10.1258/jrsm.2009.s19002

Cited by 17 publications

(16 citation statements)

References 47 publications

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“…50 Indefinite use of systemic progestogens is unwise in patients with CF as it may aggravate pre-existing low bone mineral density. The choice between each of these options should be considered on an individual basis and in consultation with the patient, the CF team and the general practitioner or a specialist obstetrician.…”

Section: Fertility and Contraceptionmentioning

confidence: 99%

Pregnancy and cystic fibrosis: Approach to contemporary management

et al. 2014

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Over the previous 50 years survival of patients with cystic fibrosis has progressively increased. As a result of improvements in health care, increasing numbers of patients with cystic fibrosis are now considering starting families of their own. For the health care professionals who look after these patients, the assessment of the potential risks, and the process of guiding prospective parents through pregnancy and beyond can be both challenging and rewarding. To facilitate appropriate discussions about pregnancy, health care workers must have a detailed understanding of the various important issues that will ultimately need to be considered for any patient with cystic fibrosis considering parenthood. This review will address these issues. In particular, it will outline pregnancy outcomes for mothers with cystic fibrosis, issues that need to be taken into account when planning a pregnancy and the management of pregnancy for mothers with cystic fibrosis or mothers who have undergone organ transplantation as a result of cystic fibrosis.

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Section: Fertility and Contraceptionmentioning

confidence: 99%

Pregnancy and cystic fibrosis: Approach to contemporary management

et al. 2014

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“…Возросло число мужчин, до-стигших репродуктивного возраста, и возникли вопро-сы об их репродуктивном и сексуальном здоровье. Вопрос о фертильности и контрацепции у мужчин с муковисцидозом должен быть поставлен в 16-18 лет [8]. Рекомендовано обследование состояния репродук-тивной системы мальчиков с муковисцидозом с 12 лет, так как характерно раннее возникновение урогениталь-ных аномалий и их прогрессирование.…”

Section: Discussionunclassified

“…Рекомендуется проведение анализа частых мутаций гена CFTR у супруга пациента с муковисци-дозом, а в случае выявления носительства патогенных вариантов гена CFTR -проведение преимплантаци-онной и/или пренатальной диагностики [8,21].…”

Section: Discussionunclassified

“…Семявыносящие протоки имеют наи-большую чувствительность к снижению доли функци-онального белка хлорного канала, кодируемого геном CFTR, поэтому поражаются в первую очередь по срав-нению с другими органами и тканями-мишенями для данного гена [1]. Нарушение фертильности у мужчин без муковисцидоза/CBAVD, имеющих мутации гена CFTR, чаще подразумевает патозооспермию, снижен-ное количество сперматозоидов и их худшие свойства [1,[8][9][10].…”

Section: Introductionunclassified

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Andrology Examination of Patients With Pancreatic-Sufficient and Pancreatic-Insufficient Cystic Fibrosis

Репина¹,

Красовский²,

Роживанов³

et al. 2018

Androl. genit. hir.

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Introduction. Cystic fibrosis (CF) is common monogenic disease resulted from CFTR gene mutations. A most of CF male patients are infertile due to the obstructive azoospermia, however, the mechanisms of the reduced fertility in male patients without the obstruction of seminal ducts, also as the influence of CFTR genotype on their development is understudied.Objectiveis to assess an influence the effect of CFTR genotype, clinical form of CF and age on men reproductive system organs, fertility, and testosterone level and semen parameters in male patients with CF. Materials and methods. We examined 71 Russian men (17–39 years old, mean 24.9 ± 5.3) with CF (pancreatic-sufficient, n = 34, and pancreatic-insufficient, n = 37). Clinical, andrology, laboratory and instrumental examination, including scrotal ultrasonography, biochemical semen, and hormonal analyses were performed.Results. Testicular hypoplasia was reveled in 40,5 % CF patients. Diffuse alterations of epididymis, of epididymal and/or testicular cysts were detected in 62 % patients; 10 % of the patients presented symptoms of hypogonadism. As many as 88 % patients showed spermiological signs of bilateral obstruction of seminal ducts at the level of the vas deferens and epididymis, aplasia of the seminal vesicles (azoospermia, oligospermia, low pH and fructose level of the ejaculate). Pancreatic-insufficient CF is an unfavorable prognostic sign for the obstruction of vas deferens, morphological changes in the scrotum. Patients until 25 years (23 %) as 3849+10kb C>T mutation’s carriers (72 %) significantly more frequently presented preserved vas deferens.Conclusion. Pancreatic-sufficient CF, young age and 3849+10kbС>T mutation are favorable factors presented preserved vas deferens and the possible fertility in men with CF.

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“…Pregnancy is more risky for CF patients due to decreased physiological reserve and should be carefully planned [10].…”

Section: Introductionmentioning

confidence: 99%