Contraception in Diabetic Women: Comparative Metabolic Study of Norplant, Depot Medroxyprogesterone Acetate, Low Dose Oral Contraceptive Pill and CuT380A

Diab, Khaled; Zaki, Mona M.

doi:10.1111/j.1447-0756.2000.tb01195.x

Cited by 52 publications

(24 citation statements)

References 16 publications

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“…In a comparative study of norplant and depot medroxyprogesterone acetate (DMPA) in diabetic women, it was found that norplant caused only minimal metabolic changes whilst DMPA was associated with more unfavourable changes [16]. In a comparison of two implants, implanon ® containing etonogestrel (the active metabolite of desogestrel) and norplant containing levonorgestrel acetate, both preparations resulted in similar small effects on the hemostatic system, which were not suggestive of a tendency towards thrombosis [17].…”

Section: Injectable Progestinsmentioning

confidence: 96%

Differential effects of progestins on hemostasis

Schindler

2003

Maturitas

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Section: Injectable Progestinsmentioning

confidence: 96%

Differential effects of progestins on hemostasis

Schindler

2003

Maturitas

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“…Likewise, Diab and Zaki found that fasting blood glucose was higher among users of oral contraceptives and Depo-Provera (depot-medroxyprogesterone acetate, DMPA), a progestogen-only reversible hormonal contraceptive injected every 3 months (9). After reviewing these studies, we hypothesized that an increased risk for GDM would be observed among women who had used hormonal methods of contraception.…”

Section: Introductionmentioning

confidence: 99%

Association Between Contraceptive Use and Gestational Diabetes: Missouri Pregnancy Risk Assessment Monitoring System, 2007–2008

Kramer¹,

Kintzel²,

Garikapaty³

2014

Prev. Chronic Dis.

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IntroductionThe efficacy and safety of contraceptives have been questioned for decades; however, whether a relationship exists between hormonal contraceptives and gestational diabetes (GDM) is undetermined. The aim of this study was to investigate whether maternal risk for GDM was influenced by type of contraceptive method used before pregnancy.MethodsData collected in 2007 and 2008 by the Missouri Pregnancy Risk Assessment Monitoring System (PRAMS) were analyzed to determine if type of contraception before pregnancy influenced maternal risk for GDM. We used a logistic regression model to determine the adjusted odds for GDM given exposure to hormonal forms of contraception.ResultsOf the 2,741 women who completed the 2007–2008 PRAMS survey, 8.3% were diagnosed with gestational diabetes, and 17.9% of the respondents had used hormonal contraceptive methods. Women who used hormonal methods of birth control had higher odds for gestational diabetes (adjusted odds ratio [AOR] = 1.43; 95% confidence interval [CI], 1.32–1.55) than did women who used no contraception. A protective effect was also observed for women who had used barrier methods of contraception (AOR = 0.79; 95% CI, 0.72–0.86).ConclusionFindings suggest there may be a relationship between type of contraceptive method and GDM. More research is needed to verify contraception as a potential risk factor for GDM.

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“…However Diab reported increase in fasting blood sugar in females maintained on OCs and DMPA when compared to Norplant on long term use. This study concluded that in diabetics, Norplant caused minimal metabolic alterations followed by OCs whereas DMPA has unfavorable outcome 10 .…”

Section: Resultsmentioning

confidence: 80%

Untitled

2017

IJPSR

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ABSTRACT:The objective of the current study was to differentiate contraceptives for their effects on carbohydrate metabolism. This is a cross sectional design that was conducted in different clinical settings of urban population who belong to low socio economic status by convenience sampling method. Females representing fertile age ranging from 26 to 32 and maintained on different types of hormonal and non hormonal contraceptives (OC; Oral contraceptives, DMPA; Depo-medroxy progesterone, NET-EN; Norethisterone , Implant and non hormonal intrauterine contraceptive device (IUCD) are enrolled and invited in 12 hrs fasting to give their blood samples. Fasting blood sugar is analyzed by GOD-PAP method. All the readings were fed on MS-Excel to evaluate mean ± S.D, Comparative effects were represented by percentile differences between different groups. The present study concluded that all hormonal and non hormonal methods posed no deleterious effects on carbohydrate metabolism. These minimized risks may be due to young age and good monitoring of therapy in clinical practices and could be threatening in the areas where these are consumed as OTC drugs or by aged females, very near to their menopause or having other risk factors.

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Contraception in Diabetic Women: Comparative Metabolic Study of Norplant, Depot Medroxyprogesterone Acetate, Low Dose Oral Contraceptive Pill and CuT380A

Abstract: In diabetics, Norplant results in minimal metabolic alterations followed by OCs while DMPA has unfavorable outcome.

Cited by 52 publications

References 16 publications

Differential effects of progestins on hemostasis

Differential effects of progestins on hemostasis

Association Between Contraceptive Use and Gestational Diabetes: Missouri Pregnancy Risk Assessment Monitoring System, 2007–2008

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