Contraceptive use and preferences among females with sickle cell disease

Roe, Andrea H.; Lang, Britt; McAllister, Arden; Gaitors, Morine Cebert; Smith‐Whitley, Kim; Schreiber, Courtney A.; Sayani, Farzana

doi:10.1016/j.contraception.2021.08.009

Cited by 20 publications

(23 citation statements)

References 22 publications

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“…13,14 In the U.S. and other high-resource countries, contraception use reported by women with SCD to prevent unplanned pregnancies varies. [14][15][16][17][18][19][20] Low reliability of contraception use and unintended pregnancy are reportedly common in women with SCD. 14 A recent study found that the proportion of women with SCD who used contraception was significantly lower than that of women in the general population.…”

Section: Introductionmentioning

confidence: 99%

“…14 A recent study found that the proportion of women with SCD who used contraception was significantly lower than that of women in the general population. 20 The use of longacting reversible contraception was also reported as low: 5 and 15%…”

Section: Introductionmentioning

confidence: 99%

“…for contraceptive implants and intrauterine devices, respectively. 14,20 Additional pregnancy-related safety concerns exist due to potential teratogenic effects of medications used to treat SCD, especially hydroxyurea. [21][22][23] Despite these concerns, female AYAs with SCD in one study reported only infrequent discussions about contraception and fertility when prescribed hydroxyurea.…”

Section: Introductionmentioning

confidence: 99%

“…A recent study found that the proportion of women with SCD who used contraception was significantly lower than that of women in the general population 20 . The use of long‐acting reversible contraception was also reported as low: 5 and 15% for contraceptive implants and intrauterine devices, respectively 14,20 . Additional pregnancy‐related safety concerns exist due to potential teratogenic effects of medications used to treat SCD, especially hydroxyurea 21–23 .…”

Section: Introductionmentioning

confidence: 99%

“…Despite worse pregnancy outcomes, the proportion of unplanned pregnancies among women with SCD appears to be no different than that of the general population, with almost half reporting having experienced unplanned pregnancy(ies) 13,14 . In the U.S. and other high‐resource countries, contraception use reported by women with SCD to prevent unplanned pregnancies varies 14–20 . Low reliability of contraception use and unintended pregnancy are reportedly common in women with SCD 14 .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Pediatric hematology providers’ contraceptive practices for female adolescents and young adults with sickle cell disease: A national survey

Askew

Smaldone

Gold

et al. 2022

Pediatric Blood & Cancer

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Background: Adolescent and young adult (AYA) women with sickle cell disease (SCD) have increased pregnancy-related health risks and are prescribed potentially teratogenic medications, yet limited data are available regarding pediatric SCD provider contraceptive practices. We aimed to assess pediatric hematology providers' beliefs, practices, motivators, and barriers for providing contraceptive care to female AYAs with SCD.Methods: Guided by the Health Belief Model (HBM), we developed a 25-question, web-based survey to assess practices. Survey links were distributed nationwide to pediatric SCD and/or general hematology providers through their publicly available emails and by request to directors of U.S.-accredited Pediatric Hematology-Oncology fellowship programs for distribution to their SCD providers. Data analysis included descriptive statistics, chi-square analysis, and logistic regression.Results: Of 177 respondents, 160 surveys meeting inclusion criteria were analyzed.Most providers reported counseling (77.5%) and referring female AYA patients for contraception (90.8%), but fewer reported prescribing contraception (41.8%). Proportionally fewer trainees provided counseling compared with established providers (54% vs. 85%, p < .001), with a similar trend for prescribing (p = .05). Prescription practices did not differ significantly by provider beliefs regarding potential teratogenicity of hydroxyurea.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pediatric hematology providers’ contraceptive practices for female adolescents and young adults with sickle cell disease: A national survey

Askew

Smaldone

Gold

et al. 2022

Pediatric Blood & Cancer

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Family planning needs of young adults with sickle cell disease

Linton

Williams

Early

et al. 2023

eJHaem

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Sexual and reproductive healthcare standards for adolescents and young adults with sickle cell disease (SCD) are not established. A total of 50 young adults entering adult SCD care completed a Family Planning Survey assessing sexual and reproductive health needs from March 2019 to July 2020. Clinical data were abstracted from respondents’ electronic medical records. Linear and logistic regression was applied to explore associations between clinical characteristics and survey results. Few respondents (8%) wished to be pregnant in the coming year, and 46% answered yes to at least one of four needs assessment questions. Those who were not employed full time were more likely to endorse needing help with getting sickle cell trait testing for a partner (ORadj = 9.59, p‐value = 0.05). Contraceptive use was associated with having an obstetrician–gynecologist (OR = 6.8, p‐value = 0.01). Young adults with SCD entering adult care have diverse reproductive health needs, highlighting opportunities to provide multidisciplinary, SCD‐specific reproductive healthcare.

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Assessment of menstrual health in adolescent and young adults with sickle cell disease

Notice,

Soffer,

Tickle

et al. 2023

Pediatric Blood & Cancer

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BackgroundSickle cell disease (SCD) is associated with hypercoagulability, but adults with SCD also have an increased incidence of bleeding including heavy menstrual bleeding (HMB). HMB is common among adolescent females, but the impact of HMB in pediatric SCD is unclear. The objectives of this study were to examine menstrual health status, knowledge, and quality of life (QOL).MethodsWe performed a single‐institutional multi‐clinic cross‐sectional study comprised of a five‐part survey in pediatric participants with SCD. The survey included the validated Menstrual Bleeding Questionnaire (MBQ) and Self‐administered Bleeding Assessment Tool (Self‐BAT).ResultsForty‐eight participants with a median age of 16 years (range: 12–21 years) completed the study. The mean age at onset of menarche was 13 ± 1.3 years. On the MBQ, 29% reported heavy/very heavy menstrual flow, 61% reported moderate or severe dysmenorrhea, and 96% had menses lasting less than 1 week. The Self‐BAT revealed that 42% of participants reported a history of HMB. Participants with severe dysmenorrhea or HMB had higher MBQ scores, corresponding to worse QOL. Despite this, less than 20% of participants had attempted any hormonal therapy for menstrual regulation. The odds of hormonal therapy utilization were comparable among participants on hydroxyurea versus not on hydroxyurea (odds ratio 1.58, 95% confidence interval [CI]: 0.33–7.56).ConclusionsThe prevalence of HMB and dysmenorrhea is high among adolescents and young women with SCD. Strategies that incorporate menstrual health assessment into routine medical care in this population would help address this important area of pediatric health.

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Contraceptive use and preferences among females with sickle cell disease

Cited by 20 publications

References 22 publications

Pediatric hematology providers’ contraceptive practices for female adolescents and young adults with sickle cell disease: A national survey

Pediatric hematology providers’ contraceptive practices for female adolescents and young adults with sickle cell disease: A national survey

Family planning needs of young adults with sickle cell disease

Assessment of menstrual health in adolescent and young adults with sickle cell disease

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