2000
DOI: 10.1161/01.cir.102.17.2145
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Contractile Adaptations Preserving Cardiac Output Predispose the Hypertrophied Canine Heart to Delayed Afterdepolarization–Dependent Ventricular Arrhythmias

Abstract: The alterations responsible for improvement in systolic contractile function in CAVB dogs predispose the hypertrophied heart to DAD-dependent triggered arrhythmias during positive inotropic interventions.

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Cited by 73 publications
(51 citation statements)
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“…Cardiomyocytes with elevated [Ca 2ϩ ] i are susceptible to delayed after-depolarizations (DAD). 23) DAD triggered activity is believed to play an important role in arrhythmias. In single myocytes, matrine did not affect the membrane potential and DADs were not observed in the presence of matrine 100 mM.…”
Section: Discussionmentioning
confidence: 99%
“…Cardiomyocytes with elevated [Ca 2ϩ ] i are susceptible to delayed after-depolarizations (DAD). 23) DAD triggered activity is believed to play an important role in arrhythmias. In single myocytes, matrine did not affect the membrane potential and DADs were not observed in the presence of matrine 100 mM.…”
Section: Discussionmentioning
confidence: 99%
“…However, it is conceivable that bradycardia may predispose to cardiomyopathy through a mechanism involving volume overload-induced hypertrophy similar to that observed in the chronic AV block canine model. 27 …”
Section: Functional Divergence and Clinical Heterogeneitymentioning
confidence: 99%
“…Other i to a shift in isoform expression (e.g. in rat [3][4][5][6], in dog indications are an increased contractile response to agents 1 [7,8], and in human [9][10][11] [29]. This contributes to main-7.35 with NaOH).…”
Section: Introductionmentioning
confidence: 99%