Contractile effects of 16-methyl analogues of PGE2 on teh circular and longitudinal muscles of the guinea-pig isolated colon

TNBS-induced inflammation modulates the function of one class of low-threshold rectal mechanoreceptors in the guinea pig

“…PGE 2 did not increase responses of low-threshold mechanoreceptors to activation by von Frey hairs in the present study. PGE 2 evokes increased contractile activity of guinea pig large intestine (12), which suggests that it is not a major mediator involved in TNBS-inhibition of colonic motility.…”

Characterization of the EP receptor types that mediate longitudinal smooth muscle contraction of human colon, mouse colon and mouse ileum

“…Prostaglandin E 2 contracts longitudinal and relaxes circular smooth muscle of human ileum and colon; 9,10 albeit the receptor type(s) that mediate these responses have not been elucidated. Prostaglandin E 2 also contracts longitudinal smooth muscle of rat 11 and guinea‐pig colon 12 . A study using knockout mice, separately lacking each of the eight different prostanoid receptor types, suggested that PGE 2 ‐induced contraction of mouse ileum was mediated by EP 1 and EP 3 receptors with an additional non‐selective effect on FP receptors 13 .…”

Altered Eicosanoid Metabolism in the Cystic Fibrosis Mouse Small Intestine

“…PGE 2 is known to stimulate mucus secretion (55) and excessive mucus production is characteristic of CF ( 6), including both the human and mouse CF intestines (47,56). PGE 2 also is a relaxant for the circular layer of intestinal smooth muscle (57). Increased PGE 2 levels could contribute to the impaired GI motility in many patients with CF (18)(19)(20)(21)(22)(23)(24) and to the dramatically decreased small intestinal transit in the CF mouse (28).…”