Contractile function of the excised hagfish heart during anoxia exposure

Gatrell, L. A.; Farhat, Elie; Pyle, W. Glen; Gillis, Todd E.

doi:10.1007/s00360-019-01208-w

Cited by 6 publications

(2 citation statements)

References 36 publications

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“…Further work has demonstrated that the metabolic rate of the isolated hagfish heart is not affected by up to 16 h of anoxia exposure at 8°C (Gillis et al, 2015), and there is also no difference in the functional parameters of isolated hearts, whether held in anoxia or normoxia over 12 h, at 10°C (Gatrell et al, 2019).…”

Section: Environmental Temperature and The Role Of Metabolic Rate Suppression In Reducing Atp Consumptionmentioning

confidence: 99%

Surviving anoxia: the maintenance of energy production and tissue integrity during anoxia and reoxygenation

Cox

Gillis

2020

Journal of Experimental Biology

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The development of anoxia within tissues represents a significant challenge to most animals because of the decreased capacity for aerobic ATP production, the associated loss of essential cellular functions and the potential for detrimental tissue oxidation upon reoxygenation. Despite these challenges, there are many animals from multiple phyla that routinely experience anoxia and can fully recover. In this Review, we integrate knowledge gained from studies of anoxia-tolerant species across many animal taxa. We primarily focus on strategies used to reduce energy requirements, minimize the consequences of anaerobic ATP production and reduce the adverse effects of reactive oxygen species, which are responsible for tissue damage with reoxygenation. We aim to identify common strategies, as well as novel solutions, to the challenges of anoxia exposure. This Review chronologically examines the challenges faced by animals as they enter anoxia, as they attempt to maintain physiological function during prolonged anoxic exposure and, finally, as they emerge from anoxia. The capacity of animals to survive anoxia is also considered in relation to the increasing prevalence of anoxic zones within marine and freshwater environments, and the need to understand what limits survival.

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Section: Environmental Temperature and The Role Of Metabolic Rate Suppression In Reducing Atp Consumptionmentioning

confidence: 99%

Surviving anoxia: the maintenance of energy production and tissue integrity during anoxia and reoxygenation

Cox

Gillis

2020

Journal of Experimental Biology

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“…Безугла серця. З іншого боку, гіпоксія навантаження може служити за цих умов тригерним механізмом розвитку тривалої системної гіпоксії організму, що негативно впливає на ультраструктуру скелетних м'язів [64] та супроводжується ремоделюванням міокарда [65] зі зниженням його контрактильної функції [66,67].…”

Section: фізіологічні та біохімічні механізми порушення функціонуванн...unclassified

Energy Supply of the Heart and Skeletal Muscles During Exercise: Mitochondrial Vector

Gunina¹,

Belenichev²,

Rosova³

et al. 2022

Fiziol Zh

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In this review, we consider metabolic pathways of energy production from the standpoint of determining the mechanisms of energy supply during intense physical activity and the need to accelerate the process of ATP resynthesis; possible directions of this process intensification are outlined. The most important systems for an athlete to limit his physical performance are the cardiovascular and muscular. That is why we emphasize on energy production in myocardial cells and myocytes. Energy production and energy exchange in cells is carried out by mitochondria, which are the main organelles of energy supply. Functional activity of these organelles is provided by the inner membrane, which contains components of the electron transport chain and ATPase. Physical activity requires ATP resynthesis, which is provided by different types of energyreleased reactions. An important part of our review reveals the analysis of data on the mitochondria themselves, which are key determinants of the functional state of the body’s cells during physical activity. Functional consequences of the changes in mitochondrial structure are of quite importance, especially associated with different configurations of mitochondria and mitochondrium − increasing the number of organelles and crystal density, normalization of the structural and functional state of the inner membrane and its protection from oxidative stress which is inherent in the intense physical activity. Oxidative stress and working hypoxia are a very common cause of further metabolic disorders, even before the formation of hypertrophy of chronic physical exertion, when you have to remove an athlete from the training process. In general, numerous metabolic processes in the myocardium, which are inherent in intense physical activity, undergo negative changes with further activation of athletes. One of the ways to correct energy deficiency caused by prolonged and intense physical activity should be the use of exogenous or endogenous substances involved in energy metabolism.

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Case study: Anoxia tolerance in the Pacific hagfish (Eptatretus stoutii)

Yutsyschyna,

Gillis

2024

Encyclopedia of Fish Physiology

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Contractile function of the excised hagfish heart during anoxia exposure

Cited by 6 publications

References 36 publications

Surviving anoxia: the maintenance of energy production and tissue integrity during anoxia and reoxygenation

Surviving anoxia: the maintenance of energy production and tissue integrity during anoxia and reoxygenation

Energy Supply of the Heart and Skeletal Muscles During Exercise: Mitochondrial Vector

Case study: Anoxia tolerance in the Pacific hagfish (Eptatretus stoutii)

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