Contractile properties of laryngeal muscles in young and old baboons

Mardini, Issam A.; McCarter, Roger; Neal, G. David; Wiederhold, Michael L.; Compton, Charles E.

doi:10.1016/s0196-0709(87)80029-7

Cited by 16 publications

(7 citation statements)

References 12 publications

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“…V max represents the average maximal shortening speed of all fibers in a heterogeneous muscle (7,8). Our data confirm the decrease in V max found previously in laryngeal muscles of old baboons (26). The change in V max could be due to a shift in the distribution of fiber types present in the thyroarytenoid muscles, for example, an increase in the number of slow fibers.…”

Section: Contractile Dysfunctionsupporting

confidence: 89%

Contractile dysfunction and altered metabolic profile of the aging rat thyroarytenoid muscle

McMullen¹,

Andrade²

2006

Journal of Applied Physiology

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The larynx and its muscles are important for ventilation, coughing, sneezing, swallowing, Valsalva's maneuver, and phonation. Because of their functional demands, the intrinsic laryngeal muscles have a unique phenotype: very small and fast fibers with high mitochondrial content. How aging affects their function is largely unknown. In this study, we tested the hypothesis that an intrinsic laryngeal muscle (thyroarytenoid muscle, a vocal fold adductor) would become weaker, slower, and fatigable with age. Muscles from Fischer 344 x Brown Norway F1 hybrid rats (6, 18, and 30 mo of age) were used for in vitro contractile function and histology. Thyroarytenoid muscles generated significantly lower twitch and tetanic forces at 30 mo vs. 6 and 18 mo. Maximal shortening velocity decreased by 20% at 30 mo (vs. 6 mo), and velocity of unloaded shortening was slower at 18 and 30 mo by 19 and 27% vs. 6 mo. There was no histochemical evidence of altered myosin ATPase activity at 18 or 30 mo of age. Fatigue resistance was significantly decreased at 18 and 30 mo. We also found abundant mitochondrial clusters and ragged red fibers in the muscles of 30-mo-old rats, and there was an age-related increase in glycogen-positive fibers. We conclude that rat thyroarytenoid muscles become weaker, slower, and more fatigable with age. These functional changes are not due to alterations in myosin ATPase activity, but a switch in the expression of myosin isoforms remains a possibility. Finally, the alterations in mitochondrial and glycogen content indicate a shift in the metabolic characteristics of these muscles with age.

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Section: Contractile Dysfunctionsupporting

confidence: 89%

Contractile dysfunction and altered metabolic profile of the aging rat thyroarytenoid muscle

McMullen¹,

Andrade²

2006

Journal of Applied Physiology

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“…The cause of dysphagia in older age may be of neural origin or due to a dysfunction of the muscles or changes in the morphology of the larynx [Mardini et al, 1987]. Enlargement of a part of the hyoid bone may occasionally cause clinical symptoms, such as pain upon swallowing or opening the jaw [Lykaki et al, 1988;Morrissey et al, 1989;Hilali et al, 1997].…”

Section: Introductionmentioning

confidence: 99%

Age-Related Morphological Changes in the Human Hyoid Bone

Shimizu¹,

Kanetaka²,

Kim

et al. 2005

Cells Tissues Organs

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Object: Age-related morphological changes in the human hyoid bone were investigated radiographically and histologically. Materials and Methods: Thirty-two measurements were performed on radiographs of 238 hyoid bones from autopsy cases of known age and sex. Thirty-one hyoid bones that were studied by radiography were also examined histologically in horizontal sections. Results: Analysis of the length and width of the hyoid bone revealed significant increases in the body and the anterior part of the greater cornu and a significant decrease in the posterior part of the greater cornu with aging. Most measurements of the body and the greater cornu revealed differences between male and female hyoid bones. The outer margins of the body and the greater cornu were situated further outside in older males compared with females. The breadth of the joint space showed a significant age-related decrease, and the degree of fusion showed a significant age-related increase. Histological findings showed ossified or calcified fusion, with osteoclasts in the marginal area of the joint space. Conclusions: Increasing age induces fusion of the body and the greater cornu. The morphometric changes in the shape of the hyoid bone may represent functional adaptation to articulation fixation.

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“…These aging muscle changes may occur more generally in the animal kingdom, as evidenced by Mardini (1987), who found that in an aging baboon, the TA muscle contracted more slowly, fatigued more readily, and took longer to recover than in younger animals. In rats and humans, who have been studied most extensively, TA muscle changes have been postulated to result from arteriosclerotic changes in the vessels (Ferreri 1959; Hommerich 1972) or from disturbance in sympathetic innervations (Bach et al 1942).…”

Section: Normal Vocal Agingmentioning

confidence: 99%

“…The TA muscle – the principal muscle of the vocal fold – has been studied extensively in the last two decades. Its involution has been attributed to atrophy which has been causally linked to altered metabolic processes (Kersing and Jennekens 2004), aging contractile proteins (Mardini et al 1987), alteration in fiber type composition (Rodeno et al 1993; Malmgren et al 1999; Suzuki et al 2002) and degenerative changes caused by subtle amounts of denervation and poor or inefficient reconstitution of NMJs (Prakash and Sieck 1998). Sato and Tauchi (1982) found that aging appeared to have a differential effect on fiber types within the TA muscle.…”

Section: Normal Vocal Agingmentioning

confidence: 99%

Vocal aging and adductor spasmodic dysphonia: Response to botulinum toxin injection

Cannito

Kahane²,

Chorna³

2008

CIA

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Abstract:Aging of the larynx is characterized by involutional changes which alter its biomechanical and neural properties and create a biological environment that is different from younger counterparts. Illustrative anatomical examples are presented. This natural, non-disease process appears to set conditions which may infl uence the effectiveness of botulinum toxin injection and our expectations for its success. Adductor spasmodic dysphonia, a type of laryngeal dystonia, is typically treated using botulinum toxin injections of the vocal folds in order to suppress adductory muscle spasms which are disruptive to production of speech and voice. A few studies have suggested diminished response to treatment in older patients with adductor spasmodic dysphonia. This retrospective study provides a reanalysis of existing pre-to-post treatment data as function of age. Perceptual judgments of speech produced by 42 patients with ADSD were made by two panels of professional listeners with expertise in voice or fl uency of speech. Results demonstrate a markedly reduced positive response to botulinum toxin treatment in the older patients. Perceptual fi ndings are further elucidated by means of acoustic spectrography. Literature on vocal aging is reviewed to provide a specifi c set of biological mechanisms that best account for the observed interaction of botulinum toxin treatment with advancing age.

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Contractile properties of laryngeal muscles in young and old baboons

Cited by 16 publications

References 12 publications

Contractile dysfunction and altered metabolic profile of the aging rat thyroarytenoid muscle

Contractile dysfunction and altered metabolic profile of the aging rat thyroarytenoid muscle

Age-Related Morphological Changes in the Human Hyoid Bone

Vocal aging and adductor spasmodic dysphonia: Response to botulinum toxin injection

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