Let V 10 be a 10-dimensional complex vector space and let σ ∈ 3 V ∨ 10 be a non-zero alternating 3-form. One can define several associated degeneracy loci: the Debarre-Voisin variety X σ 6 ⊂ Gr(6, V 10 ), the Peskine variety X σ 1 ⊂ P(V 10 ), and the hyperplane section X σ 3 ⊂ Gr(3, V 10 ). Their interest stems from the fact that the Debarre-Voisin varieties form a locally complete family of projective hyperkähler fourfolds of K3 [2] -type. We prove that when smooth, the varieties X σ 6 , X σ 1 , and X σ 3 share one same integral Hodge structure, and that X σ 1 and X σ 3 both satisfy the integral Hodge conjecture in all degrees. This is obtained as a consequence of a detailed analysis of the geometry of these varieties along three divisors in the moduli space. On one of the divisors, an associated K3 surface S of degree 6 can be constructed geometrically and the Debarre-Voisin fourfold is shown to be isomorphic to a moduli space of twisted sheaves on S, in analogy with the case of cubic fourfolds containing a plane.