Contralateral lymph neck node metastasis of primary squamous cell carcinoma of the tongue: a retrospective analytic study of 203 patients

González-García, Raúl; Naval-Gías, Luis; Sastre-Pérez, Jesús; Rodríguez-Campo, F.J.; Muñoz-Guerra, M.F.; Usandizaga, J.L. Gil-Díez; Díaz-González, F.J.

doi:10.1016/j.ijom.2007.01.008

Cited by 27 publications

(29 citation statements)

References 19 publications

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“…Some authors recognize that contralateral metastases of head and neck carcinomas can occur in different ways: firstly, by crossing afferent lymph vessels; and second by tumor spreading over the midline to reach efferent collateral lymphatic vessels while ipsilateral lymph nodes are extensively involved, where there is not a real midline barrier in certain anatomic areas [7]. The incidence of CLNM differs considerably among institutions from 0.9% to 36% [6,[8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Incidence Of Clnm In Osccmentioning

confidence: 99%

“…However, results of a few previous studies have suggested that histological grading is a significant and independent predictor for cervical lymph node metastasis in head and neck SCC [13,17,[74][75][76]. It was also reported that a higher degree of histopathological grading created at a higher risk for CLNM in SCC of oral cavity [13,[18][19].…”

Section: Histological Gradingmentioning

confidence: 99%

“…To the best of our knowledge, no report has considered the possible correlation between CLNM and desmoplastic reaction, but a few have reported that desmoplastic reaction and peritumoral inflammation are significant predictive factors of cervical metastasis [17,43,93]. Gonzá lez-Garcí a et al [17] reported that peritumoral inflammation was statistically significant in relation to CLNM in a retrospective analytic study of 203 patients with SCC of the tongue.…”

Section: Desmoplastic Reaction and Peritumoral Inflammationmentioning

confidence: 99%

“…Gonzá lez-Garcí a et al [17] reported that peritumoral inflammation was statistically significant in relation to CLNM in a retrospective analytic study of 203 patients with SCC of the tongue. They offer a possible explanation for this association that a low host immunological response around the primary tumor could allow easier dissemination of cancer cells through lymphatic drainage.…”

Section: Desmoplastic Reaction and Peritumoral Inflammationmentioning

confidence: 99%

“…I: tumors arising in the base of tongue and the floor of the mouth [6-8, 21, 34]; II: tumors crossing the midline [6, 17-18, 29, 99]; III: advanced staging (cT3-4) [8,11,13,15,[17][18]29]; IV: primary tumor more than 3.75 mm thick [20]; V: multiple ipsilateral nodes involvement [8,13,21,29].…”

Section: Neck Dissectionmentioning

confidence: 99%

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A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma

et al. 2011

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Oral squamous cell carcinoma (OSCC) has a high incidence of cervical micrometastases and sometimes metastasizes contralaterally because of the rich lymphatic intercommunications relative to submucosal plexus of oral cavity that freely communicate across the midline, and it can facilitate the spread of neoplastic cells to any area of the neck consequently. Clinical and histopathologic factors continue to provide predictive information to contralateral neck metastases (CLNM) in OSCC, which determine prophylactic and adjuvant treatments for an individual patient. This review describes the predictive value of clinical-histopathologic factors, which relate to primary tumor and cervical lymph nodes, and surgical dissection and adjuvant treatments. In addition, the indications for elective contralateral neck dissection and adjuvant radiotherapy (aRT) and strategies for follow-up are offered, which is strongly focused by clinicians to prevent later CLNM and poor prognosis subsequently.

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Section: Incidence Of Clnm In Osccmentioning

confidence: 99%

Section: Histological Gradingmentioning

confidence: 99%

Section: Desmoplastic Reaction and Peritumoral Inflammationmentioning

confidence: 99%

Section: Desmoplastic Reaction and Peritumoral Inflammationmentioning

confidence: 99%

Section: Neck Dissectionmentioning

confidence: 99%

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A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma

et al. 2011

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Local recurrences and second primary tumors from squamous cell carcinoma of the oral cavity: A retrospective analytic study of 500 patients

et al. 2009

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The identification of preoperative and postoperative clinical and pathological features that prelude a higher risk for the appearance of LRs and/or SPTs may be of potential interest in determining which patients should benefit of a closer regular follow-up. When considering together the whole clinical and pathological features, only postoperative RT and bone involvement were predictive for the development of LRs. Because of the poor survival rate of the affected patients, we strongly recommend aggressive surgical treatment following the appearance of an SPT or LR.

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Ipsilateral neck nodal status as predictor of contralateral nodal metastasis in carcinoma of tongue crossing the midline

Singh

Nair

et al. 2012

Head & Neck

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Contralateral lymph neck node metastasis of primary squamous cell carcinoma of the tongue: a retrospective analytic study of 203 patients

Cited by 27 publications

References 19 publications

A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma

A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma

Local recurrences and second primary tumors from squamous cell carcinoma of the oral cavity: A retrospective analytic study of 500 patients

Ipsilateral neck nodal status as predictor of contralateral nodal metastasis in carcinoma of tongue crossing the midline

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