Contralateral Prophylactic Mastectomy in Patients with Breast Cancer

Noditi, Aniela; Caragheorghe, George; Stoleru, Smaranda; Blidaru, Alexandru; Bordea, C

doi:10.21614/chirurgia.116.2suppl.s73

Cited by 3 publications

(2 citation statements)

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“…The rate of PME in the contralateral breast in patients with cancer continues to rise [13]. The highest rate of prophylactic mastectomy is reported in the United States (36.3%), whereas Poland has the lowest rate (2.7%) [14].…”

Section: Introductionmentioning

confidence: 99%

Prophylactic mastectomies in patients with breast cancer and known germline pathogenetic variants: an Austrian registry

Leser,

Deutschmann,

Dorffner

et al. 2024

Preprint

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Objectives Risk-reducing surgeries are common in patients with breast cancer gene (BRCA) mutations. Certain patients develop breast cancer before they opt for these surgeries. We aimed to examine the frequency of risk-reducing mastectomies and salpingo-oophorectomy among Austrian patients with breast cancer and BRCA mutations. Methods In 2014, we established an Austrian registry with patients with known germline pathogenetic variants. From onset until 2018, 111 patients were recruited from four breast cancer centers. Data on the type of mastectomy, reconstructions, and complications were collected. Results Of all patients, 13.5% had bilateral breast cancer. Among patients with unilateral breast cancer, the majority (86.8%) opted for prophylactic mastectomy on the contralateral side. Those who underwent modified radical mastectomy were more likely to choose prophylactic surgery (p = 0.001). A total of 19.4% of patients experienced cancer relapse postoperatively. Immediate reconstructions were recorded in 71.3% of the patients. In addition, patients undergoing immediate reconstruction were more likely to undergo a prophylactic operation on the contralateral side than those with delayed reconstruction (p = 0.001). A mesh was used in 47.8% of all reconstructions. The subpectoral implant was present in 75.6% of patients and the pre-pectoral in 13.3%. A mesh was inserted in all patients with pre-pectoral implants. Conclusion The results indicate that the willingness for risk-reducing surgeries is high and the option for immediate reconstruction is preferably selected by the patients with breast cancer.

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Section: Introductionmentioning

confidence: 99%

Prophylactic mastectomies in patients with breast cancer and known germline pathogenetic variants: an Austrian registry

Leser,

Deutschmann,

Dorffner

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The highest rate of prophylactic mastectomy is reported in the United States (36.3%), whereas Poland has the lowest rate (2.7%) [11]. The rate of PME in the contralateral breast of patients with cancer continues to rise [12].…”

Section: Introductionmentioning

confidence: 99%

Prophylactic mastectomies and bilateral salpingo-oophorectomies in patients with breast cancer and BRCA mutation: an Austrian registry

Leser,

Deutschmann,

Dorffner

et al. 2023

Preprint

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Objectives Risk-reducing surgeries are common in patients with breast cancer gene (BRCA) mutations. Certain patients develop breast cancer before they opt for these surgeries. We examined the frequency of risk-reducing mastectomies and salpingo-oophorectomy among Austrian patients with breast cancer and BRCA mutations. Methods In 2014, we established an Austrian registry of BRCA1 and BRCA2 mutation carriers. From onset until 2018, 111 patients were recruited from four breast cancer centers. Data on the type of mastectomy, reconstructions, and complications were collected. Results A small proportion of patients (13.5%) had bilateral breast cancer. Among patients with unilateral breast cancer, the majority (86.8%) opted for prophylactic mastectomy on the contralateral side. Those who underwent modified radical mastectomy were more likely to choose prophylactic surgery (p = 0.001). A total of 19.4% of patients experienced cancer relapse postoperatively. Immediate reconstructions were recorded (71.3%). In addition, patients undergoing immediate reconstruction were more likely to undergo a prophylactic operation on the contralateral side than those with delayed reconstruction (p = 0.001). A mesh was used in only 47.8% of all reconstructions. The subpectoral implant position was present in 75.6% of patients and the pre-pectoral position in 13.3%. A mesh was inserted in all patients with a the pre-pectoral implant position. Conclusion The results indicate that the patients understood the procedures considering their willingness for risk-reducing surgeries and the expectation of good cosmetic outcomes in immediate reconstructions.

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EBCC-13 manifesto: Balancing pros and cons for contralateral prophylactic mastectomy

Schmidt¹,

Kelly²,

Brédart³

et al. 2023

European Journal of Cancer

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Contralateral Prophylactic Mastectomy in Patients with Breast Cancer

Cited by 3 publications

References 0 publications

Prophylactic mastectomies in patients with breast cancer and known germline pathogenetic variants: an Austrian registry

Prophylactic mastectomies in patients with breast cancer and known germline pathogenetic variants: an Austrian registry

Prophylactic mastectomies and bilateral salpingo-oophorectomies in patients with breast cancer and BRCA mutation: an Austrian registry

EBCC-13 manifesto: Balancing pros and cons for contralateral prophylactic mastectomy

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