Contrast agents for MRI based on iron oxide nanoparticles prepared by laser pyrolysis

Morales, M.P.; Miguel, Óscar; Alejo, Rigoberto Pérez de; Ruíz-Cabello, Jesús; Veintemillas-Verdaguer, Sabino; O’Grady, K.

doi:10.1016/s0304-8853(03)00461-x

Cited by 106 publications

(64 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in contrast to previous studies that show a steady increase in the relaxivity with increasing particle size through 15 nm [38]. Part of this discrepancy may arise from the observed frequency at which these experiments were performed (400 MHz versus 40 to 60 MHz).…”

Section: Particle Size Versus Relaxationcontrasting

confidence: 91%

Bioagent detection using miniaturized NMR and nanoparticle amplification : final LDRD report.

Clewett¹,

Adams²,

Fan³

et al. 2006

View full text Add to dashboard Cite

This LDRD program was directed towards the development of a portable micro-nuclear magnetic resonance (µ-NMR) spectrometer for the detection of bioagents via induced amplification of solvent relaxation based on superparamagnetic nanoparticles. The first component of this research was the fabrication and testing of two different micro-coil (µ-coil) platforms: namely a planar spiral NMR µ-coil and a cylindrical solenoid NMR µ-coil. These fabrication techniques are described along with the testing of the NMR performance for the individual coils. The NMR relaxivity for a series of water soluble FeMn oxide nanoparticles was also determined to explore the influence of the nanoparticle size on the observed NMR relaxation properties. In addition, The use of commercially produced superparamagnetic iron oxide nanoparticles (SPIONs) for amplification via NMR based relaxation mechanisms was also demonstrated, with the lower detection limit in number of SPIONs per nanoliter (nL) being determined.* Author to whom correspondence should be addressed: tmalam@sandia.gov 4 AcknowledgementsThe progress made in this LDRD project is the result of contributions from a number of team members both here at Sandia National Laboratories, at the University of New Mexico and the company New Mexico Resonance. These members include C. The development and testing of two different µ-coil platforms for nuclear magnetic resonance (NMR) detection were completed under this LDRD project. The performance of these NMR µ-coils allowed the demonstration of SPION (superparamagnetic iron oxide nanoparticle) amplification via induced changes in the NMR relaxation rates of the carrier solvent water. A detection limit of 10 particles/nL was experimentally measured for the first prototype solenoid µ-coil design. These results clearly show that nanoparticle amplification for µ-NMR can be used for detection of bioagents. List of Tables

show abstract

Section: Particle Size Versus Relaxationcontrasting

confidence: 91%

Bioagent detection using miniaturized NMR and nanoparticle amplification : final LDRD report.

Clewett¹,

Adams²,

Fan³

et al. 2006

View full text Add to dashboard Cite

show abstract

“…The magnetic latexes have the advantage of rapid and easy separation of particles upon the application of an external magnetic field [31 ] and demonstrate potential applications in biomédical and diagnostics fields, including cellular therapy in cell labeling [32], drug delivery [33], cell separation [34], biosensors [35], immobilization of biomolecules such as oligonucleotides [36], proteins [37] and antibodies [38]. In order to successfully apply magnetic latexes to biomédical fields, it is necessary to obtain magnetic polymer particles with properties of no sedimentation [39], near-nanosized distribution [40], high and uniform superparamagnetic content [41], no iron leaking and non-toxicity [42].…”

Section: Applicationsmentioning

confidence: 99%

Double Miniemulsion Preparation for Hybrid Latexes

Hong

Liu

Feng

et al. 2010

Miniemulsion Polymerization Technology

View full text Add to dashboard Cite

“…It has also been reported that dextran -coated nanoparticles can form larger aggregates with a hydrodynamic diameter of approximately 50 nm. It has been observed that increases occurred in the saturation magnetization, total susceptibility, and both the r 1 and r 2 relaxivities of the nanoparticle suspensions with an increase in nanocrystal size [75] . A new ferrofl uid based on dextran -coated iron metal particles with aggregate sizes close to 50 nm has also been reported.…”

Section: Modifi Cation Using Polymeric Stabilizersmentioning

confidence: 99%

“…Morales and coworkers [75] presented their results of studies with dextranstabilized iron oxide nanoparticle cluster suspensions, where the primary particle core (produced by the laser -induced pyrolysis of iron pentacarbonyl vapors) was varied in size. The clusters were typically 50 -100 nm in size, but the strongest determinant of an increased r 2 / r 1 ratio was found to be the primary particle size.…”

Section: General Application Of Relaxation Time Measurementsmentioning

confidence: 99%

Magnetic Nanomaterials asMRIContrast Agents

Gun’ko

Brougham

2009

Nanotechnologies for the Life Sciences

View full text Add to dashboard Cite

The sections in this article are Introduction Classification of Magnetic Nanomaterials Used for MRI Applications Magnetic Oxide‐Based Nanoparticles Magnetic Metal‐ and Alloy‐Based Nanoparticles as Contrast Agents Rare Earth Metal‐Loaded Nanoparticulate Contrast Agents Coating and Surface Functionalization of Magnetic Nanoparticles Surface Modification with Monomeric Stabilizers Modification Using Polymeric Stabilizers Modification Using Inorganic Coatings Vectorization of Magnetic Nanomaterials for Targeted Imaging Properties and Characterization of Magnetic Nanoparticle Suspensions Characterizing the Suspensions Nanoparticle Size: Transmission Electron Microscopy Magnetic Properties: Magnetometry Hydrodynamic Size: Photon Correlation Spectroscopy Magnetic Resonance Properties: Nuclear Magnetic Resonance Dispersion NMR Relaxation in the Presence of Superparamagnetic Nanoparticles SPM Theory Applied to Suspensions of Nanoparticle Clusters General Application of Relaxation Time Measurements Application of Magnetic Nanomaterials in MRI Current Clinical Applications Gastrointestinal Tract and Bowel Imaging Liver and Spleen Imaging Lymph Node Imaging Bone Marrow Imaging Brain Imaging Blood Pool Imaging and MR Angiography Atherosclerosis Imaging Potential Clinical Applications Cellular Labeling and Tracking Molecular Imaging Summary and Future Outlook Improved Imaging Methods Improved Imaging Hardware Improved Contrast Agents

show abstract

Contrast agents for MRI based on iron oxide nanoparticles prepared by laser pyrolysis

Cited by 106 publications

References 12 publications

Bioagent detection using miniaturized NMR and nanoparticle amplification : final LDRD report.

Bioagent detection using miniaturized NMR and nanoparticle amplification : final LDRD report.

Double Miniemulsion Preparation for Hybrid Latexes

Magnetic Nanomaterials asMRIContrast Agents

Contact Info

Product

Resources

About