Contrast echocardiography for pulmonary blood volume quantification

Mischi, Massimo; Kalker, Ton; Korsten, Erik

doi:10.1109/tuffc.2004.1334846

Cited by 52 publications

(74 citation statements)

References 24 publications

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“…Following the injection, a dynamic series of images was acquired. Based on the linear relationship between CA concentration and MR signal [30], indicator dilution curves were derived and used to fit the local density random walk (LDRW) model [38]. Intra-thoracic transit time (ITT) was determined as the difference between the mean transit times of the left and the right ventricular indicator dilution curves.…”

Section: Cardiac Magnetic Resonance Imagingmentioning

confidence: 99%

Monitoring thoracic fluid content using bioelectrical impedance spectroscopy and Cole modeling

Dovancescu

Saporito

Herold

et al. 2017

Journal of Electrical Bioimpedance

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Heart failure is a chronic disease marked by frequent hospitalizations due to pulmonary fluid congestion. Monitoring the thoracic fluid status may favor the detection of fluid congestion in an early stage and enable targeted preventive measures. Bioelectrical impedance spectroscopy (BIS) has been used in combination with the Cole model for monitoring body composition including fluid status. The model parameters reflect intracellular and extracellular fluid volume as well as cell sizes, types and interactions. Transthoracic BIS may be a suitable approach to monitoring variations in thoracic fluid content.The aim of this study was to identify BIS measures, which can be derived based on the Cole model, that are sensitive to early stages of thoracic fluid accumulation. We simulated this medical condition in healthy subjects by shifting a part of the whole blood from the periphery towards the thorax. The redistribution of blood was achieved non-invasively through leg compression using inflatable leg sleeves. We acquired BIS data before, during and after compression of the legs and examined the effect of thoracic fluid variations on parameters derived based on the Cole model and on geometrical properties of the impedance arc. Indicator dilution measurements obtained through cardiac magnetic resonance imaging were used as a reference for the changes in pulmonary fluid volume.Eight healthy subjects were included in the study. The Cole model parameters of the study group at baseline were: R 0 = 51.4 ± 6.7 Ω, R ∞ = 25.0 ± 7.0 Ω, f c = 49.0 ± 10.5 kHz, α = 0.687 ± 0.027, the resistances of individual fluid compartments were R E = 51.4 ± 6.7 Ω, R I = 50.5 ± 22.9 Ω, the fluid distribution ratio was K = 1.1 ± 0.3, and the radius, area and depression of the arc's center were: R = 15.7 ± 1.3 Ω, X C = −8.5 ± 1.5 Ω, A = 134.0 ± 15.6 Ω 2 . The effect of leg compression was a relatively small, reversible increase in pulmonary blood volume of 90 ± 57 mL. We observed significant changes in parameters associated with intracellular, extracellular and total fluid volume (R 0 : -1.5 ± 0.9 %, p < 0.01; R ∞ : −2.1 ± 1

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Section: Cardiac Magnetic Resonance Imagingmentioning

confidence: 99%

Monitoring thoracic fluid content using bioelectrical impedance spectroscopy and Cole modeling

Dovancescu

Saporito

Herold

et al. 2017

Journal of Electrical Bioimpedance

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“…Usually the SNR of measured IDCs is very low (SNR = 20 log(A max /N ) 15 dB, where A max and N are the IDC maximum amplitude and the noise amplitude respectively [18], [19]) and the definition of the right samples to estimate C i and C i+1 is critical. A better approach is the use of an IDC model interpolation.…”

Section: A Ejection Fraction Measurementmentioning

confidence: 99%

“…In order to ensure a linear relation between contrast concentration and acoustic backscatter, the injected dose of contrast is very small (0.5 mg of SonoVue , Bracco, Milan, Italy) [19]. In fact, the integrated acoustic backscatter is linearly related to contrast concentration in the lowconcentration range [22], [32], [33], [36].…”

Section: B Ultrasound Contrast Agent Dilution Curvesmentioning

confidence: 99%

“…In fact, if two boluses of mass equal to αM and βM are injected (α, β ∈ R), the detected IDC, as from all the IDC models [18], [19], [21], [34], [35], equals αC(t) + βC(t). Therefore, once the LA and LV ultrasound intensity curves are transformed into IDCs by compensating for all the nonlinear effects, they can be used as inputs of a deconvolution algorithm for the estimation of the LV dilution-system impulse response [39].…”

Section: LV Impulse Response Estimationmentioning

confidence: 99%

“…The acoustic backscatter is related to the contrast concentration and can be used to generate IDCs. The UCA IDCs usually are interpreted by means of indicator dilution models, such as gamma variate, lognormal, compartmental, or random walk models, which are directly fitted to the curves [18], [19], [21], [34], [35].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Identification of ultrasound contrast agent dilution systems for ejection fraction measurements

Mischi

Jansen

Kalker

et al. 2005

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Intra‐thoracic blood volume measurement by contrast magnetic resonance imaging

Mischi¹,

Bosch²,

Boer³

et al. 2009

Magnetic Resonance in Med

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The intra-thoracic blood volume (ITBV) is a cardiovascular parameter related to the cardiac preload and left ventricular function. Its assessment is, therefore, important for diagnosis and follow-up of several cardiovascular dysfunctions. Nowadays, the ITBV can be accurately measured only by invasive indicator dilution techniques, which require a double catheterization of the patient. In this study, a novel technique is presented for ITBV assessment by dynamic magnetic resonance imaging after intravenous injection of a small bolus of gadolinium chelate.

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Contrast echocardiography for pulmonary blood volume quantification

Abstract: Abstract-Pulmonary

Cited by 52 publications

References 24 publications

Monitoring thoracic fluid content using bioelectrical impedance spectroscopy and Cole modeling

Monitoring thoracic fluid content using bioelectrical impedance spectroscopy and Cole modeling

Identification of ultrasound contrast agent dilution systems for ejection fraction measurements

Intra‐thoracic blood volume measurement by contrast magnetic resonance imaging

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