Contrast‐enhanced first pass myocardial perfusion imaging: Correlation between myocardial blood flow in dogs at rest and during hyperemia

Wilke, Norbert; Simm, C.; Zhang, J.; Ellermann, Jutta; Ya, Xiong; Merkle, Hellmut; Path, G.; Ludemann, Henry H.; Bache, Robert J.; Uğurbil, Kâmil

doi:10.1002/mrm.1910290410

Cited by 332 publications

(202 citation statements)

References 26 publications

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“…Reduced signal intensity on first-pass MRI contrast images has been shown to be associated with reduced blood flow, 4 although this relationship may not be linear when higher doses of extravascular gadolinium-based MRI contrast agents are used. 13 In infarct regions, however, microvascular myocardial blood flow may not return to normal even after epicardial revascularization, 14 the so-called no-reflow phenomenon.…”

Section: Discussionmentioning

confidence: 99%

“…A number of interrelated factors, including reduced regional blood flow, 4,5,15 increased capillary permeability, 16 and increased interstitial volume, 17 may produce HYPER within viable but previously ischemic myocardium. In the present study, HYPER differed in both contrast enhancement pattern and late myocardial function compared with HYPO, COMB, or REMOTE.…”

Section: Discussionmentioning

confidence: 99%

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Early Contrast-Enhanced MRI Predicts Late Functional Recovery After Reperfused Myocardial Infarction

et al. 1999

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Background-We have observed 3 abnormal patterns on contrast-enhanced MRI early after reperfused myocardial infarction (MI): (1) absence of normal first-pass signal enhancement (HYPO), (2) normal first pass signal followed by hyperenhanced signal on delayed images (HYPER), or (3) both absence of normal first-pass enhancement and delayed hyperenhancement (COMB). This study examines the association between these patterns in the first week after MI and late recovery of myocardial contractile function by use of magnetic resonance myocardial tissue tagging. Methods and Results-Seventeen patients (14 men) with a mean age of 53Ϯ12 years were studied after a reperfused first MI. Contrast-enhanced images were acquired immediately after bolus administration of gadolinium and 7Ϯ2 minutes later. Tagged images were acquired at weeks 1 and 7. Circumferential segment shortening (%S) was measured in regions displaying HYPER, COMB, or HYPO contrast patterns and in remote regions (REMOTE) at weeks 1 and 7. At week 1, %S was depressed in HYPER, COMB, and HYPO (9Ϯ8%, 7Ϯ6%, and 5Ϯ4%, respectively) and were less than REMOTE (18Ϯ6%, PϽ0.003). However, in HYPER, %S improved at week 7 from 9Ϯ8% to 18Ϯ5% (PϽ0.001 versus week 1). In contrast, HYPO did not improve significantly (5Ϯ4% to 6Ϯ3%, PϭNS) and COMB tended to improve 7Ϯ6% to 11Ϯ6% (Pϭ0.06). Conclusions-HYPER

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Early Contrast-Enhanced MRI Predicts Late Functional Recovery After Reperfused Myocardial Infarction

et al. 1999

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“…6 -12 Parameters for the assessment of myocardial perfusion are usually gained by analyzing the first pass of a contrast agent bolus through the myocardium. 6,9,13,14 With extensive modeling, quantitative determination of myocardial perfusion is possible; however, this approach relies on several assumptions that may not be fulfilled in patients. 13,[15][16][17] We have recently shown that a linear fit of the upslope is easy to perform, is highly reproducible, and shows promising accuracy in a selected patient population.…”

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confidence: 99%

Magnetic Resonance Perfusion Measurements for the Noninvasive Detection of Coronary Artery Disease

et al. 2003

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Background-With MRI, an index of myocardial perfusion reserve (MPRI) can be determined. We assessed the value of this technique for the noninvasive detection of coronary artery disease (CAD) in patients with suspected CAD. Methods and Results-Eighty-four patients referred for a primary diagnostic coronary angiography were examined with a 1.5 T MRI tomograph (Philips-ACS). For each heartbeat, 5 slices were acquired during the first pass of 0.025 mmol gadolinium-diethylenetriamine pentaacetic acid/kg body weight before and during adenosine vasodilation by using a turbo-gradient echo/echo-planar imaging-hybrid sequence. MPRI was determined from the alteration of the upslope of the myocardial signal intensity curves for 6 equiangular segments per slice. Receiver operating characteristics were performed for different criteria to differentiate ischemic and nonischemic segments. Prevalence of CAD was 51%. Best results were achieved when only the 3 inner slices were assessed and a threshold value of 1.1 was used for the second smallest value as a marker for significant CAD. This approach yielded a sensitivity of 88%, specificity of 90%, and accuracy of 89%. Conclusion-The determination of MPRI with MRI yields a high diagnostic accuracy in patients with suspected CAD.(Circulation. 2003;108:432-437.)

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“…One possible approach to assess perfusion with MRI is contrast-enhanced first pass perfusion imaging (7). The basic principle is the tracking of the signal intensity change after the i.v.…”

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confidence: 99%

In vivo assessment of absolute perfusion and intracapillary blood volume in the murine myocardium by spin labeling magnetic resonance imaging

Streif¹,

Nahrendorf²,

Hiller³

et al. 2005

Magnetic Resonance in Med

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The absolute perfusion and the intracapillary or regional blood volume (RBV) in murine myocardium were assessed in vivo by spin labeling magnetic resonance imaging. Pixel-based perfusion and RBV maps were calculated at a pixel resolution of 469 ؋ 469 m and a slice thickness of 2 mm. The T 1 imaging module was a segmented inversion recovery snapshot fast low angle shot sequence with velocity compensation in all three gradient directions. The group average myocardial perfusion at baseline was determined to be 701 ؎ 53 mL (100 g ⅐ min) ؊1 for anesthesia with isoflurane (N ‫؍‬ 11) at a mean heart rate (HR) of 455 ؎ 10 beats per minute (bpm). This value is in good agreement with perfusion values determined by invasive microspheres examinations. For i.v. administration of the anesthetic Propofol, the baseline perfusion decreased to 383 ؎ 40 mL (100 g ⅐ min) ؊1 (N ‫؍‬ 17, P < 0.05 versus. isoflurane) at a mean heart rate of 261 ؎ 13 bpm (P < 0.05 versus isoflurane). In addition, six mice with myocardial infarction were studied under isoflurane anesthesia (HR 397 ؎ 7 bpm). The perfusion maps showed a clear decrease of the perfusion in the infarcted area. The perfusion in the remote myocardium decreased significantly to 476 ؎ 81 mL (100 g ⅐ min) ؊1 (P < 0.05 versus sham). Regarding the regional blood volume, a mean value of 11.8 ؎ 0.8 vol % was determined for healthy murine myocardium under anesthesia with Propofol (N ‫؍‬ 4, HR 233 ؎ 17 bpm). In total, the presented techniques provide noninvasive in vivo assessment of the perfusion and the regional blood volume in the murine myocardium for the first time and seem to be promising tools for the characterization of mouse models in cardiovascular research. Over the past decade, the mouse animal model has become an essential part of medical basic research. This is due to the high degree of similarity between the mouse and the human genomes of about 97% (1) and the resulting high relevance of mouse animal studies for human basic research. Regarding cardiovascular research, magnetic resonance imaging (MRI) provides noninvasive and accurate assessment of cardiac structure and function (2). Since the viability and the capability of the myocardium are strongly influenced by its microcirculation, a full characterization of the myocardium requires a quantification of parameters such as the perfusion and the intracapillary or regional blood volume (RBV). In particular, perfusion is of paramount importance as a physiologic parameter, since it strongly determines the function of organs and the severity of many diseases.Heart diseases involving ventricular dysfunction and hypertrophy show significant alterations of the myocardial perfusion and transgenic mouse models may be well suited to elucidate the underlying fundamental mechanisms.For the assessment of cardiac perfusion in mice, only a few methods have been presented to date. One possible approach is the quantification of the coronary flow in the isolated mouse heart by ultrasonic flow probes (3). The injection of labeled microsphe...

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Contrast‐enhanced first pass myocardial perfusion imaging: Correlation between myocardial blood flow in dogs at rest and during hyperemia

Cited by 332 publications

References 26 publications

Early Contrast-Enhanced MRI Predicts Late Functional Recovery After Reperfused Myocardial Infarction

Early Contrast-Enhanced MRI Predicts Late Functional Recovery After Reperfused Myocardial Infarction

Magnetic Resonance Perfusion Measurements for the Noninvasive Detection of Coronary Artery Disease

In vivo assessment of absolute perfusion and intracapillary blood volume in the murine myocardium by spin labeling magnetic resonance imaging

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