Contrast-enhanced magnetic resonance cholangiography with Gd-BOPTA and Gd-EOB-DTPA in healthy subjects

Dahlström, Nils; Persson, Anders; Albiin, Nils; Smedby, Örjan; Brismar, Torkel B.

doi:10.1080/02841850701196922

Cited by 80 publications

(60 citation statements)

References 29 publications

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“…Recently, heavily T2-weighted MR cholangiography has been proven to be an accurate modality in diagnosis of acute cholecystitis (4,21). Heavily T2-weighted MR cholangiography detects the water content of bile within intra-and extrahepatic biliary ducts and gallbladder in multiple planes without contrast material but, this modality is sensitive to motion artifacts and is not always decisive (13). Despite their validated clinical utilities US, computed tomography, and heavily T2-weighted MR cholangiography cannot provide functional information, however, they can demonstrate changes secondary to inflammation within gallbladder and biliary system.…”

Section: Discussionmentioning

confidence: 99%

“…However, the biliary excretion rate (50%) is significantly more than that of Gd-BOPTA (26). Recently, Dahlström et al compared contrast-enhanced MR cholangiography scans obtained with Gd-BOPTA and Gd-EOB-DTPA in 10 healthy volunteers in a prospectively designed protocol for biliary enhancement dynamics and concluded that biliary enhancement begins earlier and persists longer with Gd-EOB-DTPA (13). There is no consensus reached on when to acquire contrast-enhanced MR cholangiography images after injection, because the clinical experience for Gd-BOPTA-enhanced MR cholangiography is limited.…”

Section: Discussionmentioning

confidence: 99%

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Initial experience on utility of gadobenate dimeglumine (Gd‐BOPTA) enhanced T1‐weighted MR cholangiography in diagnosis of acute cholecystitis

Akpınar

Türkbey

Karçaaltıncaba

et al. 2009

Magnetic Resonance Imaging

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PurposeTo investigate the feasibility of the use of gadobenate dimeglumine (also known as Gd‐BOPTA) ‐enhanced T1‐weighted MR cholangiography in diagnosis of acute cholecystitis.Materials and MethodsThis prospectively designed institutional review board‐approved HIPAA‐compliant study was done between January and November 2007. We included 11 consecutive patients (7 male, mean age 59 years) who presented to the emergency room with acute right upper quadrant pain and with equivocal physical examination and/or ultrasound findings. The control group included 15 patients who underwent liver MRI with Gd‐BOPTA. All patients underwent contrast‐enhanced (CE) MR cholangiography examinations. CE‐MR cholangiography was performed on a 1.5 Tesla magnet using 3D T1‐weighted high resolution isotrophic volume examination (THRIVE) obtained at the 90th min after intravenous injection of Gd‐BOPTA. Imaging features detected on CE‐MR cholangiography were correlated with operative and histopathologic findings.ResultsIn the control group, GD‐BOPTA was visualized within the gallbladder in all subjects. For the study group, gallstones were present in nine patients (n = 7 both in gallbladder and cystic duct, n = 1 only in gallbladder, n = 1 only in cystic duct) on MRCP. Hydropic gallbladder was detected in seven patients, significant wall thickening in seven patients, and pericholecystic free fluid in 6 patients. On delayed phase CE cholangiography, significant enhancement of gallbladder wall was seen in 10 patients, and contrast agent excretion into gallbladder was absent in all patients. Surgery was performed in 10 patients, and cholecystostomy was done in 1 patient. Surgery and histopathology findings were consistent with cholecystitis in all patients.ConclusionIn addition to anatomical assessment, Gd‐BOPTA‐enhanced MR cholangiography can provide functional evaluation similar to HIDA scintigraphy in diagnosing acute cholecystitis in patients with acute right upper quadrant pain and equivocal findings. J. Magn. Reson. Imaging 2009;30:578–585. © 2009 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Initial experience on utility of gadobenate dimeglumine (Gd‐BOPTA) enhanced T1‐weighted MR cholangiography in diagnosis of acute cholecystitis

Akpınar

Türkbey

Karçaaltıncaba

et al. 2009

Magnetic Resonance Imaging

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“…This allows a functional evaluation of the biliary system within 20 minutes after administration of the contrast agent in the patients with normal liver function (5,(17)(18)(19). In recent years, Dahlström et al (20) compared Gd-BOPTA and Gd-EOB-DTPA enhanced MRC images in terms of biliary tract enhancement in 10 healthy volunteers. In that study, it was emphasized that biliary tract enhancement started earlier and lasted longer with Gd-EOB-DTPA (20).…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, Dahlström et al (20) compared Gd-BOPTA and Gd-EOB-DTPA enhanced MRC images in terms of biliary tract enhancement in 10 healthy volunteers. In that study, it was emphasized that biliary tract enhancement started earlier and lasted longer with Gd-EOB-DTPA (20). The recommended dose of Gd-EOB-DTPA is 0.025 mmol/kg and is also ¼ of Gd-BOPTA (10).…”

Section: Discussionmentioning

confidence: 99%

The Impact of Gd-Eob-Dtpa-Enhanced MR Cholangiography in Biliary Diseases: Comparison with T2-Weighted MR Cholangiopancreatography

et al. 2016

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Background: Contrast enhanced magnetic resonance cholangiography is a novel technique and promising method in demonstrating biliary tree anatomy and evaluating biliary disorders. However, to date, there are a limited number of studies that have focused on the impact of this technique. Aims: We aimed to evaluate the additional role of contrast enhanced MR cholangiography (MRC) and compare contrast enhanced MRC with T2-weighted (w) magnetic resonance cholangiopancreatography (MRCP) in the diagnosis of biliary disorders. Study Design: Diagnostic accuracy study. Methods: The T2w-MRCP and contrast enhanced MRC sequences of 31 patients whose gold standard test results were available were scored visually for the existence of pathological findings with regard to any of the biliary diseases. Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) was used as the contrast agent. The correlation values were determined according to the statistical analysis made from those scores and the sensitivity, specificity and accuracy values of each sequence were detected as well. Results:We detected that the correlation values with gold standard methods of contrast enhanced MRC sequences were significantly higher than the ones of T2w-MRCP sequences. The correlation ratios of T2w-MRCP sequences were between 26 and 34%, while those for contrast enhanced MRC sequences were between 81 and 83% for the first reader and the correlation ratios of T2w-MRCP sequences were between 10 and 61%, whereas those of contrast enhanced MRC were between 79 and 81% for the second reader The mean sensitivity, specificity and accuracy values of T2w-MRCP sequences were 14.3-42.5%, 85-89.2% and 59.3-72.5%, respectively, while the mean sensitivity, specificity and accuracy values of contrast enhanced MRC sequences were 100%, 86.7% and 93.2-93.3%, respectively. Conclusion: We suggest that obtaining of contrast enhanced MRC sequences in addition to the T2w-MRCP can be useful in the diagnosis of many diseases in relation with biliary tree.

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“…Gd-EOB-DTPA is eliminated by biliary and urinary excretion; in healthy volunteers, the agent was completely eliminated in almost equal amounts in urine (43.1-53.2z) and feces (41.6-51.2z). 2 Gd-EOB-DTPA has been reported as a biliary contrast agent with T1-weighted MR imaging, [3][4][5][6][7]12,13 and its biliary excretion can also be used this way.…”

Section: Discussionmentioning

confidence: 99%

Effects of Gadolinium-ethoxybenzyl-diethylenetriamine Pentaacetic Acid on T2-weighted MRCP

Nakamura

Saito

et al. 2009

magn reson med sci

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Purpose: Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is a recently developed liver-speciˆc contrast agent for magnetic resonance (MR) imaging that is excreted equally via the kidneys and the biliary system. To our knowledge, its eŠects on T 2 -weighted MR cholangiopancreatography (MRCP) images have not been explored. Acquisition of the hepatobiliary phase is recommended 20 min after administration of Gd-EOB-DTPA. Examination time cannot be extended if the contrast does not take eŠect on T 2 -weighted MRCP within 20 min after administration.We attempted to assess the change in signal of T 2 -weighted MRCP by excretion of Gd-EOB-DTPA.Methods: Between March and July 2008, 40 patients (15 women, 25 men; mean age 70.8 years) were examined with abdominal MR imaging. T 2 -weighted MRCP was performed before and 10 and 20 min after administration of Gd-EOB-DTPA. We analyzed signal intensity of the bile duct, gallbladder, cystic duct, and pancreatic duct on MRCP for changes in intensity.Results: T 2 -weighted MRCP 20 min after contrast administration showed loss of signal of the bile duct (intrahepatic bile duct in all cases, upper extrahepatic duct in 36 [90z], middle extrahepatic duct in 33 [85z], and lower extrahepatic duct in 26 [67z]), the gallbladder in 23 cases (72z), and the cystic duct in 25 (64z). This signal change increased with time. We observed no change in signal of the pancreatic duct.Conclusion: T 2 -weighted MRCP sequences should not be obtained after administration of Gd-EOB-DTPA because this contrast agent decreases signal intensity of the biliary structure on these images.

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Contrast-enhanced magnetic resonance cholangiography with Gd-BOPTA and Gd-EOB-DTPA in healthy subjects

Cited by 80 publications

References 29 publications

Initial experience on utility of gadobenate dimeglumine (Gd‐BOPTA) enhanced T1‐weighted MR cholangiography in diagnosis of acute cholecystitis

Initial experience on utility of gadobenate dimeglumine (Gd‐BOPTA) enhanced T1‐weighted MR cholangiography in diagnosis of acute cholecystitis

The Impact of Gd-Eob-Dtpa-Enhanced MR Cholangiography in Biliary Diseases: Comparison with T2-Weighted MR Cholangiopancreatography

Effects of Gadolinium-ethoxybenzyl-diethylenetriamine Pentaacetic Acid on T2-weighted MRCP

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