Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion.

Berthezène, Yves; Vexler, Vladimir; Clémеnt, Olivier; Mühler, Andreas; Moseley, Michael E.; Brasch, R. C.

doi:10.1148/radiology.183.3.1584916

Cited by 107 publications

(70 citation statements)

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“…In contrast, MRI does not rely on ionizing radiation and permits ventilation imaging of the lungs with high spatial and temporal resolution using paramagnetic contrast agents. However, MRI of the lung parenchyma is problematic because of relatively low number of hydrogen protons, cardiac and respiratory motion, and susceptibility effects induced by multiple air and tissue interfaces (10,26,27). These problems can be overcome by the use of pulse sequences with a very short echo time (TE), breath hold imaging, and cardiac gating.…”

Section: Discussionmentioning

confidence: 99%

Aerosol Delivery in Ventilated Newborn Pigs: An MRI Evaluation

et al. 2008

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Pulmonary deposition of inhaled drugs in ventilated neonates has not been studied in vivo. The objective of this study was to evaluate pulmonary delivery of gadopentetate dimeglumine (Gd-DTPA) following nebulization in ventilated piglets using magnetic resonance imaging. Seven ventilated piglets (5 Ϯ 2 d old, weight 1.8 Ϯ 0.5 kg) were scanned in the Bruker/Siemens 4T magnetic resonance scanner using T1 weighted spin-echo sequence. Aerosols of Gd-DTPA were generated continuously using the MiniHeart jet nebulizer. Breath-hold coronal images were obtained before and every 10 min during aerosolized Gd-DTPA for 90 min. Signal intensity (SI) changes over the lungs, kidneys, liver, skeletal muscle, and heart were evaluated. A significant increase in SI was observed in the lungs, kidney, and liver at 10, 20, and 40 min respectively after start of aerosol. At the end of 90 min, the SI increased by 95%, 101%, and 426% over the right lung, left lung, and kidney, respectively. A much smaller increase in SI was observed over the liver. In conclusion, we have demonstrated effective pulmonary aerosol delivery within 10 min of contrast nebulization in ventilated piglets. Contrast visualization in the kidneys within 20 min of aerosol initiation reflects alveolar absorption, glomerular filtration and renal concentration. (Pediatr Res 64: 159-164, 2008)

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Section: Discussionmentioning

confidence: 99%

Aerosol Delivery in Ventilated Newborn Pigs: An MRI Evaluation

et al. 2008

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“…Different MR strategies for V/Q scanning have been implemented using magnetic resonance imaging. Berthezene et al (9) propose the use of aerosolized gadopentetate dimeglumine to image regional lung ventilation, and intravenously administered gadopentetate dimeglumine to assess regional lung perfusion. However, aerosolized gadopentetate dimeglumine is not yet approved for clinical use.…”

Section: Discussionmentioning

confidence: 99%

MR ventilation‐perfusion imaging of human lung using oxygen‐enhanced and arterial spin labeling techniques

Bankier

Prasad

et al. 2001

Magnetic Resonance Imaging

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Magnetic resonance ventilation-perfusion (V/Q) imaging has been demonstrated using oxygen and arterial spin labeling techniques. Inhaled oxygen is used as a paramagnetic contrast agent in ventilation imaging using a multiple inversion recovery (MIR) approach. Pulmonary perfusion imaging is conducted using a flow-sensitive alternating inversion recovery with an extra radiofrequency pulse (FAIRER) technique. A half Fourier single-short turbo spin echo (HASTE) sequence is used for data acquisition in both techniques. V/Q imaging was performed in ten of the twenty volunteers, while either ventilation or perfusion was imaged in the other ten. This V/Q imaging scheme is completely noninvasive, does not involve ionized radiation, and shows promising potential for clinical use in the diagnosis of lung diseases such as pulmonary embolism. J. Magn. Reson. Imaging 2001;14: 574 -579.

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“…Other proposed schemes use inhaled 13 N and PET, or a radiodense gas (typically stable Xe) and standard X-ray, computed tomograph, or synchrotron radiation (7). MR-based techniques include MRI of aerosolized contrast agents such as gadolinium-diethylenetriamine pentaacetic acid (8,33,47,64,81,82) and oxygen-enhanced MRI as a measure of ventilation (6, 20, 44, 57, 69 -71, 93).…”

Section: Regional Ventilationmentioning

confidence: 99%

Advances in magnetic resonance imaging of lung physiology

Hopkins

Levin

Emami

et al. 2007

Journal of Applied Physiology

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This review presents an overview of some recent magnetic resonance imaging (MRI) techniques for measuring aspects of local physiology in the lung. MRI is noninvasive, relatively high resolution, and does not expose subjects to ionizing radiation. Conventional MRI of the lung suffers from low signal intensity caused by the low proton density and the large degree of microscopic field inhomogeneity that degrades the magnetic resonance signal and interferes with image acquisition. However, in recent years, there have been rapid advances in both hardware and software design, allowing these difficulties to be minimized. This review focuses on some newer techniques that measure regional perfusion, ventilation, gas diffusion, ventilation-to-perfusion ratio, partial pressure of oxygen, and lung water. These techniques include contrastenhanced and arterial spin-labeling techniques for measuring perfusion, hyperpolarized gas techniques for measuring regional ventilation, and apparent diffusion coefficient and multiecho and gradient echo techniques for measuring proton density and lung water. Some of the major advantages and disadvantages of each technique are discussed. In addition, some of the physiological issues associated with making measurements are discussed, along with strategies for understanding large and complex data sets.hyperpolarized helium-3 magnetic resonance imaging; regional ventilation; regional perfusion; apparent diffusion coefficient; ventilation-perfusion ratio; regional lung water MANY PULMONARY DISORDERS ARE characterized by either an inability to supply fresh air to the exchange membrane (ventilation), an inability to supply blood to the membrane (perfusion), or an abnormality of the membrane itself, which hinders efficient gas diffusion. As one of the primary and most accessible activities of the lung, measurement of ventilation and lung volumes has been the focus of most pulmonary function tests, and spirometry is performed regularly to assess pulmonary integrity. Despite their usefulness, however, these global measures do not ultimately allow adequate characterization of disease heterogeneity; thus sensitivity to early and mild disease is lost, and the clinically relevant information for disease diagnosis and classification, as well as surgical planning, is incomplete. Developments in new imaging technologies in the past few decades have opened up new possibilities in acquiring regional information about the lung function and structure, with promise to address many of the intrinsic limitations of global measurements.Shortly after the first axial X-ray computed tomograph became available in 1971, techniques were described that applied magnetic field gradients in three dimensions to create nuclear magnetic resonance (MR) images. The first images of two tubes of water were published in March 1973 (52). Since conventional MR imaging (MRI) exploits properties of protons in magnetic fields to produce images, the lung has historically presented problems, not only because it contains mostly air, and the...

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Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion.

Cited by 107 publications

References 0 publications

Aerosol Delivery in Ventilated Newborn Pigs: An MRI Evaluation

Aerosol Delivery in Ventilated Newborn Pigs: An MRI Evaluation

MR ventilation‐perfusion imaging of human lung using oxygen‐enhanced and arterial spin labeling techniques

Advances in magnetic resonance imaging of lung physiology

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