Contrast‐enhanced ¹⁸F‐FDG‐PET/CT for the assessment of necrotic lymph node metastases

Abstract

Contrast-enhanced CT and contrast-enhanced ¹⁸F-FDG-PET/CT perform equally and better than non-enhanced ¹⁸F-FDG-PET/CT in detecting CLNM in tonsillar SCC. Therefore, in patients scheduled for ¹⁸F-FDG-PET/CT, we strongly suggest performing a contrast-enhanced ¹⁸F-FDG-PET/CT, which is not routine in most centers.

PET/CT Imaging and Human Papilloma Virus–Positive Oropharyngeal Squamous Cell Cancer: Evolving Clinical Imaging Paradigm

“…2) (41). In a retrospective study by Haerle et al (41), 34 patients with tonsillar SCC underwent pretreatment contrast-enhanced 18 F-FDG PET/CT followed by neck dissection as a standard of reference. The enhanced CT part, 18 F-FDG PET part, nonenhanced 18 F-FDG PET/CT part, and enhanced 18 F-FDG PET/CT part were assessed separately.…”

Role of fluorine-18 fluorodeoxyglucose PET/CT in head and neck oncology: the point of view of the radiation oncologist

“…46,47 Recently, there have been several reports of the possible superiority of PET/CE-CT over standard PET/CT in different clinical settings, including better local 48 and nodal analysis. 49 Other studies, 50,51 confirmed the high accuracy of nodal staging by PET/CT, in particular, if CE-CT is used during PET protocol.…”

Combined PET/CT-perfusion in patients with head and neck cancers

“…An interesting aspect might be that metastatic lymph nodes in our studyhadahighBF,alowBVandafastMTT.Thismightbepartly attributed to HPV-positive lymph nodes. Those nodes are generally large, but do contain a large amount of cystic/necrotic material and thus the SUV can be very low [27]. We did not evaluate PS because we used too short a protocol to measure stable PS values.…”