Contrast-enhanced ultrasonography for differential diagnosis of adnexal masses

Shentu, Weihui; Zhang, Yin; Gu, Jing; Wang, Fa; Zhao, Wei; Liu, Chunmei; Lin, Zimei; Wang, Yao; Liu, Chen; Chen, Yun-Yu; Fan, Qingyu; Wang, Hongying

doi:10.3389/fonc.2022.968759

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…In line with the findings of earlier research ( 22 ), the PI, AT d , and AS values of the lesion in this study were all significantly higher in the malignant lesions than in benign lesions. Additionally, the myometrium was used as a reference in this study.…”

Section: Discussionsupporting

confidence: 93%

Clinical value of quantitative analysis of contrast-enhanced ultrasonography in the differential diagnosis of benign and malignant pelvic tumors

Fan,

Zhang,

Wang

et al. 2023

Quant Imaging Med Surg

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Background Cervical cancer, endometrial cancer, and ovarian cancer are among the top 10 most common cancers in women, with ovarian cancer in particular being considered a “silent killer”. Therefore, early detection, diagnosis, and treatment constitute important means of care for women’s health. This study investigated the clinical value of the quantitative analysis of contrast-enhanced ultrasonography (CEUS) in the differential diagnosis of benign and malignant pelvic tumors. Methods CEUS was performed on 151 patients with pelvic masses. Subsequently, a qualitative diagnosis was completed using the image enhancement features and tumor parameters. A multiparametric analysis of CEUS images was performed, which included the following parameters: arrival time (AT), time to peak (TTP), peak intensity (PI), and ascent slope (AS). In addition, the qualitative diagnostic efficiency of CEUS was assessed in a multiparametric analysis, and the results were compared with pathological findings. Results The patients in the malignant group were older (P=0.001) and had larger lesion PI values (P<0.01) than those in the benign group. The PI difference (PI d ) and the AS difference (AS d ) showed statistical differences (P<0.01) between the myometrium and lesion tissues in the same patient. Moreover, the PI d and AS d showed the largest receiver operating characteristic (ROC) curve and area under the ROC curve (AUC), with sensitivities of 90.9% and 91.7% and specificities of 86.4% and 72.5%, respectively. Conclusions The quantitative analysis of CEUS provides a new, simpler, and more accurate method for the differential diagnosis of benign and malignant pelvic masses in clinical practice. The sensitivities and specificities of PId and ASd were higher compared to other parameters from the same patient.

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Section: Discussionsupporting

confidence: 93%

Clinical value of quantitative analysis of contrast-enhanced ultrasonography in the differential diagnosis of benign and malignant pelvic tumors

Fan,

Zhang,

Wang

et al. 2023

Quant Imaging Med Surg

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“…In recent years, contrast-enhanced ultrasonography (CEUS) has been developing and advancing, and is able to better observe the characteristics of blood vessels in adnexal masses 8 . Compared with color Doppler ultrasound, CEUS can show the blood ow of microvessels in adnexal masses in real time, dynamically, and clearly, and can help doctors more accurately assess adnexal masses that are di cult to identify as benign or malignant by traditional ultrasound 9 . The aim of this study was to investigate the ability of the IOTA LR2 and IOTA LR2 combined with CEUS to assess the benign or malignant nature of adnexal masses in patients and to validate it on the basis of postoperative pathological ndings to explore the clinical value of the IOTA LR2 and IOTA LR2 combined with ultrasonography in predicting the nature of adnexal masses.…”

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confidence: 99%

Clinical Value of IOTA LR2 and IOTA LR2 Combined with CEUS in Assessing the Nature of Adnexal Masses

Yan,

Han,

Zhang

et al. 2024

Preprint

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Objective To investigate the preoperative assessment of adnexal tumor benignity and malignancy using the International Ovarian Tumour Analysis (IOTA) logistic regression model 2 (LR2) and LR2 combined with contrast-enhanced ultrasound (CEUS). Clinical application of LR2 and CEUS in the preoperative assessment of adnexal tumors was evaluated. Methods One hundred and ninety-eight adnexal tumors were selected, and their nature was evaluated preoperatively according to IOTA LR2 and LR2 combined with CEUS. Pathological and long-term follow-up results were used as the gold standard for comparison. Results For the diagnostic efficacy of LR2 for identifying the nature of ovarian masses, the AUC was 0.90 (0.85–0.94). For the diagnostic efficacy of LR2 combined with CEUS in identifying the benign and malignant nature of ovarian tumors, the AUC was 0.92 (0.88–0.97). Conclusion The IOTA LR2 model has high sensitivity but low specificity. Its diagnostic specificity can be significantly improved by combining it with CEUS. Therefore, LR2 combined with CEUS has high clinical value and can help ultrasonographers determine the benign or malignant nature of adnexal tumors.

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Diagnostic Value of Contrast‐Enhanced Ultrasound in Benign and Malignant Adnexal Masses

Zhang,

Han

2024

J of Ultrasound Medicine

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In the diagnosis of gynecological tumors, determining the benign or malignant nature of adnexal masses is a crucial and complex issue. Contrast‐enhanced ultrasound (CEUS) is a relatively novel and increasingly used diagnostic method. Therefore, this study evaluated the diagnostic value of CEUS in differentiating benign and malignant adnexal masses through meta‐analysis and systematic review. We systematically searched PubMed, Embase, Web of Science, and the Cochrane Library for studies published up to April 2024 regarding the use of CEUS in diagnosing benign and malignant adnexal masses. STATA 14.0 software was used for data analysis, pooling the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio (DOR) of eligible studies. After initial screening, 305 studies were identified, 13 of which met the inclusion criteria and were analyzed in this meta‐analysis. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and DOR of CEUS for the diagnosis of benign and malignant adnexal masses were 0.92 (95% confidence interval [CI]: 0.88–0.95), 0.88 (95% CI: 0.82–0.93), 8.00 (95% CI: 5.00–12.90), 0.09 (95% CI: 0.06–0.14), and 91.00 (95% CI: 45.00–185.00), respectively. The area under the summary receiver operating characteristic curve (AUC) was 0.95 (95% CI: 0.93–0.97). CEUS is a noninvasive, nonradiative imaging modality with high accuracy and reliability in the diagnosis of benign and malignant adnexal masses. To provide an effective adjunct tool in the clinic, future studies can further explore the specific application value of CEUS and its performance in different populations.

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Contrast-enhanced ultrasonography for differential diagnosis of adnexal masses

Cited by 4 publications

References 34 publications

Clinical value of quantitative analysis of contrast-enhanced ultrasonography in the differential diagnosis of benign and malignant pelvic tumors

Clinical value of quantitative analysis of contrast-enhanced ultrasonography in the differential diagnosis of benign and malignant pelvic tumors

Clinical Value of IOTA LR2 and IOTA LR2 Combined with CEUS in Assessing the Nature of Adnexal Masses

Diagnostic Value of Contrast‐Enhanced Ultrasound in Benign and Malignant Adnexal Masses

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