Contrast-Enhanced Ultrasound Characteristics of Breast Cancer: Correlation with Prognostic Factors

Cao, Xiaoli; Bao, Wei; Zhu, Shuchai; Wang, Lihong; Sun, Ming‐Hui; Wang, Li; Men, Yan-Ming; Xue, Jie

doi:10.1016/j.ultrasmedbio.2013.08.014

Cited by 45 publications

(37 citation statements)

References 18 publications

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“…Contrast‐enhanced ultrasonography, which enables the noninvasive evaluation of tissue perfusion, identified complex carcinomas with moderate accuracy, due to the shorter periods of contrast wash‐in and peak enhancement times observed in this type of tumor. These findings corroborated previous reports, which correlated lower perfusion times with more severe types of breast tumors in women . On the other hand, an increase in perfusion times (wash‐in, peak enhancement, and washout times) enabled the detection of grade II and III carcinomas, with moderate accuracy.…”

Section: Discussionsupporting

confidence: 91%

“…On the other hand, an increase in perfusion times (wash‐in, peak enhancement, and washout times) enabled the detection of grade II and III carcinomas, with moderate accuracy. These results contradicted reports on breast cancer in women . However, it is possible that tumors with complex behaviors expand differently in the female dog due to the anatomical characteristics and larger mammary glands when compared to women .…”

Section: Discussioncontrasting

confidence: 90%

“…These findings corroborated previous reports, which correlated lower perfusion times with more severe types of breast tumors in women. 19,20 On the other hand, an increase in perfusion times (wash-in, peak enhancement, and washout times) enabled the detection of grade II and III carcinomas, with moderate accuracy. These results contradicted reports on breast cancer in women.…”

Section: Discussionmentioning

confidence: 99%

“…These results contradicted reports on breast cancer in women. 19,20 However, it is possible that tumors with complex behaviors expand differently in the female dog due to the anatomical characteristics and larger mammary glands when compared to women. 8,21 Furthermore, this different configuration could possibly lead to the slower perfusion observed in high-grade carcinomas.…”

Section: Discussionmentioning

confidence: 99%

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Accuracy of four ultrasonography techniques in predicting histopathological classification of canine mammary carcinomas

Feliciano

Ramirez

Maronezi

et al. 2018

Vet Radiology Ultrasound

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Due to the importance of presurgical, noninvasive, and accurate diagnostic tools in mammary carcinoma characterization, this prospective secondary observational cohort study was designed to evaluate and compare the diagnostic accuracy of B-mode, Doppler, contrast enhancement ultrasonography, or acoustic radiation force impulse-elastography in identifying mammary carcinomas types with high degree of malignancy. A total of 246 mammary carcinomas from 141 female dogs were analyzed using B-mode, Doppler, contrast enhancement ultrasonography, and acoustic radiation force impulse ultrasonography prior to their histopathological classification according to types (simple, complex, or special) and grade (I, II, or III). Qualitative and quantitative variables were compared between carcinoma types and grades by Fisher's or analysis of variance. Diagnostic performance was estimated by receiver-operating characteristic analysis, using histopathological classification as a reference. Deformability (acoustic radiation force impulse) had a diagnostic specificity of 100% and sensitivity of 12% in identifying special carcinomas. A width:length ratio greater than 0.53 can be suggestive of special carcinoma, with 80% sensitivity and 76% specificity. Contrast wash-in and peak enhancement times lower than 7.5 and 13.5 s, respectively, were indicative of complex carcinoma at 62% sensitivity and 60% specificity. Contrast wash-in, peak enhancement, and wash-out times greater than 6.5, 12.5, and 64.5 s, respectively; were indicative of grade II and III carcinoma at 68% sensitivity and 62% specificity. In conclusion, B-mode ultrasonography, contrast enhancement ultrasonography, and acoustic radiation force impulse-elastography enabled the identification of some of the characteristics of high-grade mammary carcinoma types and grades in female dogs with limited accuracy. The findings from this study may contribute to oncology research and clinical management canine patients.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Accuracy of four ultrasonography techniques in predicting histopathological classification of canine mammary carcinomas

Feliciano

Ramirez

Maronezi

et al. 2018

Vet Radiology Ultrasound

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“…Masumoto and colleagues found that perfusion parameters on CEUS were significantly associated with ER, Her-2, and Ki-67 status [95]. This result is consistent with other studies [96,97]. CEUS also achieved high accuracy in predicting the heterogeneity of the response of breast cancer to neoadjuvant chemotherapy [98,99].…”

Section: Ultrasoundsupporting

confidence: 81%

Progress in the clinical detection of heterogeneity in breast cancer

et al. 2016

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Breast cancer is currently the most common form of cancer and the second‐leading cause of death from cancer in women. Though considerable progress has been made in the treatment of breast cancer, the heterogeneity of tumors (both inter‐ and intratumor) remains a considerable diagnostic and prognostic challenge. From clinical observation to genetic mutations, the history of understanding the heterogeneity of breast cancer is lengthy and detailed. Effectively detecting heterogeneity in breast cancer is important during treatment. Various methods of depicting this heterogeneity are now available and include genetic, pathologic, and imaging analysis. These methods allow characterization of the heterogeneity of breast cancer on a genetic level, providing greater insight during the process of establishing an effective therapeutic plan. This study reviews how the understanding of tumor heterogeneity in breast cancer evolved, and further summarizes recent advances in the detection and monitoring of this heterogeneity in patients with breast cancer.

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