Contrast-enhanced ultrasound findings in soft-tissue lesions: preliminary results

Stramare, Roberto; Gazzola, Maria Vittoria; Coran, Alessandro; Sommavilla, Marco; Beltrame, Valeria; Gerardi, Marco; Scattolin, G; Faccinetto, Alex; Rastrelli, Marco; Grisan, Enrico; Montesco, Maria Cristina; Róssi, Carlo; Rubaltelli, Léopoldo

doi:10.1007/s40477-013-0005-1

Cited by 14 publications

(10 citation statements)

References 6 publications

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“…The necrotic central portion of the tumor showed no enhancement. Our quantitative analysis results were similar to the findings of Stramare et al, 14 in that the viable peripheral soft tissue sarcomas showed early enhancement and a rapid time to peak. The patient had a limb‐sparing complete resection of the tumor and remained without disease after almost 2 years of follow‐up.…”

Section: Discussionsupporting

confidence: 91%

“…Stramare et al 14 evaluated 14 soft tissue lesions by contrast‐enhanced sonography, including 7 malignant (1 metastasis, 5 soft tissue sarcomas, and 1 lymphoma) and 7 benign (3 schwannomas, 1 angioleiomyoma, and 3 lipomas) tumors. They concluded that in malignant lesions, enhancement began earlier, and the time to peak was reached earlier, than in benign lesions.…”

Section: Discussionmentioning

confidence: 99%

“…They also found that malignant lesions and schwannomas had very similar kinetics of contrast accumulation. The authors did not detail the morphologic patterns of contrast enhancement they observed, beyond a dichotomous classification of homogeneous or heterogeneous 14 …”

Section: Discussionmentioning

confidence: 99%

“…The authors did not detail the morphologic patterns of contrast enhancement they observed, beyond a dichotomous classification of homogeneous or heterogeneous. 14 Loizides et al 15 performed contrast-enhanced sonography on 54 patients with musculoskeletal masses, followed by ultrasound-guided biopsy. The final pathologic diagnoses were greatly varied, but 50% (27) of the lesions were malignant, including 13 soft tissue sarcomas.…”

Section: Discussionmentioning

confidence: 99%

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Contrast‐Enhanced Sonography for Monitoring Neoadjuvant Chemotherapy in Soft Tissue Sarcomas

Gulati

Desai

et al. 2015

J of Ultrasound Medicine

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Neoadjuvant chemotherapy is a mainstay in treating soft tissue sarcomas. Soft tissue sarcomas can show an increase in size and central necrosis, with a decrease in the viable tumor, as an initial response to neoadjuvant chemotherapy. Thus, the maximum tumor diameter may not reliably assess the response to this therapy. Contrast-enhanced sonography may address this limitation. We evaluated 4 patients with soft tissue sarcomas by contrast-enhanced sonography, performed concomitantly with conventional imaging (computed tomography, magnetic resonance imaging, or positron emission tomography). Quantitative analysis was also performed on 1 sarcoma. A viable, enhancing tumor versus tumor necrosis was nearly identical on contrast-enhanced sonography and conventional imaging. Preliminary results demonstrate potential for contrast-enhanced sonographic monitoring of soft tissue sarcomas during neoadjuvant chemotherapy.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Contrast‐Enhanced Sonography for Monitoring Neoadjuvant Chemotherapy in Soft Tissue Sarcomas

Gulati

Desai

et al. 2015

J of Ultrasound Medicine

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“…2). Although potentially a very useful imaging tool [15], CEUS is still not widely used in clinical practice, and few reports have discussed its use in the evaluation of STT. The purposes of this pilot prospective longitudinal study were: evaluating the correlation between the results of histological examinations obtained by the simple unenhanced ultrasonography guidance and those obtained by CEUS guidance; comparing these results with the reference sample given from histopathological examination of the resected surgical mass.…”

Section: Introductionmentioning

confidence: 99%

Core needle biopsy of soft tissue tumors, CEUS vs US guided: a pilot study

et al. 2015

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Purpose The purpose of this study was to evaluate the usefulness of contrast-enhanced ultrasonography (CEUS) in the bioptic sampling of soft tissue tumors (STT) compared with unenhanced ultrasonography alone. Methods This is a prospective longitudinal study of 40 patients subjected to ultrasonography (US)-guided core needle biopsy (CNB) to characterize a suspected STT. Three series of bioptic samplings were carried out on each patient, respectively using unenhanced US alone and CEUS in both the areas of the tumor enhanced or not by the contrast medium. All bioptic samples underwent a histological evaluation and the results were analyzed by comparing the histology of the biopsy with the definitive diagnosis in 15 surgically excised samples. Results 27 (67.5 %) of the 40 patients completed the entire study procedure; in 19 cases (70.3 %) the three bioptic samplings gave unanimous results, also when compared to the surgical specimen; in seven cases (25.9 %) use of CEUS allowed to obtain additional or more accurate information about the mass in question, compared to simple US guidance without contrast; in one patient (3.7 %) sampling obtained using unenhanced ultrasonography guidance and in the areas enhanced by the contrast agent had precisely the same results of the surgical specimen. Conclusions CEUS, due to its ability to evaluate microvascular areas, has proven to be a promising method in guiding bioptic sampling of soft tissue tumor, directing the needle to the most significant areas of the tumor. Given the small number of patients evaluated in our study, to achieve statistically significant results, it would be appropriate to obtain a larger sample size, since the very first results seem to be encouraging and to justify the increase of the population.Keywords Contrast-enhanced ultrasonography Á Soft tissue tumors Á Core needle biopsy Riassunto Scopo Lo scopo di questo studio è stato quello di valutare l'utilità dell'ecografia conmdc (CEUS) rispetto alla ecografia tradizionale, nel prelievo bioptico dei tumori dei tessuti molli (STT). Metodi si tratta di uno studio longitudinale prospettico di 40 pazienti sottoposti ad ago-biopsia ecoguidata (US-CNB) per la caratterizzazione di un STT sospetto. Sono stati prelevati 3 campioni bioptici su ogni paziente, utilizzando ecografia b-mode e CEUS sia nelle aree del tumore non evidenziate dal mezzo di contrasto che in quelle dotate di contrast-enhancement. Tutti i campioni bioptici sono stati sottoposti a valutazione istologica e sono stati analizzati i risultati confrontando l'istologico della biopsia con i 15 campioni asportati chirurgicamente, con diagnosi definitiva. (2015( ) 18:335-342 DOI 10.1007 Risultati 27 (67,5%) dei 40 pazienti hanno completato l'intera procedura di studio; in 19 casi (70,3%) i tre campioni bioptici hanno dato risultati unanimi, anche rispetto al modello chirurgico; in 7 casi (25,9%) l'uso della CEUS ha permesso di ottenere informazioni supplementari, o più precise, circa la massa in questione, rispetto al semplice esame ecografico ...

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Ultrasound Application in Dermatologic Conditions

Wang

Darji

Jaramillo

et al. 2021

Ultrasound Fundamentals

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Contrast-enhanced ultrasound findings in soft-tissue lesions: preliminary results

Abstract: CEUS with analysis of contrast-enhancement kinetics is a relatively low-cost, minimally invasive imaging technique, which appears to be a potentially effective first-level method for identifying suspicious soft-tissue masses.

Cited by 14 publications

References 6 publications

Contrast‐Enhanced Sonography for Monitoring Neoadjuvant Chemotherapy in Soft Tissue Sarcomas

Contrast‐Enhanced Sonography for Monitoring Neoadjuvant Chemotherapy in Soft Tissue Sarcomas

Core needle biopsy of soft tissue tumors, CEUS vs US guided: a pilot study

Ultrasound Application in Dermatologic Conditions

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