Contrast-enhanced ultrasound-guided radiofrequency ablation in inconspicuous hepatocellular carcinoma on B-mode ultrasound

Kim, Eui Joo; Kim, Yun Soo; Shin, Seung Kak; Kwon, Oh Sang; Choi, Duck Joo; Kim, Ju Hyun

doi:10.5152/tjg.2017.17104

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…According to a previous study, about 83% of HCC, which were inconspicuous on fusion imaging with conventional grayscale US, were well visualized after CEUS. 152 After RFA of the hepatic tumor, it is essential to evaluate the treatment response. Although CECT has been used for this purpose, there are several limitations, including possible harmful effects of radiation and the iodinated contrast agent and an inaccurate assessment of the ablated margin.…”

Section: Literature Reviewmentioning

confidence: 99%

“…According to previous studies, the diagnostic accuracy of CEUS (93.8%-100%) for the evaluation of the RFA treatment response with either SonoVue or Sonazoid was comparable with CECT or CEMR. 152,153 The optimal time to assess the treatment response to RFA is 3 h after the procedure because the treated tumor margin is the most clearly perceived at this time. Uniform rim enhancement can be seen up to 30 days after RFA, and this rim enhancement should not be misdiagnosed as marginal tumor recurrence.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Efforts have also been made to evaluate the treatment response after TACE with CEUS. Although CEUS could detect residual intratumoral vascularity after TACE in previous studies, it is not feasible to use it as an evaluation tool after TACE because of the difficulty in evaluating multiple lesions, deeply located lesions, and poorly enhancing, or diffusely growing lesions [152][153][154] STRUCTURED REPORTING TEMPLATE AND MINIMUM DATA SET (TABLE 7) Literature Review…”

Section: Literature Reviewmentioning

confidence: 99%

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Joint Consensus Statement of the Indian National Association for Study of the Liver and Indian Radiological and Imaging Association for the Diagnosis and Imaging of Hepatocellular Carcinoma Incorporating Liver Imaging Reporting and Data System

Krishan¹,

Dhiman

Kalra

et al. 2019

Journal of Clinical and Experimental Hepatology

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Hepatocellular carcinoma (HCC) is the 6th most common cancer and the second most common cause of cancerrelated mortality worldwide. There are currently no universally accepted practice guidelines for the diagnosis of HCC on imaging owing to the regional differences in epidemiology, target population, diagnostic imaging modalities, and staging and transplant eligibility. Currently available regional and national guidelines include those from the American Association for the Study of Liver Disease (AASLD), the European Association for the Study of the Liver (EASL), the Asian Pacific Association for the Study of the Liver, the Japan Society of Hepatology, the Korean Liver Cancer Study Group, Hong Kong, and the National Comprehensive Cancer Network in the United States. India with its large population and a diverse health infrastructure faces challenges unique to its population in diagnosing HCC. Recently, American Association have introduced a Liver Imaging Reporting and Data System (LIRADS, version 2017, 2018) as an attempt to standardize the acquisition, interpretation, and reporting of liver lesions on imaging and hence improve the coherence between radiologists and clinicians and provide guidance for the management of HCC. The aim of the present consensus was to find a common ground in reporting and interpreting liver lesions pertaining to HCC on imaging keeping LIRADSv2018 in mind. (

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Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

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Joint Consensus Statement of the Indian National Association for Study of the Liver and Indian Radiological and Imaging Association for the Diagnosis and Imaging of Hepatocellular Carcinoma Incorporating Liver Imaging Reporting and Data System

Krishan¹,

Dhiman

Kalra

et al. 2019

Journal of Clinical and Experimental Hepatology

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“…Contrast-enhanced ultrasound (CEUS) could display the perfusion characteristics of liver lesions after bolus injection of ultrasound contrast agent [4]. Nowadays, CEUS has been applied in the diagnosis of HCC [5], guidance of liver-directed therapies [6], and postoperative assessment of HCC patients [7]. With the development of quantitative software, dynamic contrast-enhanced ultrasound (DCE-US) enables quantitative assessment of tumor perfusion through time-intensity curves [8].…”

Section: Introductionmentioning

confidence: 99%

Quantitative dynamic contrast-enhanced ultrasound may help predict the outcome of hepatocellular carcinoma after microwave ablation

Yang

Zhou

et al. 2018

International Journal of Hyperthermia

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Purpose: Previous studies have reported that parameters of dynamic contrast-enhanced ultrasound (DCE-US) could predict prognosis of hepatocellular carcinoma (HCC) patients after antiangiogenic therapies. In this study, we aimed to investigate the correlation of DCE-US parameters and the prognosis of HCC patients after microwave ablation (MWA). Materials and methods: Between June 2012 and January 2018, a total of 35 HCC patients who received MWA with a curative intent were enrolled. Pre-ablation DCE-US, liver biopsy, CD34 staining, and vascular endothelial growth factor (VEGF) staining were performed. DCE-US parameters were extracted from time-intensity curves using SonoLiver software. The correlation of DCE-US parameters with histopathology results and overall survival (OS) were investigated. Results: Quantitative analysis showed that IMAX, RT, TTP, and mTT of HCC were statistically different with that of reference liver parenchyma (all p ＜ .001). Microvessel density was shown to be positively correlated with IMAX and negatively correlated with TTP (r ¼ 0.755 and À0.647, both p ＜ .01). Additionally, positive correlations were observed between IMAX and VEGF expression (r ¼ 0.665, p ＜ .01). After a median follow-up of 22 months (range 6-64 months), local recurrence was detected in three patients. Largest diameter and TTP were shown to help predict OS in univariate and multivariate analyses. Conclusion: DCE-US parameter may help predict the outcome of HCC patients after MWA, though further study is still needed.

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Contrast-enhanced ultrasound to ultrasound fusion during microwave ablation: feasibility study in a perfused porcine liver model

2019

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Contrast-enhanced ultrasound-guided radiofrequency ablation in inconspicuous hepatocellular carcinoma on B-mode ultrasound

Cited by 5 publications

References 28 publications

Joint Consensus Statement of the Indian National Association for Study of the Liver and Indian Radiological and Imaging Association for the Diagnosis and Imaging of Hepatocellular Carcinoma Incorporating Liver Imaging Reporting and Data System

Joint Consensus Statement of the Indian National Association for Study of the Liver and Indian Radiological and Imaging Association for the Diagnosis and Imaging of Hepatocellular Carcinoma Incorporating Liver Imaging Reporting and Data System

Quantitative dynamic contrast-enhanced ultrasound may help predict the outcome of hepatocellular carcinoma after microwave ablation

Contrast-enhanced ultrasound to ultrasound fusion during microwave ablation: feasibility study in a perfused porcine liver model

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