Contrast-Enhanced Ultrasound Improves the Accuracy of the ACR TI-RADS in the Diagnosis of Thyroid Nodules Located in the Isthmus

Huang, Yunlin; Hong, Yanjun; Xu, Wen; Song, Kai; Huang, Pintong

doi:10.1055/a-1543-6033

Cited by 14 publications

(12 citation statements)

References 31 publications

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“…Micro calcifications and characteristics with a taller than wider form demonstrated good applicability, nevertheless. 19 Furthermore, Salmaslioglu et al, discovered that the presence of micro calcifications had a susceptibility of 91.3 % for malignancy in other research involving 549 individuals with nodules goiter. 12 The absence of flexibility had the best diagnostic performance in the current meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Ultrasound Features and Risk of Carcinoma: A Systematic Review and Meta-Analysis of Observational Studies

Bilal¹,

Shabbir²,

Lutfi³

et al. 2022

PJMHS

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Objective: This study was performed to evaluate how well thyroid nodules with nonspecific fine needle aspiration cytology and nonrandom nodules performed symptomatically for thyroid cancer. Study Design: Cross-sectional & observational study. Place and Duration: The study was conducted at Jinnah Hospital in July 2012. Methodology: We included individuals with thyroid nodules who had thyroidectomy after having their nodules assessed by the US were taken into consideration. We only took into account studies where surgical samples have been diagnosed by histology. For full-text evaluation, all of the chosen studies were accessed. Stata v11.0 software was used for all statistical analyses. Results: There were 52 observational studies totaling 12,816 nodules. 10 studies classified 1852 nodules that had uncertain cytology as a different group. With probabilities ranging from 2.15 to 3.77, all US characteristics of nonrandom nodules were substantially linked with cancer; micro calcifications, discontinuous edges, and a taller than broad form had significant particularities (Sp; 89.8 %, 85.3 %, and 98.1 %) and favorable probability ratios (LHR; 5.16, 4.19, 10.17). The one aspect with the better diagnostic efficacy was lack of flexibility (sensitivity 89.1 %, Sp 88.3 %, and positive LHR 8.19). Conclusions: Ultrasound characteristics are not an effective way to identify nodules that require fine needle aspiration cytology. To standardize elastography procedures and assess results, particularly in nodules with an undetermined cytology, more research is necessary. Keywords: Thyroid Ultrasound Features, Risk Of Carcinoma, Systematic Review, Meta-Analysis.

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Section: Discussionmentioning

confidence: 99%

Thyroid Ultrasound Features and Risk of Carcinoma: A Systematic Review and Meta-Analysis of Observational Studies

Bilal¹,

Shabbir²,

Lutfi³

et al. 2022

PJMHS

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“…Huang et al 77 68 The results showed that the combination of twodimensional ultrasound TI-RADS and SMI or CEU could improve the diagnostic accuracy, and the diagnostic efficiency of the three combined diagnosis was further improved.…”

Section: Multimodal Ultrasoundmentioning

confidence: 99%

“…Huang et al 77 evaluated the efficacy of CEU combined with ACR TI‐RADS in the diagnosis of benign and malignant thyroid nodules, and upregulated the malignant nodules suggested by CEU on the basis of the original ACR TI‐RADS classification, indicating that the benign nodules were downregulated. The results showed that the sensitivity and specificity of the combined diagnosis of malignant thyroid nodules were significantly improved, and it had suggestive significance in the diagnosis of thyroid nodules.…”

Section: Multimodal Ultrasoundmentioning

confidence: 99%

Multimodal ultrasound imaging: A method to improve the accuracy of diagnosing thyroid TI‐RADS 4 nodules

Han

Huang

Wang

et al. 2022

J of Clinical Ultrasound

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Thyroid nodule is a common and frequently occurring disease in the neck in recent years, and ultrasound has become the preferred imaging diagnosis method for thyroid nodule due to its advantages of noninvasive, nonradiation, real‐time, and repeatable. The thyroid imaging, reporting and data system (TI‐RADS) classification standard scores suspicious nodules that are difficult to determine benign and malignant as grade 4, and further pathological puncture is recommended clinically, which may lead to a large number of unnecessary biopsies and operations. Including conventional ultrasound, ACR TI‐RADS, shear wave elastography, super microvascular imaging, contrast enhanced ultrasound, “firefly,” artificial intelligence, and multimodal ultrasound imaging used in combination. In order to identify the most clinically significant malignant tumors when reducing invasive operations. This article reviews the application and research progress of multimodal ultrasound imaging in the diagnosis of TI‐RADS 4 thyroid nodules.

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“…CEUS can be applied non-invasively in real-time and continuously evaluate the perfusion of the microvessels in thyroid nodules under high frequency US ( 14 ). Studies have shown that the combination of the TI-RADS classification with CEUS significantly improves the diagnostic accuracy of thyroid nodules ( 15 , 16 ). However, CEUS enhancement features for thyroid nodules has still not been fully implemented with the TI-RADS system.…”

Section: Introductionmentioning

confidence: 99%

The use of modified TI-RADS using contrast-enhanced ultrasound features for classification purposes in the differential diagnosis of benign and malignant thyroid nodules: A prospective and multi-center study

Zhou

Chen²,

Zhou³

et al. 2023

Front. Endocrinol.

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ObjectivesTo evaluate the diagnostic efficacy of a modified thyroid imaging reporting and data system (TI-RADS) in combination with contrast-enhanced ultrasound (CEUS) for differentiating between benign and malignant thyroid nodules and to assess inter-observer concordance between different observers.MethodsThis study included 3353 patients who underwent thyroid ultrasound (US) and CEUS in ten multi-centers between September 2018 and March 2020. Based on a modified TI-RADS classification using the CEUS enhancement pattern of thyroid lesions, ten radiologists analyzed all US and CEUS examinations independently and assigned a TI-RADS category to each thyroid nodule. Pathology was the reference standard for determining the diagnostic performance (accuracy (ACC), sensitivity (SEN), specificity (SPN), positive predictive value (PPV), and negative predictive value (NPV)) of the modified TI-RADS for predicting malignant thyroid nodules. The risk of malignancy was stratified for each TI-RADS category-based on the total number of benign and malignant lesions in that category. ROC curve was used to determine the cut-off value and the area under the curve (AUC). Cohen’s Kappa statistic was applied to assess the inter-observer agreement of each sonological feature and TI-RADS category for thyroid nodules.ResultsThe calculated malignancy risk in the modified TI-RADS categories 5, 4b, 4a, 3 and 2 nodules was 95.4%, 86.0%, 12.0%, 4.1% and 0%, respectively. The malignancy risk for the five categories was in agreement with the suggested malignancy risk. The ROC curve showed that the AUC under the ROC curve was 0.936, and the cutoff value of the modified TI-RADS classification was >TI-RADS 4a, whose SEN, ACC, PPV, NPV and SPN were 93.6%, 91.9%, 90.4%, 93.7% and 88.5% respectively. The Kappa value for taller than wide, microcalcification, marked hypoechoic, solid composition, irregular margins and enhancement pattern of CEUS was 0.94, 0.93, 0.75, 0.89, 0.86 and 0.81, respectively. There was also good agreement between the observers with regards to the modified TI-RADS classification, the Kappa value was 0.80.ConclusionsThe actual risk of malignancy according to the modified TI-RADS concurred with the suggested risk of malignancy. Inter-observer agreement for the modified TI-RADS category was good, thus suggesting that this classification was very suitable for clinical application.

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Contrast-Enhanced Ultrasound Improves the Accuracy of the ACR TI-RADS in the Diagnosis of Thyroid Nodules Located in the Isthmus

Cited by 14 publications

References 31 publications

Thyroid Ultrasound Features and Risk of Carcinoma: A Systematic Review and Meta-Analysis of Observational Studies

Thyroid Ultrasound Features and Risk of Carcinoma: A Systematic Review and Meta-Analysis of Observational Studies

Multimodal ultrasound imaging: A method to improve the accuracy of diagnosing thyroid TI‐RADS 4 nodules

The use of modified TI-RADS using contrast-enhanced ultrasound features for classification purposes in the differential diagnosis of benign and malignant thyroid nodules: A prospective and multi-center study

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