Contrast-Enhanced Ultrasound in the Diagnosis of Patients Suspected of Having Active Crohn's Disease: Meta-analysis

Ma, Xuelei; Li, Yanyan; Jia, Hongjie; Zhang, Jing; Wang, Guoping; Liu, Xiaoxiao; Song, Yanlin

doi:10.1016/j.ultrasmedbio.2014.09.013

Cited by 36 publications

(20 citation statements)

References 48 publications

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“…With the remarkable improvements in sonographic equipment, TUS is increasingly used for the detection and evaluation of gastrointestinal lesions Liu et al 2014aLiu et al , 2014bMa et al 2015;Maconi et al 2009;Nylund et al 2013;Shen et al 2014;Shi et al 2012;Wei et al 2013). Moreover, TUS-OCCA has recently been suggested by some authors to be a valuable initial screening tool for gastric lesions in selected patients Liu et al 2014aLiu et al , 2014bLiu et al , 2015aLiu et al , 2015bShen et al 2014;Shi et al 2012;Wei et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Transabdominal Ultrasound with Oral Cellulose-Based Contrast Agent in the Detection and Surveillance of Gastric Ulcer

Liu

Guo

Wang

et al. 2017

Ultrasound in Medicine & Biology

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The aim of this study was to assess the role of transabdominal ultrasound with cellulose-based oral contrast agent (TUS-OCCA) in the detection and surveillance of gastric ulcer. The study was approved by the institutional review board at Shengjing Hospital of China Medical University. A total of 124 consecutive patients with benign gastric ulcer diagnosed by gastroscopy and biopsy were enrolled. Serial TUS-OCCA (approximately 1 exam every 2 wk) was performed to monitor the effects of treatment, and additional interventions were planned according to the results. TUS-OCCA detected gastric ulcer in 76% of patients (94 of 124). The detection rates for lesions of ≤5 mm, lesions of 5-10 mm, lesions of 10-15 mm and lesions >15 mm were 32% (10 of 31), 77% (27 of 35), 96% (25 of 26) and 100% (32 of 32), respectively. The detection rates for lesions located in the antrum, angle and body were 70%, 84% and 85%, respectively. Among 30 undetected lesions, which ranged 2-13 mm in size, 11 were at the antrum, 9 at the angle, 3 in the body, 6 at the cardia and 1 at the fundus. During the follow-up period, patients underwent a mean of 3.8 TUS-OCCA examinations (range 2-7), and ulcers were healed after 8 wk (range 2-12 wk) of standard therapy in 76 patients. Eighteen patients who did not show improvement after standard therapy underwent repeat gastroscopy with biopsy. Repeat biopsy was positive for gastric cancer in 4 of these: 2 of the remaining 14 were diagnosed with gastric cancer at gastrectomy, and 12 were diagnosed with chronic benign ulcer. These results indicate that serial TUS-OCCA can be used for close monitoring during routine treatment of gastric ulcers that are detectable by TUS-OCCA and that monitoring by TUS-OCCA can guide additional interventions. A non-invasive follow-up program based on TUS-OCCA can also help to detect gastric cancers that have been misdiagnosed as benign ulcers at the initial endoscopic biopsy.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Transabdominal Ultrasound with Oral Cellulose-Based Contrast Agent in the Detection and Surveillance of Gastric Ulcer

Liu

Guo

Wang

et al. 2017

Ultrasound in Medicine & Biology

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“…Recently, a meta-analysis, published in March 2015, which included a total of 8 articles and 428 CD patients, analysed CEUS performance and accuracy in the detection of active CD, using endoscopic and clinical indices as the reference standard: the CEUS sensitivity and specificity for active CD were 93 and 87%, respectively, the diagnostic odds ratio was 80 and the area under the curve was 0.96 [59].…”

Section: Ceusmentioning

confidence: 99%

SICUS and CEUS imaging in Crohn’s disease: an update

et al. 2017

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Endoscopy remains the main technique in the diagnosis and treatment of Crohn's disease (CD); nevertheless, the recent development of innovative and non-invasive imaging techniques has led to a new tool in the exploration of small bowel in CD patients. This paper reviews the available data on ultrasound imaging used for the evaluation of CD, highlighting the role of small intestine contrast-enhanced ultrasonography with the use of oral and intravenous contrast agents.Keywords Crohn's disease Á Contrast-enhanced ultrasound Á Small intestine contrast ultrasonography Sommario Nell'iter diagnostico e terapeutico della malattia di Crohn l'endoscopia rappresenta la principale metodica strumentale. Tuttavia, la recente introduzione di tecniche di imaging innovative e non invasive ha implementato lo studio dell'intestino nelle malattie infiammatorie croniche intestinali. La seguente revisione raccoglie i dati disponibili in letteratura relativi all'utilizzo dell'ecografia con mezzo di contrasto, sia orale (SICUS) sia endovenoso (CEUS), nella valutazione dei pazienti affetti da malattia di Crohn.

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“…However there are increasing reports describing the utility of qualitative evaluation of bowel wall vascularity patterns in CD using CEUS [80, 81], as well as software defined quantitative metrics from time-intensity curves such as time-to-peak, peak enhancement and area under the curve [82–85]. Promising data for evaluation of CD activity against an endoscopic reference have been reported [84, 86], as well as utility in stricture characterisation [87], detection of postoperative recurrence [88], and treatment response evaluation [89].…”

Section: Discussionmentioning

confidence: 99%

The first joint ESGAR/ ESPR consensus statement on the technical performance of cross-sectional small bowel and colonic imaging

et al. 2016

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ObjectivesTo develop guidelines describing a standardised approach to patient preparation and acquisition protocols for magnetic resonance imaging (MRI), computed tomography (CT) and ultrasound (US) of the small bowel and colon, with an emphasis on imaging inflammatory bowel disease.MethodsAn expert consensus committee of 13 members from the European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and European Society of Paediatric Radiology (ESPR) undertook a six-stage modified Delphi process, including a detailed literature review, to create a series of consensus statements concerning patient preparation, imaging hardware and image acquisition protocols.ResultsOne hundred and fifty-seven statements were scored for agreement by the panel of which 129 statements (82 %) achieved immediate consensus with a further 19 (12 %) achieving consensus after appropriate modification. Nine (6 %) statements were rejected as consensus could not be reached.ConclusionsThese expert consensus recommendations can be used to help guide cross-sectional radiological practice for imaging the small bowel and colon.Key points• Cross-sectional imaging is increasingly used to evaluate the bowel • Image quality is paramount to achieving high diagnostic accuracy • Guidelines concerning patient preparation and image acquisition protocols are provided

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Contrast-Enhanced Ultrasound in the Diagnosis of Patients Suspected of Having Active Crohn's Disease: Meta-analysis

Cited by 36 publications

References 48 publications

Evaluation of Transabdominal Ultrasound with Oral Cellulose-Based Contrast Agent in the Detection and Surveillance of Gastric Ulcer

Evaluation of Transabdominal Ultrasound with Oral Cellulose-Based Contrast Agent in the Detection and Surveillance of Gastric Ulcer

SICUS and CEUS imaging in Crohn’s disease: an update

The first joint ESGAR/ ESPR consensus statement on the technical performance of cross-sectional small bowel and colonic imaging

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