Contrast enhanced ultrasound in urothelial carcinoma of urinary bladder: An underutilized staging and grading modality

Gupta, Vijayant Govinda; Kumar, Santosh; Singh, Shrawan Kumar; Lal, Anupam; Kakkar, Nandita

doi:10.5173/ceju.2016.893

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…Type A curve is defined by rapid and high peak enhancement and fast wash-out time, correlating well with high grade UCC. Type B is defined by an early enhancement peak but slow plateau and very slow wash-out time, correlating well with low grade UCC [ 15 ]. In our study, CEUS with TIC of SCCB showed wash-in time of 10 s, TTP of 33 s, SI of 62.7% and wash-out time > 60 s. This is similar to the results of high grade UCC with high SI and slow wash-out time as reported by Drudi et al in 2014 [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasound of small cell carcinoma in urinary bladder: a case report and review of literature

et al. 2017

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BackgroundSmall cell carcinoma of the urinary bladder (SCCB) is a relatively rare malignant bladder tumor, and few reports have investigated the microvasculature of SCCB imaged using contrast-enhanced ultrasound (CEUS).Case presentationA 63-year-old female was admitted to our hospital after experiencing painless gross hematuria for one week. The gray-scale ultrasound (US) demonstrated a 4.8 × 3.4 × 3.6-cm3 hypoechoic mass in the apex of the urinary bladder with a wide base and an irregular surface; the mass did not move with changes in body position. Color Doppler flow imaging (CDFI) showed rich blood flow in the mass. CEUS with low mechanical index (MI) of 0.06 confirmed a highly enhanced 5.0 × 3.3 × 3.8 cm3 mass within the bladder at the apex wall. The time-intensity curves (TICs) showed a wash-in time of 10 s, a time to peak (TTP) of 33 s, a signal intensity (SI) of 62.7% and a wash-out time > 60 s. Finally, the transurethral resection of the bladder tumor (TURBT) was performed, and the pathological examination proved the diagnosis of SCCB.ConclusionCEUS can provide valuable information related to the rich microvasculature of SCCB, which may be helpful in its diagnosis.

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Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasound of small cell carcinoma in urinary bladder: a case report and review of literature

et al. 2017

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“…Two-Dimensional Ultrasonography (2D US) is a widely used and recommended method for evaluating hematuria and for staging, particularly in patients who have allergies to intravenous contrast agents and renal failure (Figure 1) [5, 17–21]. However, according to some publications 2D US is not recommended for the staging of BCa because it may not reveal the true local depth of its invasion [18–21]. Three-dimensional US provides BCa imaging in multiple planes, and may improve the accuracy of staging BCa [19].…”

Section: Introductionmentioning

confidence: 99%

“…CEUS is a new technique that uses microbubbles as a ultrasonographic contrast agent to determine the grade and stage of BCa [18]. The use of CEUS was investigated to predict T stage and grade of BCa prior to endoscopic resection in 110 patients suspected of BCa.…”

Section: Introductionmentioning

confidence: 99%

“…Results were compared with histology. CEUS had the T stage: Ta sensitivity of 75%; specificity of 95%, T1 sensitivity 65%; specificity 85% and muscle invasion sensitivity 90% with the specificity of 92% [18]. CEUS differentiated high grade (n=110) and low grade (n=82) urothelial BCa with 86% sensitivity, 90% specificity, 88% accuracy, 92% positive predictive value (PPV), and 82% negative predictive value (NPV).…”

Section: Introductionmentioning

confidence: 99%

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A glance at imaging bladder cancer

Salmanoglu

Halpern

Trabulsi

et al. 2018

Clin Transl Imaging

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Purpose Early and accurate diagnosis of Bladder cancer (BCa) will contribute extensively to the management of the disease. The purpose of this review was to briefly describe the conventional imaging methods and other novel imaging modalities used for early detection of BCa and outline their pros and cons. Methods Literature search was performed on Pubmed, PMC, and Google scholar for the period of January 2014 to February 2018 and using such words as “bladder cancer, bladder tumor, bladder cancer detection, diagnosis and imaging”. Results A total of 81 published papers were retrieved and are included in the review. For patients with hematuria and suspected of BCa, cystoscopy and CT are most commonly recommended. Ultrasonography, MRI, PET/CT using 18F-FDG or 11C-choline and recently PET/MRI using 18F-FDG also play a prominent role in detection of BCa. Conclusion For initial diagnosis of BCa, cystoscopy is generally performed. However, cystoscopy can not accurately detect carcinoma insitu (CIS) and can not distinguish benign masses from malignant lesions. CT is used in two modes, CT and computed tomographic urography (CTU), both for dignosis and staging of BCa. However, they cannot differentiate T1 and T2 BCa. MRI is performed to diagnose invasive BCa and can differentiate muscle invasive bladder carcinoma (MIBC) from non-muscle invasive bladder carcinoma (NMIBC). However, CT and MRI have low sensitivity for nodal staging. For nodal staging PET/CT is preferred. PET/MRI provides better differentiation of normal and pathologic structures as compared with PET/CT. Nonetheless none of the approaches can address all issues related for the management of BCa. Novel imaging methods that target specific biomarkers, image BCa early and accurately, and stage the disease are warranted.

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“…Radiología. 2017.Se ha reportado una sensibilidad del 89-100% y especificidad del 80-87%,(28)(29)(30) para el diagnóstico de CV con cistoscopia virtual, en comparación con 87-100% y 75-95% de la cistoscopia óptica, respectivamente (12). La sensibilidad disminuye en lesiones menores de 3 cm al igual que en la sospecha de tumor in situ, en estos casos es más fiable la visualización directa de las lesiones (29).…”

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Nuevas herramientas para el diagnóstico del cáncer de vejiga

2022

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Resumen El cáncer de vejiga es la undécima neoplasia maligna más frecuente a nivel mundial y conlleva una alta morbimortalidad. Para su diagnóstico, múltiples ayudas como la urotomografía y la cistoscopia, que permanecen como el estándar de oro en la actualidad. Se realizó una revisión narrativa en múltiples bases de datos (Medline, Scopus, ScienceDirect). El diagnóstico fotodinámico, al igual que la reconstrucción vesical por tomografía para realización de cistoscopia virtual son herramientas que se han introducido más recientemente. Asimismo, la ecografía contrastada y particularmente la Resonancia Magnética Multiparamétrica vesical con la clasificación de VI-RADS se han propuesto como alternativas novedosas. Éstos últimos son tal vez las herramientas más promisorias, sin embargo, se requieren más estudios que permitan recomendar su uso generalizado, que aún se vería limitado por su disponibilidad.

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Contrast enhanced ultrasound in urothelial carcinoma of urinary bladder: An underutilized staging and grading modality

Cited by 7 publications

References 11 publications

Contrast-enhanced ultrasound of small cell carcinoma in urinary bladder: a case report and review of literature

Contrast-enhanced ultrasound of small cell carcinoma in urinary bladder: a case report and review of literature

A glance at imaging bladder cancer

Nuevas herramientas para el diagnóstico del cáncer de vejiga

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