Contrast-enhanced ultrasound of histologically proven hepatic epithelioid hemangioendothelioma

Ye, Dong; Wang, Wenping; Cantisani, Vito; D’Onofrio, Mirko; Ignee, A.; Mulazzani, Lorenzo; Săftoiu, Adrian; Spârchez, Zeno; Sporea, Ioan; Dietrich, Christoph F.

doi:10.3748/wjg.v22.i19.4741

Cited by 50 publications

(72 citation statements)

References 38 publications

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“…The AUROC of SWE for differentiating hepatic hemangiomas from malignant hepatic tumors was 0.77 with a sensitivity of 72.7% and a specificity of 66.7%, using a cutoff value of 23.62 kPa. IContrast-enhanced ultrasound (CEUS) is used for the improved detection and characterization of focal liver lesions [75][76][77][78][79][80][81]. CEUS does not influence the measurement of liver stiffness [82].…”

Section: Focal Liver Lesionsmentioning

confidence: 99%

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

et al. 2018

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Featured Application: In this review we present and discuss the published literature on the use of ultrasound-based liver elastography in children. The published data show that all the available shear wave elastography techniques are feasible and accurate for the assessment of liver fibrosis in children with diffuse liver disease due to several etiologies. For the assessment of focal liver lesions evidences are limited and no conclusion can be drawn so far.Abstract: Studies performed using transient elastography (TE), point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) have shown that these techniques are all feasible and accurate in children for the evaluation of liver fibrosis due to several etiologies. However, for some specific pediatric pathologies, such as biliary atresia, the evidence is still limited. As shown in adults, inflammation is a confounding factor when assessing fibrosis severity and care should be taken when interpreting the results. Due to the scarce comparative data between serological tests and elastography techniques in children, a definite conclusion regarding which is the best cannot be drawn. Neither non-invasive elastographic techniques nor laboratory scores allow determination of the presence and the degree of inflammation, necrosis, iron or copper deposits.

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Section: Focal Liver Lesionsmentioning

confidence: 99%

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

et al. 2018

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“…Early detection and characterization of small FLLs may increase the chances of curative surgical resection or successful percutaneous ablation options of malignant tumours in early stages [8,9,11,14,22,23]. Conventional BMUS with low frequency convex transducer (1)(2)(3)(4)(5) is the first line imaging method for detecting and diagnosis of FLLs [4,5].…”

Section: Discussionmentioning

confidence: 99%

“…Detection of small FLLs of less than 5 mm always is challenging as these lesions often appear isoechoic on B mode ultrasound (BMUS); the same is true for superficial FLLs close to the liver capsule [6]. Over the last decade, with the wide clinical application of microbubble ultrasound contrast agents, contrastenhanced ultrasound (CEUS) has noticeably improved the identification and characterization of FLLs, especially for FLLs less than 10 mm in size [7][8][9][10][11][12]. However, it still proves to be difficult to differentiate malignant and benign FLLs, especially when the lesion is smaller than 10 mm or located superficially [2,13].…”

Section: Introductionmentioning

confidence: 99%

Detection and characterization of small superficially located focal liver lesions by contrast-enhanced ultrasound with high frequency transducers

Wang¹,

Dong²,

Cao³

et al. 2017

Med Ultrason

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Aim: To evaluate the benefits of contrast-enhanced ultrasound (CEUS) with high frequency transducers in the detection and characterization of small superficially located focal liver lesions (FLLs).Material and methods: From January 2015 to October 2016, 27 superficial FLLs detected by MRI were examined, first with the low frequency convex transducer (1-5 MHz) and afterwards with a high frequency transducer (7.5-12 MHz). High frequency dynamic CEUS was performed after a bolus injection of 2.4 ml SonoVue®. FLLs were confirmed by histopathology after surgery (n=18) or ultrasound guided 18-gauge core-needle biopsy (n=8), or by MRI follow-up (n =1).Results: The mean diameter of FLLs was 10.5±3.1 mm, and meandepth was 6.2±5.3 mm. While using a high frequency transducerthe detection rate of FLLs (100%, 27/27) was significantly higher than low frequency transducer (25.9%, 7/27) (p<0.05). The overall sensitivity, specificity and diagnostic accuracy were significantly improved by CEUS with a high frequency transducer (sensitivity 88.9%; specificity 92.6%; accuracy 96.2%).Conclusion: Combining CEUS with the performance of high-frequency transducers is a promising technique to improve the detection and accurate diagnosis of small and superficial FLLs appearing indistinctive on BMUS.

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“…4). Подчеркнем, что к настоящему времени рядом авторов определены достаточно четкие критерии дифференциальной диагностики между ме-тастазами, гемангиомами и нодулярной гиперплазией печени при проведении КУУЗИ [10][11][12][13]. По данным Y. Dong и соавт.…”

Section: опухоли женской репродуктивной системы Tumors Of Female Reprunclassified

“…По данным Y. Dong и соавт. [13], полученным на примере 45 паци-ентов, гемангиомы при КУУЗИ в артериальную фазу характеризуются периферическим накоплением ми-кропузырьков в центростремительном направлении и визуализацией гиперэхогенного очага в позднюю фазу в 98 % случаев. Таким образом, вышеизложенные данные позволили нам в этом наблюдении сузить диф-ференциальный ряд в пользу метастатического пора-жения печени.…”

Section: опухоли женской репродуктивной системы Tumors Of Female Reprunclassified

The Ability of Contrast-Enhanced Ultrasound in the Diagnosis of Liver Metastases in Cervical Cancer

Кряжева¹,

Чекалова²,

Мусаева³

et al. 2017

Tumors of female reproductive system

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Contrast-enhanced ultrasound of histologically proven hepatic epithelioid hemangioendothelioma

Abstract: CEUS allows for characterization of unequivocal FLL. By analyzing the hypoenhancement in the PVLP, CEUS can determine the malignant nature of HEHE.

Cited by 50 publications

References 38 publications

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

Detection and characterization of small superficially located focal liver lesions by contrast-enhanced ultrasound with high frequency transducers

The Ability of Contrast-Enhanced Ultrasound in the Diagnosis of Liver Metastases in Cervical Cancer

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