Contrast-enhanced ultrasound of transplant organs — liver and kidney — in children

Franke, Doris; Daugherty, Reza; Ključevšek, Damjana; Ntoulia, Aikaterini; Rafailidis, Vasileios; Takahashi, Marcelo Straus; Torres, Alvaro; Viteri, Bernarda; Volberg, Frank M.

doi:10.1007/s00247-020-04867-y

Cited by 16 publications

(19 citation statements)

References 98 publications

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“…The kidney is the most commonly transplanted solid organ in the world and ongoing efforts are being made in order to improve graft survival rates [30]. In the multidisciplinary approach to reducing the risk of early and late renal graft failure, imaging evaluation and surveillance are fundamental components [30,31]. Several complications may lead to graft failure following the transplantation, including vascular complications, allograft rejection, complications of the urinary tract,…”

Section: Kidney Transplant Monitoringmentioning

confidence: 99%

“…peritransplant fluid collections, infections, and focal parenchymal lesions such as malignancy [31,32]. Conventional color Doppler is generally the first-line modality for evaluating the presence of complications after renal transplantation due to its wide accessibility, safety profile, and accuracy in early identification of most allograft-related complications [30,31,33].…”

Section: Kidney Transplant Monitoringmentioning

confidence: 99%

“…In order to overcome this limitation, CEUS has become increasingly popular as a tool for evaluating kidney transplant recipients [32]. By providing information about renal vascular structures and parenchymal perfusion, CEUS has been proven to have a high diagnostic value for detecting post-transplant complications [31,32,33]. The ability of CEUS to provide quantitative and qualitative information about the capillaries and microvascular perfusion of the renal parenchyma provides greater diagnostic significance than power/color Doppler [34].…”

Section: Kidney Transplant Monitoringmentioning

confidence: 99%

“…It was found that CEUS exams were conclusive in 93% of cases [35]. In several clinical studies, CEUS has been shown to offer excellent diagnostic accuracy for allograft-related complications, especially for graft rejection, vascular complications, and malignancies [31,32]. Detection of graft dysfunction relies largely on monitoring renal function tests (i.e., serum creatinine, glomerular filtration rate, proteinuria), but radiological imaging serves an essential role in detecting acute rejection [30].…”

Section: Kidney Transplant Monitoringmentioning

confidence: 99%

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Renal Contrast-enhanced Ultrasound: Clinical Applications and Emerging Researc

Velasquez-Botero¹,

Ananya²,

Tang³

et al. 2022

ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY

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Contrast-enhanced ultrasound (CEUS) is an imaging modality that has achieved considerable relevance in various clinical settings including the assessment of renal disease. CEUS is performed by injecting microbubble-based ultrasound contrast agents (UCAs) that create signals to display the microvasculature, allowing quantitative and qualitative assessment of parenchymal perfusion and real-time visualization of the renal anatomy. In recent years, CEUS has been widely accepted and applied for the assessment of kidney perfusion and the characterization of indeterminate renal masses, primarily due to its diagnostic efficacy, availability, low cost, reproducibility, and absence of nephrotoxicity. CEUS provides a higher spatial and temporal resolution than other cross-sectional imaging, resulting in high sensitivity and specificity for its applications in a variety of renal conditions including cancer monitoring following ablation, detection of transplant complications, hypoperfusion, acute traumatic injury, renal artery stenosis, parenchymal infection, and kidney intervention guidance. Additionally, the continuous investigation and development of new technologies surrounding this imaging technique have shown encouraging preliminary results for the use of CEUS in the evaluation of molecular expression in several disease processes, the dynamic analysis of blood flow kinetics, and the implementation of super-resolution imaging systems. The purpose of this article is to provide an overview of the current and potential clinical applications of renal CEUS.

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Section: Kidney Transplant Monitoringmentioning

confidence: 99%

Section: Kidney Transplant Monitoringmentioning

confidence: 99%

Section: Kidney Transplant Monitoringmentioning

confidence: 99%

Section: Kidney Transplant Monitoringmentioning

confidence: 99%

See 2 more Smart Citations

Renal Contrast-enhanced Ultrasound: Clinical Applications and Emerging Researc

Velasquez-Botero¹,

Ananya²,

Tang³

et al. 2022

ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY

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“…Other CEUS applications for liver imaging include trauma, post-liver transplantation, and interventional procedures. These are covered in detail in other articles in this supplement [36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Contrast-enhanced ultrasound of benign and malignant liver lesions in children

et al. 2021

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Contrast-enhanced ultrasound (CEUS) is increasingly being used in children. One of the most common referrals for CEUS performance is characterization of indeterminate focal liver lesions and follow-up of known liver lesions. In this setting, CEUS is performed with intravenous administration of ultrasound contrast agents (UCAs). When injected into a vein, UCA microbubbles remain confined within the vascular network until they dissipate. Therefore, visualization of UCA within the tissues and lesions corresponds to true blood flow. CEUS enables continuous, real-time observation of the enhancement pattern of a focal liver lesion, allowing in most cases for a definite diagnosis and obviating the need for further cross-sectional imaging or other interventional procedures. The recent approval of Lumason (Bracco Diagnostics, Monroe Township, NJ) for pediatric liver CEUS applications has spurred the widespread use of CEUS. In this review article we describe the role of CEUS in pediatric liver applications, focusing on the examination technique and interpretation of main imaging findings of the most commonly encountered benign and malignant focal liver lesions. We also compare the diagnostic performance of CEUS with other imaging modalities for accurate characterization of focal liver lesions.

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