Contrast‐Enhanced Ultrasound (<scp>CEUS</scp>) in the Evaluation of Hemoperitoneum in Patients With Cirrhosis

Abushamat, Farid; Dietrich, Christoph F.; Clevert, D.‐A.; Piscaglia, Fabio; Fetzer, David T.; Meloni, Maria Franca; Shiehmorteza, Masoud; Kono, Yuko

doi:10.1002/jum.16002

Cited by 2 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultrasonography is a versatile modality that offers irreplaceable advantages such as rapid availability in an emergency setting and easy application to patients who are bedridden, critically ill, or difficult to transport to the radiology department for a CT scan [ 3 , 18 , 19 ]. Moreover, CEUS has advantages in terms of safety issues.…”

Section: Discussionmentioning

confidence: 99%

Upper gastrointestinal tract perforation assessed by contrast-enhanced ultrasonography after oral Sonazoid administration in a stomach leakage mouse model

et al. 2023

View full text Add to dashboard Cite

Purpose: The purpose of this study was to elucidate whether contrast-enhanced ultrasonography (CEUS) can visualize orally administered Sonazoid leaking into the peritoneal cavity in a postoperative stomach leakage mouse model.Methods: Adult female mice (n=33, 9-10 weeks old) were used. Preoperative CEUS was performed after delivering Sonazoid via intraperitoneal injection and the per oral route. A gastric leakage model was then generated by making a surgical incision of about 0.5 cm at the stomach wall, and CEUS with per oral Sonazoid administration was performed. A region of interest was drawn on the CEUS images and the signal intensity was quantitatively measured. Statistical analysis was performed using a mixed model to compare the signal intensity sampled from the pre-contrast images with those of the post-contrast images obtained at different time points.Results: CEUS after Sonazoid intraperitoneal injection in normal mice and after oral administration in mice with gastric perforation visualized the contrast medium spreading within the liver interlobar fissures continuous to the peritoneal cavity. A quantitative analysis showed that in the mice with gastric perforation, the orally delivered Sonazoid leaking into the peritoneal cavity induced a statistically significant (P<0.05) increase in signal intensity in all CEUS images obtained 10 seconds or longer after contrast delivery. However, enhancement was not observed before gastric perforation surgery (P=0.167).Conclusion: CEUS with oral Sonazoid administration efficiently visualized the contrast medium spreading within the peritoneal cavity in a postoperative stomach leakage mouse model.

show abstract

Section: Discussionmentioning

confidence: 99%

Upper gastrointestinal tract perforation assessed by contrast-enhanced ultrasonography after oral Sonazoid administration in a stomach leakage mouse model

et al. 2023

View full text Add to dashboard Cite

show abstract

“…However, US has shown some limitations in patients with small-sized tumors [ 50 , 51 ]. CEUS is another useful test since it has an elevated resolution and shows in real time hemorrhage from spontaneous or non-spontaneous rupture [ 52 ]. It usually displays HCC as contrast-enhancing lesions with quick, subsequent washout [ 53 ].…”

Section: Introductionmentioning

confidence: 99%

Spontaneously Ruptured Hepatocellular Carcinoma: Computed Tomography-Based Assessment

et al. 2023

View full text Add to dashboard Cite

Spontaneously ruptured hepatocellular carcinoma (SRHCC) is an uncommon and life-threatening complication in patients with hepatocellular carcinoma (HCC). It is usually associated with chronic liver disease and has a poor prognosis with a high mortality rate during the acute phase. SRHCC can cause a severe and urgent condition of acute abdomen disease and requires a correct diagnosis to achieve adequate treatment. Clinical presentation is related to the presence of hemoperitoneum, and abdominal pain is the most common symptom (66–100% of cases). Although the treatment approach is not unique, trans-arterial (chemo)embolization (TAE/TACE) followed by staged hepatectomy has shown better results in long-term survival. A multi-phase contrast-enhanced CT (CECT) scan is a pivotal technique in the diagnosis of SRHCC due to its diagnostic accuracy and optimal temporal resolution. The correct interpretation of the main CT findings in SRHCC, such as active contrast extravasation and the sentinel clot sign, is fundamental for a prompt and correct diagnosis. Furthermore, CT also plays a role as a post-operative control procedure, especially in patients treated with TAE/TACE. Therefore, a multi-phase CECT scan should be the diagnostic tool of choice in SRHCC since it suggests an immediate need for treatment with a consequent improvement in prognosis.

show abstract

Contrast‐Enhanced Ultrasound (CEUS) in the Evaluation of Hemoperitoneum in Patients With Cirrhosis

Cited by 2 publications

References 15 publications

Upper gastrointestinal tract perforation assessed by contrast-enhanced ultrasonography after oral Sonazoid administration in a stomach leakage mouse model

Upper gastrointestinal tract perforation assessed by contrast-enhanced ultrasonography after oral Sonazoid administration in a stomach leakage mouse model

Spontaneously Ruptured Hepatocellular Carcinoma: Computed Tomography-Based Assessment

Contact Info

Product

Resources

About