Contrast-Enhanced Ultrasound with Perflubutane in the Assessment of Anti-Angiogenic Effects: Early Prediction of the Anticancer Activity of Bevacizumab in a Mouse Xenografted Model

Watanabe, Rira; Munemasa, Toshiko; Matsumura, Manabu

doi:10.1016/j.ultrasmedbio.2015.04.018

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…It may be that the warm ischemia time is not the only determinant of kidney injury and each individual may have different tolerance to ischemic insult and renal functional recovery ability. CEUS was also used to evaluate anti-angiogenic effects and even treat cancer by synergistic effects in animal models [ 20 – 23 ]. A preliminary study reported that CEUS was used to assess the protective role of a gonadotropin-releasing hormone analog from chemotherapy-induced ovarian damage in a murine model [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…A preliminary study reported that CEUS was used to assess the protective role of a gonadotropin-releasing hormone analog from chemotherapy-induced ovarian damage in a murine model [ 21 ]. CEUS with perflubutane in the assessment of anti-angiogenic effects by bevacizumab in a mouse xenografted model was also reported [ 23 ]. These preclinical experiments with translational aims have laid an important foundation for the wide application of CEUS in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of renal ischemia–reperfusion injury using CEUS in mice

Xu,

Zhao,

Huang

et al. 2023

Eur Radiol Exp

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Background Renal ischemia–reperfusion injury (IRI) frequently occurs clinically. We investigated the value of contrast-enhanced ultrasonography (CEUS) in the evaluation of renal IRI levels in mice. Methods Thirty-six healthy adult male C57BL/6 mice (20–22 g) were randomly divided into the sham, 10 min, 20 min, 30 min, 40 min, and 50 min groups based on the time of renal warm ischemia by blocking the left renal pedicle, approved by the Institutional Animal Ethics Committee. Time-intensity curve (TIC)-derived parameters such as peak enhancement (PE) and wash-in perfusion index (WiPI) were produced using CEUS at 1 h and 24 h after IRI. The severity of kidney injury was detected by the renal tubular necrosis rate which was analyzed by hematoxylin and eosin staining at 24 h after IRI. The Spearman correlation coefficient was used to describe the correlations between PE and WiPI values and the renal tubular necrosis rate. Results The PE and WiPI values decreased after IRI in the groups with a warm ischemia time ≥ 20 min. The renal tubular necrosis rate was significantly correlated with the PE value at 1 h (ρ = -0.802) and 24 h (ρ = -0.861) after IRI and the WiPI value at 1 h (ρ = -0.814) and 24 h (ρ = -0.853) after IRI (all p < 0.001). Conclusion TIC-derived parameters, including PE and WiPI values, can be used to evaluate the severity of renal IRI in mice. CEUS is a safe and effective technology for the detection of renal IRI. Relevance statement CEUS can evaluate the severity of renal ischemia–reperfusion injury by peak enhancement and wash-in perfusion index values selected from various time-intensity curve-derived parameters. Key points • Contrast-enhanced ultrasonography can evaluate the level of renal ischemia–reperfusion injury. • Peak enhancement and wash-in perfusion index are correlated with the renal tubular necrosis rate. • CEUS can detect changes in unilateral renal function without radiation. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of renal ischemia–reperfusion injury using CEUS in mice

Xu,

Zhao,

Huang

et al. 2023

Eur Radiol Exp

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“… 26 , 44 Previous studies consistently demonstrated that CEUS could predict the efficacy of drugs that target angiogenesis at an early stage, which is a reference important for the precise treatment of liver cancer and possibly prolonging life. 44 , 45 …”

Section: Application Of Ultrasound Technologies In Different Stages O...mentioning

confidence: 99%

Ultrasonography of Hepatocellular Carcinoma: From Diagnosis to Prognosis

Hu,

Zhao,

et al. 2024

J Clin Transl Hepatol

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Hepatocellular carcinoma (HCC) is a prominent contributor to cancer-related mortality worldwide. Early detection and diagnosis of liver cancer can significantly improve its prognosis and patient survival. Ultrasound technology, serving has undergone substantial advances as the primary method of HCC surveillance and has broadened its scope in recent years for effective management of HCC. This article is a comprehensive overview of ultrasound technology in the treatment of HCC, encompassing early detection, diagnosis, staging, treatment evaluation, and prognostic assessment. In addition, the authors summarized the application of contrast-enhanced ultrasound in the diagnosis of HCC and assessment of prognosis. Finally, the authors discussed further directions in this field by emphasizing overcoming existing obstacles and integrating cutting-edge technologies.

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Image Monitoring of the Impaired Phagocytic Activity of Kupffer Cells and Liver Oxygen Saturation in a Mouse Cholangitis Model Using Contrast-Enhanced Ultrasound Imaging and Photoacoustic Imaging

Lee

Choi

2017

Ultrasound in Medicine & Biology

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Contrast-Enhanced Ultrasound with Perflubutane in the Assessment of Anti-Angiogenic Effects: Early Prediction of the Anticancer Activity of Bevacizumab in a Mouse Xenografted Model

Cited by 4 publications

References 35 publications

Evaluation of renal ischemia–reperfusion injury using CEUS in mice

Evaluation of renal ischemia–reperfusion injury using CEUS in mice

Ultrasonography of Hepatocellular Carcinoma: From Diagnosis to Prognosis

Image Monitoring of the Impaired Phagocytic Activity of Kupffer Cells and Liver Oxygen Saturation in a Mouse Cholangitis Model Using Contrast-Enhanced Ultrasound Imaging and Photoacoustic Imaging

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