Contrast-induced acute kidney injury and mortality in ST elevation myocardial infarction treated with primary percutaneous coronary intervention

Silvain, Jean‐François; Nguyen, Lee S.; Spagnoli, Vincent; Kernéis, Mathieu; Guedeney, Paul; Vignolles, Nicolas; Cosker, K.; Barthélémy, Olivier; Feuvre, Claude Le; Helft, Gérard; Collet, Jean‐Philippe; Montalescot, Gilles

doi:10.1136/heartjnl-2017-311975

Cited by 52 publications

(36 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients presenting with STEMI are prone to develop CI-AKI after primary PCI, and high thrombogenic state and inflammation are among the leading causes [5]. Hyperglycemic patients presenting with STEMI have higher coronary thrombus burden compared with thrombi from normoglycemic counterparts.…”

Section: Discussionmentioning

confidence: 99%

“…The highest serum creatinine level within 2 days after coronary angiography was used as post PCI creatinine to diagnose CI-AKI. The diagnostic criteria of CI-AKI was an elevation in serum creatinine ≥ 27 μmol/l or ≥ 50 per-cent over baseline within 48 h after contrast media injection [5]. Then the association between continuous metformin therapy in the perioperative period and incidences of CI-AKI was examined.…”

Section: Primary Outcomementioning

confidence: 99%

“…ST-elevation myocardial infarction (STEMI) patients with CI-AKI after coronary stent implantation had longer hospital stays, increased adverse cardiovascular outcomes, and higher mortality [2]. As the direct toxicity of contrast media, the high thrombogenic state, inflammation, and the decrease in renal perfusion, patients submitted to primary PCI for STEMI are at high-risks for CI-AKI, [5]. According to different definition, the incidence of CI-AKI can range from approximately 6.4 to 27.7% in STEMI patients after primary PCI [6].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of continuous use of metformin on kidney function in diabetes patients with acute myocardial infarction undergoing primary percutaneous coronary intervention

Zhu

Liu

2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background: Diabetes patients presenting with ST-segment elevation myocardial infarction (STEMI) scheduled for primary percutaneous coronary intervention (PCI) have an increased risk of contrast induced-acute kidney injury (CI-AKI). The effects of continuous use of metformin on kidney function are still controversial in patients submitted to primary PCI. This study aimed to assess continuous metformin therapy on kidney function in diabetic patients undergoing coronary intervention. Methods: Two hundred eighty-four patients with metformin-treated diabetes, who underwent coronary intervention within 24 h for STEMI, were enrolled in the retrospective study. All the patients had estimated glomerular filtration rate (eGFR) of > 30 mL/min/1.73 m 2 . According to the physicians' decisions after admission, 119 patients continued metformin treatment after primary PCI, while 165 patients discontinued it > 48 h after the procedure. Serum creatinine was collected at admission and within 48 h post primary PCI to evaluate the incidence of CI-AKI. We performed a multiple logistic regression analysis to examine the determinants of CI-AKI. Results: No statistical difference in CI-AKI incidence between the continuous and the discontinuous metformin group (12.6%vs10.3%, p = 0.545). Multivariable logistic regression analysis indicated eGFR ≤60 ml/min/1.73 m 2 [p = 0.025, OR: 3.131; 95% CI (1.156-8.482)] and contrast volume [p = 0.002, OR: 1.010; 95% CI (1.004-1.016)] were predictive factors of CI-AKI. Metformin therapy was irrelevant to CI-AKI [p = 0.365, OR: 0.698; 95% CI (0.320-1.521)]. No case of lactic acidosis was found in this study. Besides, the study supported discontinuation of metformin was not beneficial for patients' blood glucose control after admission. Conclusions: The study indicated that the metformin continuation after primary PCI for STEMI in diabetic patients with eGFR > 30 ml/min / 1.73 m 2 did not increase the risk of CI-AKI.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Primary Outcomementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of continuous use of metformin on kidney function in diabetes patients with acute myocardial infarction undergoing primary percutaneous coronary intervention

Zhu

Liu

2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…In patients with acute myocardial infarction with ST-elevation (STEMI) percutaneous revascularization with primary PCI (pPCI) represents the mainstay of acute treatment. The incidence of CI-AKI in patients treated with pPCI during STEMI varies from 10.5% to 18.3% depending on the definition used for CI-AKI, with a significant impact on mortality (Silvain et al, 2018).…”

Section: Clinical-epidemiological Impact Of Ci-akimentioning

confidence: 99%

Contrast induced acute kidney injury in interventional cardiology: an update and key guidance for clinicians

Ronco

Tarantini²,

McCullough

2020

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

Contrast-induced acute kidney injury (CI-AKI) is a serious complication that can affect outcome and prognosis of patients undergoing percutaneous diagnostic and interventional procedures in catheterization laboratories. There have been advancements in case definition and epidemiology. Additionally strategies have emerged that are positioned to have impact in the catheterization laboratory for patients undergoing cardiovascular procedures. The aim of this review is to provide the state-of-the-art of diagnosis, prevention and management of CI-AKI in interventional cardiology.

show abstract

“…Contrast volume media is an important risk factor for CIN. 4,5 Because of the longer duration of coronary interventions and repeated cine-angiographic views, we proposed that the use of contrast media volume in patients with large thrombus burden might be higher than the other patients. Demonstrating the contrast media volume in table 2 and performing logistic regression analysis after stratifying contrast media volume could better represent the association.…”

mentioning

confidence: 99%

What Are the Essential Risk Factors for Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction?

Keskin¹,

Kaya

Çınar³

et al. 2019

Angiology

View full text Add to dashboard Cite

Contrast-induced acute kidney injury and mortality in ST elevation myocardial infarction treated with primary percutaneous coronary intervention

Abstract: CI-AKI is a frequent and serious complication of STEMI treated by pPCI. The RIFLE definition is the most accurate definition to identify patients with CI-AKI at high risk of mortality or haemodialysis.

Cited by 52 publications

References 29 publications

Effect of continuous use of metformin on kidney function in diabetes patients with acute myocardial infarction undergoing primary percutaneous coronary intervention

Effect of continuous use of metformin on kidney function in diabetes patients with acute myocardial infarction undergoing primary percutaneous coronary intervention

Contrast induced acute kidney injury in interventional cardiology: an update and key guidance for clinicians

What Are the Essential Risk Factors for Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction?

Contact Info

Product

Resources

About