Contrast-induced nephropathy in an animal model: Evaluation of novel biomarkers in blood and tissue samples

Mamoulakis, Charalampos; Fragkiadoulaki, Irene; Karkala, Phaedra; Georgiadis, Georgios; Zisis, Ioannis-Erineos; Stivaktakis, Polychronis; Kalogeraki, Alexandra; Tsiaoussis, Ioannis; Burykina, Tatyana I.; Lazopoulos, George; Tsarouhas, Konstantinos; Kouretas, Demetrios; Tsatsakis, Aristidis

doi:10.1016/j.toxrep.2019.04.007

Cited by 30 publications

(22 citation statements)

References 49 publications

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“…A strong and consistent relationship has been established between lipid peroxidation products of oxidative stress and nephrotoxicity by a number of studies [5,6]. Reactive oxygen species (ROS) produced by antineoplastic agents facilitate cytotoxicity, for example - cisplatin-induced nephro- and neurotoxicity, doxorubicin-induced cardiotoxicity, which in turn reduce the efficacy of these drugs in treating cancer [7].…”

Section: Introductionmentioning

confidence: 99%

“…Extract of Indian gooseberry leaves demonstrated antioxidant and renoprotective effect in cisplatin-induced nephrotoxicity [8]. Moreover, contrast media-induced organ toxicity specially nephrotoxicity is one of the major concerns nowadays [6,9]. Again, natural products with antioxidant and free radical scavenging ability have the potential benefiacial effect in the prevention and treatment of organ toxicity.…”

Section: Introductionmentioning

confidence: 99%

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Renoprotective effects of stevia (Stevia rebaudiana Bertoni), amlodipine, valsartan, and losartan in gentamycin-induced nephrotoxicity in the rat model: Biochemical, hematological and histological approaches

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Renoprotective effects of stevia (Stevia rebaudiana Bertoni), amlodipine, valsartan, and losartan in gentamycin-induced nephrotoxicity in the rat model: Biochemical, hematological and histological approaches

et al. 2019

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“…CIN is a real, albeit rare, entity in current clinical medical practice that represents a serious iatrogenic AKI form, occurring 24-72 h after administration of iodinated contrast media (CM) during angiographic or other procedures, such as urography [3,25]. The exact pathophysiology of CIN is not fully elucidated but oxidative stress is considered a major mechanism in CIN [26], and the identification of novel biomarkers that may more accurately detect renal function changes, reflect kidney damage, assist monitoring, and elucidate pathophysiology have attracted considerable scientific attention nowadays [27]. CM passing through the kidney results in an intense tubular transport that increases the activity in the thick ascending limb of Henle's loop.…”

Section: Introductionmentioning

confidence: 99%

Current Concepts on the Reno-Protective Effects of Phosphodiesterase 5 Inhibitors in Acute Kidney Injury: Systematic Search and Review

Georgiadis

Zisis

Docea

et al. 2020

JCM

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Acute kidney injury (AKI) is associated with increased morbidity, prolonged hospitalization, and mortality, especially in high risk patients. Phosphodiesterase 5 inhibitors (PDE5Is), currently available as first-line therapy of erectile dysfunction in humans, have shown a beneficial potential of reno-protection through various reno-protective mechanisms. The aim of this work is to provide a comprehensive overview of the available literature on the reno-protective properties of PDE5Is in the various forms of AKI. Medline was systematically searched from 1946 to November 2019 to detect all relevant animal and human studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. In total, 83 studies were included for qualitative synthesis. Sildenafil is the most widely investigated compound (42 studies), followed by tadalafil (20 studies), icariin (10 studies), vardenafil (7 studies), zaprinast (4 studies), and udenafil (2 studies). Even though data are limited, especially in humans with inconclusive or negative results of only two clinically relevant studies available at present, the results of animal studies are promising. The reno-protective action of PDE5Is was evident in the vast majority of studies, independently of the AKI type and the agent applied. PDE5Is appear to improve the renal functional/histopathological alternations of AKI through various mechanisms, mainly by affecting regional hemodynamics, cell expression, and mitochondrial response to oxidative stress and inflammation.

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“…Contrast-induced nephropathy is a classic example of reversible acute kidney injury (AKI) with tubular involvement [ 1 ]. Animal and human studies showed that contrast administration triggers both systemic and renal cytotoxic effects [ 2 , 3 ]. However, if the conditions are unfavorable, further irreversible changes may lead to progression to chronic kidney disease [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Clusterin as a New Marker of Kidney Injury in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Pilot Study

Musiał

Augustynowicz

Miśkiewicz-Migoń

et al. 2020

JCM

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Background and aims: The markers of renal damage defining subclinical AKI are not widely used in children undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). The aim of the study was to evaluate serum and urinary clusterin as indices of kidney injury after alloHSCT in relation to damage (kidney injury molecule (KIM)-1) and functional (cystatin C) markers. Material and methods: Serum and urinary clusterin, KIM-1 and cystatin C concentrations were assessed by ELISA in 27 children before alloHSCT, 24 h, 1, 2, 3 and 4 weeks after alloHSCT and in controls. Results: All parameters were significantly higher in HSCT patients compared to controls even before the transplantation. The serum concentrations increased after HSCT and this rising trend was kept until the third (clusterin) or 4th (KIM-1, cystatin C) week. Urinary clusterin and KIM-1 were elevated until the third week and then decreased yet remained higher than before HSCT. Urinary cystatin C has risen from the second week after HSCT and decreased after the third week but was still higher than before alloHSCT. Conclusions: The features of kidney injury are present even before alloHSCT. Clusterin seems useful in the assessment of subclinical AKI and may become a new early marker of sublethal kidney injury in children.

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Contrast-induced nephropathy in an animal model: Evaluation of novel biomarkers in blood and tissue samples

Abstract: Graphical abstract

Cited by 30 publications

References 49 publications

Renoprotective effects of stevia (Stevia rebaudiana Bertoni), amlodipine, valsartan, and losartan in gentamycin-induced nephrotoxicity in the rat model: Biochemical, hematological and histological approaches

Renoprotective effects of stevia (Stevia rebaudiana Bertoni), amlodipine, valsartan, and losartan in gentamycin-induced nephrotoxicity in the rat model: Biochemical, hematological and histological approaches

Current Concepts on the Reno-Protective Effects of Phosphodiesterase 5 Inhibitors in Acute Kidney Injury: Systematic Search and Review

Clusterin as a New Marker of Kidney Injury in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Pilot Study

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