Contrast-Induced Nephropathy

Rudnick, Michael R.; Feldman, Harold I.

doi:10.2215/cjn.03690907

Cited by 145 publications

(128 citation statements)

References 20 publications

Supporting

Mentioning

120

Contrasting

Unclassified

Order By: Relevance

“…1 Although, mostly, there are no permanent sequelae of radiocontrast nephropathy (RCN), its development may be associated with bad consequences. 2 The best way to avoid these consequences is to prevent RCN. A variety of preventive measures may reduce the risk.…”

Section: Introductionmentioning

confidence: 99%

Effect of sodium bicarbonate in an experimental model of radiocontrast nephropathy

et al. 2010

View full text Add to dashboard Cite

Aim:The aim of this study is to investigate the efficacy and mechanism of action of intravenous (IV) bicarbonate in preventing radiocontrast nephropathy (RCN). Materials and methods: Twenty-eight Wistar rats were randomized into four groups including control (group 1), radiocontrast (group 2), bicarbonate (group 3), and radiocontrast plus bicarbonate (group 4). Once blood chemistry and arterial blood gases were examined and 24 h urine samples were collected, all rats were administered furosemide (2 mg/kg subcutaneous) and deprived of water for 24 h. Iothalamate sodium (6 mL/kg) was administered to group 2 and group 4. IV bicarbonate (8.4%) was administered to group 3 and group 4 (3 h before the administration of iothalamate). On the fourth day, 24 h urine was collected, and at the end of the day rats were sacrificed and blood chemistry and arterial blood gases were reexamined. Myeloperoxidase (MPO), nitric oxide (NO), total glutathione, and malondialdehyde were quantified on the renal tissue. H&E slides were examined. Results: Basal creatinine and creatinine clearance were similar between groups. There was no significant difference between creatinine and creatinine clearance by the end of the experiment. Glutathione level in group 2 was lower than in group 4. Histopathologically, there was no injury in the control group (group 1) whereas there was an intermediate-severe injury (71.4%) in the radiocontrast group (group 2). The percentage of intermediate-severe injury was significantly lower (71.4% vs. 28.6%, p = 0.02) in the radiocontrast plus bicarbonate group (group 4). Conclusions: Sodium bicarbonate attenuates the development of radiocontrast-induced tubular necrosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of sodium bicarbonate in an experimental model of radiocontrast nephropathy

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Previous reports indicated that CIN occurs in 4 to 20% of patients after intra-arterial administration after coronary angiography [13,14]. Many patients who undergo formal angiography including coronary angiography are admitted in the hospitals, causing a different physiologic status than ambulatory patients.…”

Section: Discussionmentioning

confidence: 99%

The Incidence of Contrast-Induced Nephropathy in Saudi Population after Cardiac Catheterization

2017

JCCR

View full text Add to dashboard Cite

Background: Contrast-induced nephropathy CIN is an acute deterioration of renal function defined as the increase in serum creatinine by 25% above the baseline value within 48 h after administration of contrast agent, several risk factors may aggravate CIN and DM is a strong predisposing factor. Objectives:To study the effect of contrast administration on renal function, and the relation of diabetes mellitus and other risk factors which can predispose patients to CIN in our local hospital. Methods:Open-label, single center study. A total of 1117 patients underwent cardiac catheterization between January and December 2009, all patients with acute coronary syndrome, and stable CAD were included.Results: Among 1117 patients, the incidence of CIN was (4.9%) and this represents 55patients. Out of those 55 patients, 35 (64%) patients were diabetic, 39 (71%) patients were hypertensive, 38 (56%) patients under went diagnostic cardiac catheterization, 17 (34%) had PCI, 23 (41%) patients had body weight <70 kg, and 44 (80%) patients received omnipauqe contrast media. Conclusion:The incidence of CIN was 4.9 %, and this concludes that hypertension and DM are the major risk factors in Saudi patients, diabetic patients in particular should be closely monitored for CIN and preventive measures should be strictly enforced. The Incidence of Contrast-Induced Nephropathy in Saudi Population after Cardiac Catheterization 2/4 CitationCopyright: ©2017 Balghith the time of enrollment. Two contrast media was used, Omnipaque and Visipaque Iohexol (Omnipaque) is a non-ionic, monomer, 350 mgI/ml with low osmolality of 884. The other contrast media was Iodixanol (Visipaque) which is a non-ionic,dimer, 320 mgI/ml with low osmolality of 290. Definition of CINContrast-induced nephropathy was defined as a 25% increase in the creatinine value from the baseline reading in the 2 nd to 3 rd day post-cath. Statistical analysisData were entered in Excel and analyzed using SPSS version 19.0 for Windows (SPSS, Chicago, IL, USA). Demographic characteristics are presented for continuous variables as means and standard deviations and categorical variables as frequencies and percentages. CIN and non-CIN patients were compared using the Chi-square test for categorical variables and Student's t-test for continuous variables. Significance was set at the 0.05 level. ResultsA total of 1117 patients underwent coronary angiography. The mean age of the study cohort was 55.7 (±11.6), and 81.4 % were males. The incidence of CIN was (4.9%) and this represents 55patients ( Figure 1). The 1117 patients, underwent two types of procedures, 675 patients underwent diagnostic cath and 442 had PCI ( Figure 2). Furthermore, out of the 55 patients who developed CIN a 38 (56%) patient underwent diagnostic cardiac cath, 17 (34%) had PCI, and 23 (41%) patients had body weight <70 kg. In this study two types of contrast media were used, the number of patients who received Omipaquie contrast was 1012, and only 105 received visipuqe. Among the 55 patients who developed contra...

show abstract

“…The mechanisms of development of CIN are not completely understood yet. 3,4 Despite the observation that diabetic patients undergoing PCI are at an increased risk for developing CIN, no definite pharmacological therapy has been defined for preventive practice. Thus, the identification of patients who are at an enhanced risk of development of CIN is pertinent.…”

Section: Original Articlementioning

confidence: 99%

Frequency of Contrast Induced Nephropathy (CIN) Following Exposure to Contrast in Coronary Angiography, in Diabetics with Previously Normal Renal Function

Sajjad¹,

Ali²,

Akram³

2016

Annals KEMU

View full text Add to dashboard Cite

Introduction: Contrast -induced nephropathy (CIN), is an acute kidney injury state, which has managed to catch the attention of cardiologists, as a result of increasing cardiac invasive interventions. Lately there has been a lot of research to get insight in the etiology, pathogenesis, recognition, diagnosis and prevention of CIN, so that the long term adverse effects can be avoided. Much of the research has been in the form of retrospective or observational studies on groups of patients undergoing angiographic contrast exposure. Objective: The objective of the study was to: Determine the frequency of CIN in diabetics undergoing coronary angiography. Study Design: Case series. Settings:

show abstract

Contrast-Induced Nephropathy

Cited by 145 publications

References 20 publications

Effect of sodium bicarbonate in an experimental model of radiocontrast nephropathy

Effect of sodium bicarbonate in an experimental model of radiocontrast nephropathy

The Incidence of Contrast-Induced Nephropathy in Saudi Population after Cardiac Catheterization

Frequency of Contrast Induced Nephropathy (CIN) Following Exposure to Contrast in Coronary Angiography, in Diabetics with Previously Normal Renal Function

Contact Info

Product

Resources

About