Contrast induced nephropathy: updated ESUR Contrast Media Safety Committee guidelines

Stacul, Fulvio; Molen, Aart J. van der; Reimer, Peter; Webb, Judith A. W.; Thomsen, Henrik S.; Morcos, Sameh K.; Almén, Torsten; Aspelin, Peter; Bellin, Marie‐France; Clémеnt, Olivier; Heinz-Peer, Gertraud

doi:10.1007/s00330-011-2225-0

Cited by 776 publications

(733 citation statements)

References 152 publications

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“…Current guidelines recommend monitoring SCr post CM exposure to detect CI‐AKI 5. Clinical studies also revealed that CyC is a reliable biomarker of CI‐AKI 14.…”

Section: Discussionmentioning

confidence: 99%

“…Early diagnosis is critical for patients because CI‐AKI causes time‐related injury to the kidney 4. CI‐AKI is now typically defined as an increase in serum creatinine (SCr), meeting one of several criteria, and occurring within 72 hours after intravascular administration of contrast medium (CM) 5. However, creatinine is an unreliable index of CI‐AKI because it is an indirect and insensitive indicator during acute changes in kidney function 4.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Circulating MicroRNA‐188, ‐30a, and ‐30e as Early Biomarkers for Contrast‐Induced Acute Kidney Injury

Sun

Zhang

Ding

et al. 2016

JAHA

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BackgroundContrast‐induced acute kidney injury (CI‐AKI) is typically defined by an increase in serum creatinine after intravascular administration of contrast medium. Because creatinine is an unreliable indicator of acute changes in kidney function, we assessed whether circulating microRNAs (miRNAs) could serve as biomarkers for early detection of CI‐AKI.Methods and ResultsUsing a rat model of CI‐AKI, we first evaluated the miRNA profile of rat plasma and kidney. Three miRNA species with >1.5‐fold increase in plasma samples of CI‐AKI rats, including miRNA‐188, miRNA‐30a, and miRNA‐30e, were selected as candidate miRNAs. Quantitative real‐time polymerase chain reaction showed that these candidate miRNAs peaked in concentration around 4 hours after contrast medium exposure and were relatively renal‐specific. We compared the plasma levels of these candidate miRNAs in 71 patients who underwent coronary angiography or percutaneous coronary intervention and developed CI‐AKI with those of 71 matched controls. The plasma levels of the 3 candidate miRNAs were significantly elevated in the CI‐AKI group as compared to the control group. Receiver operating characteristic analysis showed that these miRNAs significantly distinguished patients with CI‐AKI from those without CI‐AKI. MiRNA composites were highly accurate for CI‐AKI prediction, as shown in maximized specificity by treble‐positive miRNA composite or maximized Youden index by any‐positive miRNA composite. Moreover, the selected miRNAs changes were associated with Mehran Risk Scores.ConclusionsPlasma levels of candidate miRNAs significantly distinguished patients with CI‐AKI from those without CI‐AKI. Thus, miRNAs are potential biomarkers for early detection of CI‐AKI.

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“…Current guidelines recommend monitoring SCr post CM exposure to detect CI‐AKI 5. Clinical studies also revealed that CyC is a reliable biomarker of CI‐AKI 14.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circulating MicroRNA‐188, ‐30a, and ‐30e as Early Biomarkers for Contrast‐Induced Acute Kidney Injury

Sun

Zhang

Ding

et al. 2016

JAHA

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“…Although contrast‐induced acute kidney injury (CIAKI) is usually reversible, blood purification is required or irreversible kidney dysfunction may develop in some patients and renal survival is shortened 8. Injection of contrast medium promotes secretion of endothelin, a vasoconstrictor peptide produce by endothelial cells, by the renal parenchyma and the resulting vasoconstriction reduces renal tissue blood flow and oxygen supply 9.…”

Section: Areas Where Clinical Application Of Hydrogen Gas Is Expectedmentioning

confidence: 99%

Promising novel therapy with hydrogen gas for emergency and critical care medicine

Sano

Suzuki

Homma

et al. 2017

Acute Medicine & Surgery

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It has been reported that hydrogen gas exerts a therapeutic effect in a wide range of disease conditions, from acute illness such as ischemia–reperfusion injury, shock, and damage healing to chronic illness such as metabolic syndrome, rheumatoid arthritis, and neurodegenerative diseases. Antioxidant and anti‐inflammatory properties of hydrogen gas have been proposed, but the molecular target of hydrogen gas has not been identified. We established the Center for Molecular Hydrogen Medicine to promote non‐clinical and clinical research on the medical use of hydrogen gas through industry–university collaboration and to obtain regulatory approval of hydrogen gas and hydrogen medical devices (http://www.karc.keio.ac.jp/center/center-55.html). Studies undertaken by the Center have suggested possible therapeutic effects of hydrogen gas in relation to various aspects of emergency and critical care medicine, including acute myocardial infarction, cardiopulmonary arrest syndrome, contrast‐induced acute kidney injury, and hemorrhagic shock.

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“…Contrast agent should be used in compliance with the recommendations of the ESUR (European Society of Urogenital Radiology) [23]. The known contraindications for intravenous contrast agent application are for example contrast agent allergy, renal insufficiency, untreated hyperthyroidism, and plasmacytoma.…”

Section: Contrast-enhanced Ctmentioning

confidence: 99%

Imaging of Appendicitis in Adults

Karul

Berliner

Keller

et al. 2014

Fortschr Röntgenstr

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Three imaging modalities are available for the diagnosis of acute appendicitis: ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). Transabdominal ultrasound should be the first-line imaging test. Abdominal CT is superior to US and is required immediately in patients with atypical clinical presentation of appendicitis and suspected perforation. However, low-dose unenhanced CT is equal to standard-dose CT with intravenous contrast agents in the detection of five signs of acute appendicitis (thickened appendiceal wall more than 2?mm, cross-sectional diameter greater than 6?mm, periappendicitis, abscess, and appendicolith). MRI is necessary in pregnant women and young adults. This review illustrates the principles of state-of-the-art imaging techniques and their clinical relevance. Key Points: ??US is the basic diagnostic method in case of suspected appendicitis. ??CT is necessary in patients with atypical presentation of appendicitis. ??MRI should be the first-line imaging test in pregnant women. Citation Format: ??Karul M, Berliner C, Keller S et?al. Imaging of Appendicitis in Adults. Fortschr R?ntgenstr 2014; 186: 551???558

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Contrast induced nephropathy: updated ESUR Contrast Media Safety Committee guidelines

Cited by 776 publications

References 152 publications

Circulating MicroRNA‐188, ‐30a, and ‐30e as Early Biomarkers for Contrast‐Induced Acute Kidney Injury

Circulating MicroRNA‐188, ‐30a, and ‐30e as Early Biomarkers for Contrast‐Induced Acute Kidney Injury

Promising novel therapy with hydrogen gas for emergency and critical care medicine

Imaging of Appendicitis in Adults

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