Contrast Media in the Cardiovascular System

Higgins, C.B.

doi:10.1007/978-3-642-69515-5_4

Cited by 13 publications

(1 citation statement)

References 162 publications

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“…The intracoronary administration of contrast media results in nearly instantaneous contact of contrast media with myocardial cells, causing transient ischemia with a metabolic stimulus provoking a transient increase in coronary blood flow (17). The viscosity of the contrast media differs among iopamidol, iomeprol and iodixanol (9.1, 13.6, and 5.8 mPa.s, respectively).…”

Section: Discussionmentioning

confidence: 99%

Contrast-induced Hyperemia as an Alternative to Drug-induced Hyperemia in the Evaluation of the Fractional Flow Reserve in Coronary Lesions

et al. 2017

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Objective Measuring the fractional flow reserve (FFR) requires the induction of coronary hyperemia, usually with adenosine, adenosine triphosphate (ATP), or papaverine. However, adenosine can induce rhythmic complications, and intracoronary boluses of papaverine that prolong the QT interval can cause ventricular tachycardia. Injection of contrast media, which is routinely performed to validate the FFR guidewire placement, also induces hyperemia and may be an alternative method of measuring the FFR. We evaluated the diagnostic accuracy of the FFR after contrast hyperemia (FFRcont) compared to FFR evaluated after intracoronary papaverine (FFRpp). Methods This study included 109 lesions in 93 patients (mean age 70.4±8.7 years) with stable coronary disease. The FFR was measured as follows: 1) baseline pressure value; 2) FFRcont after intracoronary contrast injection (iopamidol, 8 mL for left coronary artery [LCA] or 6 mL for right coronary artery [RCA]); 3) FFRpp after intracoronary injection of papaverine (12 mg for LCA or 8 mg for RCA). Results FFRcont values were strongly correlated with FFRpp (R=0.940, p<0.0001; FFRpp = FFRcont ×1.007-0.032). The best cut-off point in the receiver operator curve analysis for predicting a FFRpp <0.80 was 0.82 (area under the curve =0.980; sensitivity 95.1%, specificity 91.2%, positive predictive value 86.7%, negative predictive value 96.9%). Conclusion FFRcont is highly accurate for predicting FFRpp. An FFRcont threshold value of 0.82 provides excellent sensitivity and a negative predictive value. FFRcont is an alternative method of inducing hyperemia.

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Section: Discussionmentioning

confidence: 99%

Contrast-induced Hyperemia as an Alternative to Drug-induced Hyperemia in the Evaluation of the Fractional Flow Reserve in Coronary Lesions

et al. 2017

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Radiopaques

Peng

2003

Burger's Medicinal Chemistry and Drug Discovery

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This review discusses radiopaques from research and development to application. Radiopaques attenuate X‐rays and may be either high atomic‐numbered materials or iodinated organic compounds. The latter may appear sometimes in liposomes or particulates. The theoretical and historical aspects, classification by structures, methods of synthesis, structure‐activity relationship, physical, chemical, and pharmacological properties, and related reactions, essential to the understanding of safety, tolerability, and efficacy of radiopaques in medical use, are included in the discussion.

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Sodium and Oxygen Addition to Nonionic Contrast Media. Effects on Contractile Force and Risk of Ventricular Fibrillation in the Isolated Rabbit Heart

Bååth

1991

Frontiers in European Radiology

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Contrast Media in the Cardiovascular System

Cited by 13 publications

References 162 publications

Contrast-induced Hyperemia as an Alternative to Drug-induced Hyperemia in the Evaluation of the Fractional Flow Reserve in Coronary Lesions

Contrast-induced Hyperemia as an Alternative to Drug-induced Hyperemia in the Evaluation of the Fractional Flow Reserve in Coronary Lesions

Radiopaques

Sodium and Oxygen Addition to Nonionic Contrast Media. Effects on Contractile Force and Risk of Ventricular Fibrillation in the Isolated Rabbit Heart

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