Contrast Media Increase Vascular Endothelial Permeability by Inhibiting Nitric-Oxide Production

Furuta, Wakako; Yamauchi, Atsushi; Dohgu, Shinya; Nakagawa, Sinsuke; Sendo, Toshiaki; Makino, Kazutaka; Oishi, Ryozo; Kataoka, Yasufumi

doi:10.1097/00004424-200201000-00004

Cited by 18 publications

(7 citation statements)

References 35 publications

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“…In another study, Furuta et al [34] showed that IXG and iohexol (a nonionic RC) reduced NO 2 − levels in human endothelial cell culture; this effect on NO was associated to an increased endothelial cell permeability, which was inhibited by sodium nitroprusside (SNP, an NO donor) and exacerbated by L-NMMA (N G -monomethyl-L-arginine, an NO inhibitor).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the nitric oxide production in rat renal artery smooth muscle cells culture exposed to radiocontrast agents

Ribeiro

Silva

Kurihara

et al. 2004

Kidney International

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The RC (except IDX) significantly reduced NO in rVSMC, which was more pronounced after IXT treatment (57.3%). This was not related to the reduced cell viability (15.8%) or to its high osmolality, because in MT35, with similar osmolality as IXT, NO decreased only 11.0% relatively to the control. Neither the media osmolality nor the cell viability was altered by IXG or IBT. The decreased NO could explain the vasoconstriction and, therefore, the acute renal failure by RC.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the nitric oxide production in rat renal artery smooth muscle cells culture exposed to radiocontrast agents

Ribeiro

Silva

Kurihara

et al. 2004

Kidney International

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“…Ultimately, additional factors, such as viscosity or some form of chemotoxicity, may play a role. Theories have included effects on vascular smooth muscle contractility (although there is ex vivo evidence that this is not the case (36)) and effects on vascular endothelial permeability secondary to inhibition of nitric oxide production (37).…”

Section: Osmolalitymentioning

confidence: 99%

MR contrast agents: Physical and pharmacologic basics

Lin

Brown

2007

Magnetic Resonance Imaging

225

175

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Since approval of the first magnetic resonance (MR) contrast agent was granted in 1988, there has been remarkable growth in the utilization of intravenous gadolinium (Gd)-based agents. Currently it is estimated that nearly half of all MR studies performed are contrast-enhanced. Despite containing a toxic heavy metal, these agents have proven to be not only an effective diagnostic adjunct to non-enhanced MRI, but also remarkably well tolerated and safe. As a result, conventional wisdom has been that MR contrast media are "biologically inert," a notion that is clearly false. Ultimately, it is the radiologist's responsibility to understand the potential adverse effects of Gd-based agents and the special situations in which they are likely to occur; however, the basic pharmacology of contrast agents is generally not included in medical school curricula or formally taught in residency. The purpose of this review is to discuss the mechanism of action of MR contrast agents and relevant aspects of their clinical pharmacology, including effects on the cardiovascular and renal systems, potential laboratory errors, and special situations involving women and children. We also briefly discuss the issue of nephrogenic systemic fibrosis (NSF).

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“…This decrease was significantly attenuated by L-arginine, suggesting that NO plays a major role in the pathogenesis of radiocontrast-induced acute renal failure (21). One recent study suggested that contrast media increase vascular endothelial permeability by inhibiting NO production, with consequent vascular endothelium-related adverse effects (22).…”

Section: Discussionmentioning

confidence: 99%

Ionic radiocontrast inhibits endothelium-dependent vasodilation of the canine renal artery in vitro: possible mechanism of renal failure following contrast medium infusion

Discigil¹,

Évora

Pearson

et al. 2004

Braz J Med Biol Res

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To determine if radiocontrast impairs vascular relaxation of the renal artery, segments (4-5 mm in length) of canine renal artery were suspended in vitro in organ chambers to measure isometric force (95% O 2 /5% CO 2 , at 37ºC). Arterial segments with and without endothelium were placed at the optimal point of their length-tension relation and incubated with 10 µM indomethacin to prevent synthesis of endogenous prostanoids. The presence of nonionic radiocontrast (iohexol, Omnipaque 350, 1 ml in 25 ml control solution, 4% (v/v)) did not alter endothelium-dependent relaxation to acetylcholine in rings precontracted with both norepinephrine and prostaglandin F 2α (N = 6). When the rings were precontracted with prostaglandin F 2α , the presence of ionic contrast did not inhibit the relaxation of the arteries. However, in canine renal arteries contracted with norepinephrine, the presence of ionic radiocontrast (diatrizoate meglumine and diatrizoate sodium, MD-76, 1 ml in 25 ml control solution, 4% (v/v)) inhibited relaxation in response to acetylcholine, sodium nitroprusside (N = 6 in each group), and isoproterenol (N = 5; P < 0.05). Rings were relaxed less than 50% of norepinephrine contraction. Following removal of the contrast, vascular relaxation in response to the agonists returned to normal. These results indicate that ionic radiocontrast nonspecifically inhibits vasodilation (both cAMP-mediated and cGMP-mediated) of canine renal arteries contracted with norepinephrine. This reversible impairment of vasodilation could inhibit normal renal perfusion and act as a mechanism of renal failure following radiocontrast infusion. In the adopted experimental protocol the isoproterenol-induced relaxation of renal arteries precontracted with norepinephrine was more affected, suggesting a pivotal role of the cAMP system.

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Contrast Media Increase Vascular Endothelial Permeability by Inhibiting Nitric-Oxide Production

Abstract: The present study suggested that contrast media increase vascular endothelial permeability by inhibiting NO production, leading to vascular endothelium-related adverse effects of contrast media.

Cited by 18 publications

References 35 publications

Evaluation of the nitric oxide production in rat renal artery smooth muscle cells culture exposed to radiocontrast agents

Evaluation of the nitric oxide production in rat renal artery smooth muscle cells culture exposed to radiocontrast agents

MR contrast agents: Physical and pharmacologic basics

Ionic radiocontrast inhibits endothelium-dependent vasodilation of the canine renal artery in vitro: possible mechanism of renal failure following contrast medium infusion

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