Contrast media inhibit exogenous surfactant therapy in rats with acute respiratory distress syndrome

Kesecioğlu, Jozef; Haitsma, Jack J.; Schultz, Marcus J.; Heeten, Gerard J. den; Lachmann, Burkhard

doi:10.1111/j.1475-097x.2006.00659.x

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…We used saline lavage to deplete surfactant in the rat lung. Saline lung lavage is a widely used rat model to investigate lung injury (8,20). The Pa O 2 /FI O 2 was used as a parameter to monitor the success of the lung injury.…”

Section: Discussionmentioning

confidence: 99%

Time and volume dependence of dead space in healthy and surfactant-depleted rat lungs during spontaneous breathing and mechanical ventilation

Dassow

Schwenninger

Runck

et al. 2013

Journal of Applied Physiology

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Volumetric capnography is a standard method to determine pulmonary dead space. Hereby, measured carbon dioxide (CO2) in exhaled gas volume is analyzed using the single-breath diagram for CO2. Unfortunately, most existing CO2 sensors do not work with the low tidal volumes found in small animals. Therefore, in this study, we developed a new mainstream capnograph designed for the utilization in small animals like rats. The sensor was used for determination of dead space volume in healthy and surfactant-depleted rats (n = 62) during spontaneous breathing (SB) and mechanical ventilation (MV) at three different tidal volumes: 5, 8, and 11 ml/kg. Absolute dead space and wasted ventilation (dead space volume in relation to tidal volume) were determined over a period of 1 h. Dead space increase and reversibility of the increase was investigated during MV with different tidal volumes and during SB. During SB, the dead space volume was 0.21 ± 0.14 ml and increased significantly at MV to 0.39 ± 0.03 ml at a tidal volume of 5 ml/kg and to 0.6 ± 0.08 ml at a tidal volume of 8 and 11 ml/kg. Dead space and wasted ventilation during MV increased with tidal volume. This increase was mostly reversible by switching back to SB. Surfactant depletion had no further influence on the dead space increase during MV, but impaired the reversibility of the dead space increase.

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Section: Discussionmentioning

confidence: 99%

Time and volume dependence of dead space in healthy and surfactant-depleted rat lungs during spontaneous breathing and mechanical ventilation

Dassow

Schwenninger

Runck

et al. 2013

Journal of Applied Physiology

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show abstract

Characterization of inflammation in a rat model of acute lung injury after repeated pulmonary lavage

Menk

Graw

Steinkraus

et al. 2015

Experimental Lung Research

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Contrast media inhibit exogenous surfactant therapy in rats with acute respiratory distress syndrome

Abstract: The ionic and non-ionic contrast media used in this study, cause an impairment of the physico-chemical behaviour of exogenous surfactant. Therefore, these contrast media cannot be regarded as safe in case of accidental exposure.

Cited by 2 publications

References 19 publications

Time and volume dependence of dead space in healthy and surfactant-depleted rat lungs during spontaneous breathing and mechanical ventilation

Time and volume dependence of dead space in healthy and surfactant-depleted rat lungs during spontaneous breathing and mechanical ventilation

Characterization of inflammation in a rat model of acute lung injury after repeated pulmonary lavage

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