Contrast Medium–Induced Pulmonary Vascular Hyperpermeability Is Aggravated in a Rat Climacterium Model

Tominaga, Koji; Kataoka, Yasufumi; Sendo, Toshiaki; Furuta, Wakako; Niizeki, Midori; Oishi, And Ryozo

doi:10.1097/00004424-200103000-00001

Cited by 19 publications

(6 citation statements)

References 32 publications

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“…Furthermore, oestrogen and progesterone administration attenuated emphysematous and inflammatory changes in the lung as well as improved congestion and oedema following sepsis [ 87 ]. Tominaga et al showed that oophorectomized animals displayed a 2.6-fold increase in vascular permeability following ioxaglate treatment (a contrast medium that increases vascular permeability) compared to controls and that this effect was blocked following estradiol administration [ 106 ]. These effects may be secondary to the decreased expression of keratinocyte-derived chemokines (KDC), migration inhibitory factor (MIF) and TLR-4, which in turn reduces cytokine/chemokine production and neutrophil infiltration, reducing oedema formation and subsequent organ damage [ 107 , 108 ].…”

Section: Reviewmentioning

confidence: 99%

The influence of sex steroid hormones on the response to trauma and burn injury

Al-Tarrah

Moiemen²,

Lord

2017

Burns &Amp; Trauma

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Trauma and related sequelae result in disturbance of homeostatic mechanisms frequently leading to cellular dysfunction and ultimately organ and system failure. Regardless of the type and severity of injury, gender dimorphism in outcomes following trauma have been reported, with females having lower mortality than males, suggesting that sex steroid hormones (SSH) play an important role in the response of body systems to trauma. In addition, several clinical and experimental studies have demonstrated the effects of SSH on the clinical course and outcomes following injury. Animal studies have reported the ability of SSH to modulate immune, inflammatory, metabolic and organ responses following traumatic injury. This indicates that homeostatic mechanisms, via direct and indirect pathways, can be maintained by SSH at local and systemic levels and hence result in more favourable prognosis. Here, we discuss the role and mechanisms by which SSH modulates the response of the body to injury by maintaining various processes and organ functions. Such properties of sex hormones represent potential novel therapeutic strategies and further our understanding of current therapies used following injury such as oxandrolone in burn-injured patients.

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Section: Reviewmentioning

confidence: 99%

The influence of sex steroid hormones on the response to trauma and burn injury

Al-Tarrah

Moiemen²,

Lord

2017

Burns &Amp; Trauma

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“…Experimental studies have shown that ioxaglate, which induced the largest increase in the PVR of the isolated rat lung preparation, is more cytotoxic to the vascular endothelium than diatrizoate and non-ionic contrast media (Table 1) (Benyon et al 1994;Zhang et al 2000;Emery et al 2001). Ioxaglate induced greater pulmonary edema in the rat than non-ionic monomeric contrast media (Mare et al 1984;Sendo et al 2000;Tominaga et al 2001). Interestingly, in the rat nitric oxide (Sendo et al 2000) and estrogen (Tominaga et al 2001) offered some protection against ioxaglate-induced pulmonary edema.…”

Section: Contrast Medium-induced Pulmonary Edemamentioning

confidence: 99%

“…Ioxaglate induced greater pulmonary edema in the rat than non-ionic monomeric contrast media (Mare et al 1984;Sendo et al 2000;Tominaga et al 2001). Interestingly, in the rat nitric oxide (Sendo et al 2000) and estrogen (Tominaga et al 2001) offered some protection against ioxaglate-induced pulmonary edema.…”

Section: Contrast Medium-induced Pulmonary Edemamentioning

confidence: 99%

Pulmonary Effects of Iodine-Based Contrast Media

Morcos

2014

Medical Radiology

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“…At the seventh day after ovariectomy, rats were treated intramuscularly with either 17β-estradiol (1 mg/kg) or vehicle (sesame oil) once a week for three weeks, as described previously. 23 Measurement of extravasation of plasma protein in rat lungs. Plasma extravasation in lungs was evaluated, as described previously.…”

Section: Animals Male and Femalementioning

confidence: 99%

Ovariectomy aggravates hypersensitivity reactions to paclitaxel in rats

Goromaru¹,

Itoh²,

Sendo³

et al. 2005

Cancer Biology & Therapy

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The incidence of hypersensitivity reactions is still a matter of serious concern during chemotherapy with paclitaxel, particularly in patients with ovarian cancer. We recently reported that intravenous injection of paclitaxel causes acute lung injury characterized by vascular hyperpermeability, edema and respiratory dysfunction in rats. In the present study, we investigated the influence of ovariectomy on the paclitaxel-induced acute lung injury in rats. Ovariectomy worsened paclitaxel-induced acute lung injury, which was reversed by 17beta-estradiol. The mRNA expression for endothelial nitric oxide synthase was reduced in lungs of ovariectomized rats. To determine the role for nitric oxide, we examined the effects of several agents that modulate nitric oxide concentration on the pulmonary response to paclitaxel. In ovary-intact rats, a nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester exaggerated paclitaxel-induced acute lung injury, while nitric oxide donors such as sodium nitroprusside and isosorbide dinitrate attenuated the lung injury. Sodium nitroprusside was also effective in alleviating the paclitaxel-induced acute lung injury in ovariectomized rats. These findings suggest that ovariectomy enhances the susceptibility to paclitaxel hypersensitivity, in which decrease in estrogen and subsequent reduction in nitric oxide synthesis may be involved.

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Contrast Medium–Induced Pulmonary Vascular Hyperpermeability Is Aggravated in a Rat Climacterium Model

Abstract: These findings suggest that climacterium is included, at least in part, in the risk factors for contrast-induced adverse pulmonary reactions, and this risk is lowered by estrogen replacement therapy.

Cited by 19 publications

References 32 publications

The influence of sex steroid hormones on the response to trauma and burn injury

The influence of sex steroid hormones on the response to trauma and burn injury

Pulmonary Effects of Iodine-Based Contrast Media

Ovariectomy aggravates hypersensitivity reactions to paclitaxel in rats

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