Contrast Nephropathy: Isosmolar and Low-Osmolar Contrast Media

Detrenis, Simona; Meschi, Michele; Savazzi, G

doi:10.1016/j.jacc.2006.12.002

Cited by 7 publications

(9 citation statements)

References 10 publications

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“…However, this analysis included trials that were not specifically designed to study the incidence of CI-AKI and in which renal function was not systematically determined in all patients. Thus, this study was limited by ascertainment bias (17).…”

mentioning

confidence: 99%

The Relative Renal Safety of Iodixanol Compared With Low-Osmolar Contrast Media

Reed

Meier

Tamhane

et al. 2009

JACC: Cardiovascular Interventions

197

136

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mentioning

confidence: 99%

The Relative Renal Safety of Iodixanol Compared With Low-Osmolar Contrast Media

Reed

Meier

Tamhane

et al. 2009

JACC: Cardiovascular Interventions

197

136

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“…One publication cited that the creatinine levels peaked at 96 hours post contrast administration and thus CIN may be overlooked or underestimated in studies measuring creatinine concentrations at 48 hours or less [19]. Fortunately, CIN is usually self limiting with serum creatinine levels returning to near baseline values within 1–3 weeks [17]. Creatinine levels, although most commonly used, are not the ideal method of evaluating CIN as renal function must be severely compromised before elevation occurs [13].…”

Section: Introductionmentioning

confidence: 99%

“…Creatinine levels, although most commonly used, are not the ideal method of evaluating CIN as renal function must be severely compromised before elevation occurs [13]. Various risk factors for CIN, such as pre-existing renal impairment, dehydration, diabetes mellitus (independently or with associated renal disease) and advanced congestive heart failure have been identified [8,10,16,17,20,21] and thus, contrast agents may be contributory rather than causative in CIN. Co-morbidities such as hypertension, anaemia and peripheral vascular disease may also play a role [20].…”

Section: Introductionmentioning

confidence: 99%

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The effects of repeated intravenous iohexol administration on renal function in healthy beagles – a preliminary report

et al. 2012

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BackgroundContrast induced nephrotoxicity (CIN) is a well described syndrome in humans undergoing contrast medium examinations. To date CIN has received minimal attention in the veterinary literature despite increasing use of contrast medium examinations in computed tomographic studies.MethodsThis prospective study evaluated the effect of 1290 mg/kg iohexol given intravenously to 5 normal beagle dogs in a divided dose at an interval of 6–8 weeks. Renal function was evaluated by means of scintigraphically determined glomerular filtration rate (GFR) and a variety of laboratory assays.ResultsOnly GFR showed a significant decrease (17%) after the second injection but not to a clinically or pathologically significant level.ConclusionsNo clinically significant effect of repeated contrast medium administration was determined in this limited study. However in dogs with reduced renal function the risk of CIN is likely to increase dramatically post contrast administration.

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“…The disparate results of these previous 14 clinical trials led to a proliferation of systematic reviews and meta-analyses comparing the nephrotoxicity of IOCM iodixanol and various LOCM; five of which have now been published [32,[62][63][64][65][66] . Among earlier meta-analyses by McCullough et al [62] , pooled data from 2727 patients from 16 doubleblind, RCTs have indicated that use of the IOCM iodixanol is associated with smaller rises in creatinine and lower rates of RCIN than LOCM (1.4% vs 3.5%, P < 0.001), especially in patients with CKD or CKD and diabetes mellitus.…”

Section: Type Of Contrast Agentsmentioning

confidence: 99%

Preventing radiocontrast-induced nephropathy in chronic kidney disease patients undergoing coronary angiography

Hung¹,

Lin²,

Hung³

et al. 2012

WJC

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Radiocontrast-induced nephropathy (RCIN) is an acute and severe complication after coronary angiography, particularly for patients with pre-existing chronic kidney disease (CKD). It has been associated with both short-and long-term adverse outcomes, including the need for renal replacement therapy, increased length of hospital stay, major cardiac adverse events, and mortality. RCIN is generally defined as an increase in serum creatinine concentration of 0.5 mg/dL or 25% above baseline within 48 h after contrast administration. There is no effective therapy once injury has occurred, therefore, prevention is the cornerstone for all patients at risk for acute kidney injury (AKI). There is a small but growing body of evidence that prevention of AKI is associated with a reduction in later adverse outcomes. The optimal strategy for preventing RCIN has not yet been established. This review discusses the principal risk factors for RCIN, evaluates and summarizes the evidence for RCIN prophylaxis, and proposes recommendations for preventing RCIN in CKD patients undergoing coronary angiography.

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Contrast Nephropathy: Isosmolar and Low-Osmolar Contrast Media

Cited by 7 publications

References 10 publications

The Relative Renal Safety of Iodixanol Compared With Low-Osmolar Contrast Media

The Relative Renal Safety of Iodixanol Compared With Low-Osmolar Contrast Media

The effects of repeated intravenous iohexol administration on renal function in healthy beagles – a preliminary report

Preventing radiocontrast-induced nephropathy in chronic kidney disease patients undergoing coronary angiography

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