Contrast Sensitivity and Stereoacuity in Successfully Treated Refractive Amblyopia

Jia, Yu; Ye, Qingqing; Zhang, Shenglan; Feng, Lei; Liu, Jing; Xu, Zixuan; Zhuang, Yijing; He, Yunsi; Zhou, Yusong; Chen, Xiaolan; Yao, Ying Xue; Jiang, Rengang; Thompson, Benjamin; Li, Jinrong

doi:10.1167/iovs.63.1.6

Cited by 22 publications

(41 citation statements)

References 49 publications

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“…Nil stereopsis was recorded as 5,000 arc sec ( 25 ). Full details of the standardized testing protocol have been reported previously ( 19 ).…”

Section: Methodsmentioning

confidence: 99%

“…Improvement from the first hospital visit to the point at which the criteria for successful treatment were met was also calculated for the visual acuity measure. Monocular contrast sensitivities were converted to a single area under the log contrast sensitivity function (AULCSF) value ( 19 ). Monocular visual acuity and AULCSF values were entered into the model separately, as an interocular difference (amblyopic eye−fellow eye) and as an absolute interocular difference.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we took advantage of criteria for defining amblyopia treatment success used by the Pediatric Eye Disease and Investigator Group (PEDIG) and a unique database of amblyopia treatment records ( 19 ) to retrospectively investigate risk factors for amblyopia regression in patients with successfully treated anisometropic amblyopia. To determine amblyopia treatment success, we combined criteria used across different PEDIG amblyopia treatment studies.…”

Section: Introductionmentioning

confidence: 99%

“…We considered amblyopia treatment to be successful if any of the following three criteria were met at 3–12 months follow-up: interocular difference (IOD) in acuity <0.2 logMAR (referred to as the IOD criterion) ( 4 ), best corrected visual acuity (BCVA) improvement of 3 or more logMAR lines (the BCVA improvement criterion) ( 20 , 21 ) or, amblyopic eye visual acuity ≤ 0.1 logMAR (the BCVA achievement criterion) ( 20 , 21 ). We applied the PEDIG amblyopia treatment success criteria to records of patients with anisometropic amblyopia within the Uniting Functions in Ophthalmology and Optometry (UFOs) Database ( 19 ) that is held at Zhongshan Ophthalmic Center, a major regional eye hospital in Guangzhou, China. The database contains longitudinal clinical and visual function data for every amblyopia patient seen at the hospital.…”

Section: Introductionmentioning

confidence: 99%

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Factors predicting regression of visual acuity following successful treatment of anisometropic amblyopia

Jia

Liu

et al. 2022

Front. Med.

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ObjectiveTo identify factors associated with visual acuity regression following successful treatment of anisometropic amblyopia.Design and methodThis was a retrospective cohort study. Database records for 100 and 61 children with anisometropic amblyopia who met at least one criterion for successful treatment proposed by the Pediatric Eye Disease Investigator Group (PEDIG) and had at least 1 year of follow-up data available after the criterion was met were analyzed. The study sample was split into two groups, those who regressed within 1 year of successful treatment (no longer met any of the PEDIG criteria for successful treatment) and those who did not. A two-step analysis involving a least absolute shrinkage and selection operator (LASSO) regression and a logistic regression were used to identify predictor variables for increased risk of regression. A broad range of clinical, perceptual, and demographic variables were included in the analyses.ResultsSixty-eight (42.5%) children regressed within 1 year of successful treatment. Among the 27 predictor variables considered within the statistical modeling process, the three most important for predicting treatment regression were the extent of amblyopic eye visual acuity improvement, age at first hospital visit and sex. Specifically, lower risk of regression was associated with larger amblyopic eye visual acuity improvement with treatment, younger age at initiation of treatment and female sex.ConclusionPatients who received treatment at a younger age and responded well to treatment had a lower risk of treatment regression. This pattern of results suggests that early detection of amblyopia and strategies that enhance treatment adherence may reduce the risk of treatment regression. The higher risk of regression in boys than girls that we observed may reflect known sex differences in brain development and /or sex differences in environment within our sample of children from South China.

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“…Nil stereopsis was recorded as 5,000 arc sec ( 25 ). Full details of the standardized testing protocol have been reported previously ( 19 ).…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Factors predicting regression of visual acuity following successful treatment of anisometropic amblyopia

Jia

Liu

et al. 2022

Front. Med.

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“…First, as ocular component growth declines with age, due to structural limitations, a slight potential for emmetropization could remain. Second, the literature suggests that the successfully treated amblyopes can still have deficits in contrast sensitivity, stereoacuity ( 41 ) and binocular balance even if the subjects reach normal visual acuity ( 42 ). These studies collectively indicate that the pathway connection between the retina and the visual cortex (dorsal and ventral stream), along with visual feedback mechanism of retinal images, is not fully established.…”

Section: Discussionmentioning

confidence: 99%

Refraction development in anisometropic amblyopia with patching therapy

Chen

Zuo²,

Xiong³

et al. 2022

Front. Med.

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PurposeTo investigate the development of refraction in anisometropic amblyopia who had been with patching therapy.MethodsWe retrospectively reviewed 37,528 medical records of the amblyopes who had been treated with patching therapy between July 2003 and January 2020 at the School of Optometry and Ophthalmology and Eye Hospital of Wenzhou Medical University. We included unilateral anisometropic amblyopia with a follow-up length of not < 2 years. In total, 371 cases were enrolled and followed up for a mean of 4.76 ± 2.11 years. The subjects were then divided into different groups and periods according to their initial spherical equivalent (SE) refractive error and best-corrected visual acuity (BCVA) of the amblyopic eye. Linear mixed-effects models were fitted to calculate the annual change of SE.ResultsThe annual changes in SE were −0.32 (−0.35 to −0.30) and −0.16 (−0.19 to −0.14) D/yr for the amblyopic eye and the fellow eye, respectively. The annual changes in SE of amblyopic eyes during the treatment period and the successfully treated period were −0.36 (−0.43 to −0.29; 95% CI) and −0.27 (−0.32 to −0.23; 95% CI) D/yr, respectively; the annual SE changes of the fellow eye during the treatment period and the successfully-treated period were −0.07 (−0.14 to −0.01; 95% CI) and −0.18 (−0.22 to −0.14; 95% CI) D/yr, respectively.ConclusionThe amblyopic eye experienced a significantly greater degree of refractive error changes than the fellow eye and underwent a continuous refractive error reduction before and after 7 years old. After the patching therapy was terminated, emmetropization in the amblyopic eye remained synchronized, whereas the refractive error change was increased in the fellow eye.

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Associations between the cause of amblyopia and pre-treatment contrast sensitivity, stereoacuity, fixation, and nystagmus

Jia,

Ye,

Liu

et al. 2024

Heliyon

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Contrast Sensitivity and Stereoacuity in Successfully Treated Refractive Amblyopia

Cited by 22 publications

References 49 publications

Factors predicting regression of visual acuity following successful treatment of anisometropic amblyopia

Factors predicting regression of visual acuity following successful treatment of anisometropic amblyopia

Refraction development in anisometropic amblyopia with patching therapy

Associations between the cause of amblyopia and pre-treatment contrast sensitivity, stereoacuity, fixation, and nystagmus

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