Contrast ultrasound versus ultrasound elastography for diagnosis of breast lumps

Zhao, Wei; Yan, Kaituo; Liu, Yingying; Zhang, Zaibin

doi:10.1097/md.0000000000016132

Cited by 5 publications

(6 citation statements)

References 26 publications

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“…In this study, for the detection of benign breast tumors (BI-RADS score, 2), breast ultrasound had a significantly higher detection rate than mammography. Ultrasound has previously been shown to have high specificity for the detection of malignant and benign lesions of the breast [ 15 ]. In premenopausal Chinese women, increased glandular breast tissue affects the mammographic findings [ 8 ], and mammography has a higher risk of overdiagnosis [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

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A Cross-Sectional Observational Study to Compare the Role of Ultrasound with Mammography in Women Identified at High Risk for Breast Cancer in a Population in China

Zhong

Rong

et al. 2020

Med Sci Monit

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Background Currently, there is no national breast cancer screening program in China. In countries that have screening programs, screening mammography is used. This study aimed to compare the imaging parameters and diagnostic findings between ultrasound and mammography in women at high risk who had a histologically confirmed diagnosis of breast cancer in a population in China. Material/Methods A cross-sectional observational study included 1,687 women with a risk score of ≥30, according to the cancer risk assessment model, who underwent breast ultrasound and mammography. Women who had a Breast Imaging-Reporting and Data System (BI-RADS) score of 4 or 5 were identified, and 155 women had breast cancer confirmed by breast biopsy and histology. The ultrasound and mammography findings were evaluated and compared. Results Breast ultrasound resulted in significantly fewer inconclusive results (BI-RADS score, 0), when compared with mammography (p=0.046). In cases with a histologically confirmed diagnosis of breast cancer (BI-RADS score, 4), the diagnostic sensitivity of breast ultrasound and mammography were 0.989 and 0.859, respectively. In cases with a histologically confirmed diagnosis of breast cancer (BI-RADS score, 5), the diagnostic sensitivity of breast ultrasound and mammography were 1.000 and 0.984, respectively. In cases with a histologically confirmed diagnosis of benign breast lesions (BI-RADS score, 2), there was no significant difference between breast ultrasound and mammography. Conclusions In a population of women in China, breast ultrasound was a more sensitive diagnostic imaging method for women with high risk BI-RADS 4 and 5 breast lesions.

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Section: Discussionmentioning

confidence: 99%

“…The beneficial score for each diagnostic modality was evaluated according to Equation 1 of the BI-RADS level of evidence [ 15 ]:…”

Section: Methodsmentioning

confidence: 99%

A Cross-Sectional Observational Study to Compare the Role of Ultrasound with Mammography in Women Identified at High Risk for Breast Cancer in a Population in China

Zhong

Rong

et al. 2020

Med Sci Monit

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“…Similar results were reported in the current study. When a cutoff value of 3 was utilized for the elasticity score, Sinha R et al discovered a susceptibility of 97.0% and an accuracy of 86.7% in their study of 120 patients with breast lumps [16][17][18]. When a strain ratio (S.R.)…”

Section: Resultsmentioning

confidence: 99%

Comparative analysis of mammary lump histology and elasto-graphy results at a tertiary hospital

Sune,

Ambad,

Jha

et al. 2024

E3S Web Conf.

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In the majority of India's metropolitan populations, mammary carcinoma has become the commonest type of carcinoma. A non-invasive imaging method called mammary sono-elasto-graphy can reveal information about mammary lesions. Aims & objectives: In the current research, we examined the diagnostic efficacy of elasto-graphy and histopathological findings of mammary lumps. Material and Methods: The current investigation involved Female patients had solid mammary lesions less than 3 cm in size that were visible on sonography. Classified as BI RADS 3 and 4 lesions, these lesions. Results: 252 female patients had U.S.G. elastography, followed by biopsy or surgery, and histopathology reports were available during the research period. Histopathologically, 104 (41.72%) samples were benign, and the remaining 148 (58.73%) were malignant. Age, B.I.R.A.D.S., Elastography Score, and Strain Ratio were all statistically higher in malignant cases than in benign patients (p 0.001). According to Histo-pathological analysis, fibroadenoma (77.03%) accounted for the majority of benign lesions, followed by Abscess (5.41%), sclerosing adenosis (1.35%), benign fibroepithelial lesion (6.76%), and fibrocystic disease (9.46%). Conversely, poorly differentiated invasive carcinoma (5.77%), invasive ductal carcinoma (67.31%), and invasive mucinous carcinoma (13.46%), IL.C. (5.77%), medullary carcinoma (1.92%), papillary carcinoma (1.92%), and phylloid (1.92%) made up the bulk of malignant cases, Excellent results were noticed with the combination of Ultrasound Score + Elastography Score + Strain Ratio, with scores of 96.00%, 96.05%, 96.03%, 94.12%, and 97.33%, respectively, for susceptibility, accuracy, diagnostic accuracy, and N.P.V. and PPV. Conclusion: The ability to distinguish between benign and malignant mammary masses using ultra-sound elasto-graphy, strain elasto-graphy, and ultra-sound score has good susceptibility, accuracy, and diagnostic accuracy.

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“…Ultimately, 27 studies were included for analysis. 10 , 15 - 40 The complete literature screening and selection process is presented in Figure 2 .…”

Section: Resultsmentioning

confidence: 99%

Diagnostic Value of Contrast-Enhanced Ultrasonography With SonoVue in the Differentiation of Benign and Malignant Breast Lesions: A Meta-Analysis

Zhou

Jin

et al. 2020

Technol Cancer Res Treat

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Purpose: A meta-analysis was conducted to evaluate the diagnostic performance of contrast-enhanced ultrasonography using the contrast agent SonoVue to differentiate benign from malignant breast lesions. Method: A comprehensive search of the literature was performed using the Embase, PubMed, and Web of Science databases to retrieve studies published before February 2020. Data were extracted, and pooled sensitivity, specificity, and diagnostic odds ratios were calculated with meta-analysis software. Heterogeneity was evaluated via the Q test and I2 statistic. Meta-regression and subgroup analyses were applied to evaluate potential sources of heterogeneity. Publication bias was assessed using the Deeks’ funnel plot asymmetry test. A summary receiver operating characteristic curve (SROC) was constructed. Results: A total of 27 studies including 5378 breast lesions subjected to CEUS examination with SonoVue were included in the meta-analysis. The pooled sensitivity and specificity values were 0.90 (95% confidence interval [CI], 0.88–0.91; inconsistency index [ I2] = 75.7%) and 0.83 (95% CI, 0.82–0.85; I2 = 91.0%), respectively. The pooled diagnostic odds ratio was 48.35% (95% CI, 31.22–74.89; I2 = 77.6%). The area under the summary receiver operating characteristic curve (AUC) was 0.9354. Meta-regression analysis revealed the region of patient residence and dose of contrast agent as potential sources of heterogeneity (P < .01). Subgroup analysis showed a higher area under the summary receiver operating characteristic curve for European and higher contrast agent dose subgroups (P < .05). Conclusion: Contrast-enhanced ultrasonography with SonoVue displays high sensitivity, specificity, and accuracy when differentiating benign from malignant breast lesions. Despite its current limitations, this technique presents a promising tool for diagnosing breast lesions in clinical practice.

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Contrast ultrasound versus ultrasound elastography for diagnosis of breast lumps

Cited by 5 publications

References 26 publications

A Cross-Sectional Observational Study to Compare the Role of Ultrasound with Mammography in Women Identified at High Risk for Breast Cancer in a Population in China

A Cross-Sectional Observational Study to Compare the Role of Ultrasound with Mammography in Women Identified at High Risk for Breast Cancer in a Population in China

Comparative analysis of mammary lump histology and elasto-graphy results at a tertiary hospital

Diagnostic Value of Contrast-Enhanced Ultrasonography With SonoVue in the Differentiation of Benign and Malignant Breast Lesions: A Meta-Analysis

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