Contrast Ventriculography:Wall Motion Disorder Without Angina Pectoris During Exercise-Induced Ischemia

Gleichmann, U.; Fassbender, D; Mannebach, Hermann; Vogt, J; Trieb, G

doi:10.1007/978-3-642-69589-6_12

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…They found no difference in coronary anatomy between the two groups. Gleichman et al [23] performed exercise radionuclide ventri culography in 141 patients and found no difference between patients with or without angina on exercise. However, on coronary angiography among a subset of 46 patients with exercise-induced wall motion abnormali ties in the absence of prior infarction, one-vessel disease was present in 55% of asymptomatic patients, and threevessel disease was present in only 15 % compared to 19 and 38, respectively, in those with exercise-induced angi na.…”

Section: Discussionmentioning

confidence: 99%

Functional and Anatomic Correlates of Asymptomatic and Symptomatic Stress Responses in Patients Free from Prior Infarction

Sharma¹,

Teague²,

Corn³

et al. 1990

Am J Noninvas Cardiol

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In order to elucidate the anatomic and functional correlates of asymptomatic stress responses in patients with coronary artery disease (CAD) free from prior infarction but with chronic chest discomfort despite medical therapy, we recorded electrocardiographic, radionuclide, and Doppler responses during upright treadmill testing and supine bicycle exercise in 16 patients with normal coronary anatomy and in 68 patients with greater than 50% diameter reduction in one or more coronary arteries. Thirty-one CAD patients stopped for angina (symptomatic group), while 37 stopped for fatigue during stress testing (asymptomatic group). The asymptomatic group developed less ST segment depression (0.9 ± 0.8 mm) than the symptomatic group (1.3 ± 0.8 mm), but more than the normal group (0.4 ± 0.4 mm; p < 0.05). At peak treadmill exercise, the maximal Doppler acceleration in the normal group (38 ± 13 m/s/s) was higher than both in the asymptomatic group (28 ± 13 m/s/s; p < 0.05) and in the symptomatic group (24 ± 8 m/s/s; p < 0.001). During peak supine exercise, the augmentation of radionuclide ejection fraction in the normal group (+9 ± 7%) was higher than both in the asymptomatic group (+1 ± 10%; p < 0.01) and in the symptomatic group (–3 ± 8%; p < 0.001). At coronary angiography, the asymptomatic group had commonly single-vessel disease (63%), while symptomatic patients had multivessel disease (74%). We conclude that asymptomatic stress responses in CAD patients free from prior myocardial infarction correlate with less extensive coronary artery disease and higher capacity to augment ventricular function during exercise.

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Section: Discussionmentioning

confidence: 99%